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BGC0002344NRPS

A50926 A;A50926 B

Producing organism
Nonomuraea coxensis DSM 45129
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Streptosporangiales›Streptosporangiaceae›Nonomuraea
Biosynthetic class
NRPS (Type 1)
Total steps
11
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map36 genes · 69,065 bp

AmTAAAAAAA10 kb69.1 kb visible · 69,065 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
CnCOM N-term
TEThioesterase (TE)
EEpimerization (E)
ECHEnoyl-CoA hydratase
AmTAminotransferase I/II
XPutative domain (X)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

11 steps · 11 edges
Step 1M1
Nocox_13350
+4-hydroxyphenylgl…
Step 9
Start
+mannose
Step 2M2
Nocox_13350
+Tyrosine
Step 3M3
Nocox_13355
+3,5-dihydroxyphen…
Step 4M4
Nocox_13360
+4-hydroxyphenylgl…
Step 5M5
Nocox_13360
+4-hydroxyphenylgl…
Step 6M6
Nocox_13360,Nocox_13305
+Tyrosine
Step 7M7
Nocox_13365
+3,5-dihydroxyphen…
Step 8TE
Nocox_13365,Nocox_13375…
Step 10
Nocox_13310,Nocox_13325…
+terminal amine
Step 11
Nocox_13310,Nocox_13325…
+terminal amine
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12344-1Nocox_13350M1
4-hydroxyphenylglycine
OC(C(C1=CC=C(O)C=C1)N)=O—
22344-2Nocox_13350M2
2344-1;Tyrosine
from: 2344-1
OC(C(CC1=CC=C(O)C=C1)NC(C(C2=CC=C(O)C=C2)N)=O)=O—
32344-3Nocox_13355M3
2344-2;3,5-dihydroxyphenylglycine
from: 2344-2
OC(C(C1=CC(O)=CC(O)=C1)NC(C(CC2=CC=C(O)C=C2)NC(C(C3=CC=C(O)C=C3)N)=O)=O)=O—
42344-4Nocox_13360M4
2344-3;4-hydroxyphenylglycine
from: 2344-3
OC(C(C1=CC=C(O)C=C1)NC(C(C2=CC(O)=CC(O)=C2)NC(C(CC3=CC=C(O)C=C3)NC(C(C4=CC=C(O)C=C4)N)=O)=O)=O)=O—
52344-5Nocox_13360M5
2344-4;4-hydroxyphenylglycine
from: 2344-4
OC(C(NC(C(C1=CC=C(O)C=C1)NC(C(C2=CC(O)=CC(O)=C2)NC(C(CC3=CC=C(O)C=C3)NC(C(C4=CC=C(O)C=C4)N)=O)=O)=O)=O)C5=CC=C(O)C=C5)=O—
62344-6Nocox_13360,Nocox_13305M6
2344-5;Tyrosine
from: 2344-5
OC(C(NC(C(NC(C(C1=CC=C(O)C=C1)NC(C(C2=CC(O)=CC(O)=C2)NC(C(CC3=CC=C(O)C=C3)NC(C(C4=CC=C(O)C=C4)N)=O)=O)=O)=O)C5=CC=C(O)C=C5)=O)C(C6=CC=C(O)C=C6)O)=O—
72344-7Nocox_13365M7
2344-6;3,5-dihydroxyphenylglycine
from: 2344-6
OC(C(NC(C(NC(C(NC(C(C1=CC=C(O)C=C1)NC(C(C2=CC(O)=CC(O)=C2)NC(C(CC3=CC=C(O)C=C3)NC(C(C4=CC=C(O)C=C4)N)=O)=O)=O)=O)C5=CC=C(O)C=C5)=O)C(C6=CC=C(O)C=C6)O)=O)C7=CC(O)=CC(O)=C7)=O—
82344-8Nocox_13365,Nocox_13375,Nocox_13380,Nocox_13385,Nocox_13390,Nocox_13395TE
2344-7
from: 2344-7
O=C([C@@H](C1=CC2=C(O)C3=C1)NC[C@@H](NC([C@@H](CC4=CC=C(O2)C=C4)NC([C@H](N)C5=CC6=C(O)C=C5)=O)=O)C7=C(Cl)C(O)=CC(O6)=C7)N[C@@H](C(N[C@@H]([C@@H](C8=CC=C(O3)C(Cl)=C8)O)C(N[C@@H](C(O)=O)C9=CC(O)=CC(O)=C9%10)=O)=O)C%11=CC=C(O)C%10=C%11—
92344-9Start—
mannose
O[C@@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1—
102344(1)Nocox_13310,Nocox_13325,Nocox_13330,Nocox_13340,Nocox_13400,Nocox_13405—
2344-8;2344-9;2344-9;terminal amine
from: 2344-8, 2344-9, 2344-9
O=C([C@@H](C1=CC2=C(OC3=[O+][C@@H](CO)[C@H](O)C(O)[C@@H]3NC(CCCCCCCCCC)=O)C4=C1)NC[C@@H](NC([C@@H](CC5=CC=C(O2)C=C5)NC([C@H](NC)C6=CC7=C(O)C=C6)=O)=O)C8=C(Cl)C(O)=CC(O7)=C8)N[C@@H](C(N[C@@H]([C@@H](C9=CC=C(O4)C(Cl)=C9)O)C(N[C@@H](C(O)=O)C%10=CC(O)=CC(O[C@@H]%11[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O%11)=C%10%12)=O)=O)C%13=CC=C(O)C%12=C%13—
112344(2)Nocox_13310,Nocox_13325,Nocox_13330,Nocox_13340,Nocox_13400,Nocox_13405—
2344-8;2344-9;2344-9;terminal amine
from: 2344-8, 2344-9, 2344-9
O=C([C@@H](C1=CC2=C(OC3=[O+][C@@H](CO)[C@H](O)C(O)[C@@H]3NC(CCCCCCCCCCC)=O)C4=C1)NC[C@@H](NC([C@@H](CC5=CC=C(O2)C=C5)NC([C@H](NC)C6=CC7=C(O)C=C6)=O)=O)C8=C(Cl)C(O)=CC(O7)=C8)N[C@@H](C(N[C@@H]([C@@H](C9=CC=C(O4)C(Cl)=C9)O)C(N[C@@H](C(O)=O)C%10=CC(O)=CC(O[C@@H]%11[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O%11)=C%10%12)=O)=O)C%13=CC=C(O)C%12=C%13—
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