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BGC0002333PKS

lucensomycin

Producing organism
Streptomyces cyanogenus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
21
DOI
MIBiG entry
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lucensomycin

Gene Cluster Map19 genes · 87,506 bp

KSKSKSKSKSKSKSKSKSKSKSKSKSKS20 kb87.5 kb visible · 87,506 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

21 steps · 20 edges
Step 1Load
lcmA
+methylmalonyl-CoA
Step 17
lcm2
+GDP-D-mannose
Step 2M1
lcmA
+malonyl-CoA
Step 18
Step 3M2
lcmB
+malonyl-CoA
Step 19
lcm5
Step 4M3
lcmB
+malonyl-CoA
Step 5M4
lcmB
+malonyl-CoA
Step 6M5
lcmB
+malonyl-CoA
Step 7M6
lcmC
+malonyl-CoA
Step 8M7
lcmC
+malonyl-CoA
Step 9M8
lcmC
+malonyl-CoA
Step 10M9
lcmC
+malonyl-CoA
Step 11M10
lcmC
+malonyl-CoA
Inactive: KR
Step 12M11
lcmC
+malonyl-CoA
Step 13M12
lcmD
+malonyl-CoA
Step 14M13
lcmE
+malonyl-CoA
Step 15TE
lcmE,lcm3
Step 16
lcm6
Step 20
lcm4
Step 21
lcm10
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions21 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12333-1lcmALoading
methylmalonyl-CoA
OC(CC)=O—
22333-2lcmAM1
2333-1;malonyl-CoA
from: 2333-1
OC(CCCC)=O—
32333-3lcmBM2
2333-2;malonyl-CoA
from: 2333-2
OC(CC(O)CCCC)=O—
42333-4lcmBM3
2333-3;malonyl-CoA
from: 2333-3
OC(/C=C/CC(O)CCCC)=O—
52333-5lcmBM4
2333-4;malonyl-CoA
from: 2333-4
OC(/C=C/C=C/CC(O)CCCC)=O—
62333-6lcmBM5
2333-5;malonyl-CoA
from: 2333-5
OC(/C=C/C=C/C=C/CC(O)CCCC)=O—
72333-7lcmCM6
2333-6;malonyl-CoA
from: 2333-6
OC(/C=C/C=C/C=C/C=C/CC(O)CCCC)=O—
82333-8lcmCM7
2333-7;malonyl-CoA
from: 2333-7
OC(CC(/C=C/C=C/C=C/C=C/CC(O)CCCC)O)=O—
92333-9lcmCM8
2333-8;malonyl-CoA
from: 2333-8
OC(C(C)C(O)CC(/C=C/C=C/C=C/C=C/CC(O)CCCC)O)=O—
102333-10lcmCM9
2333-9;malonyl-CoA
from: 2333-9
OC(CC(O)C(C)C(O)CC(/C=C/C=C/C=C/C=C/CC(O)CCCC)O)=O—
112333-11lcmCM10
2333-10;malonyl-CoA
from: 2333-10
OC(CC(CC(O)C(C)C(O)CC(/C=C/C=C/C=C/C=C/CC(O)CCCC)O)=O)=O{'Inactive':['KR']}
122333-12lcmCM11
2333-11;malonyl-CoA
from: 2333-11
OC(CC(O)CC(CC(O)C(C)C(O)CC(/C=C/C=C/C=C/C=C/CC(O)CCCC)O)=O)=O—
132333-13lcmDM12
2333-12;malonyl-CoA
from: 2333-12
OC(/C=C/CC(O)CC(CC(O)C(C)C(O)CC(/C=C/C=C/C=C/C=C/CC(O)CCCC)O)=O)=O—
142333-14lcmEM13
2333-13;malonyl-CoA
from: 2333-13
O=C(O)/C=C/C=C/CC(O)CC(CC(O)C(C)C(O)CC(/C=C/C=C/C=C/C=C/CC(O)CCCC)O)=O—
152333-15lcmE,lcm3TE
2333-14
from: 2333-14
OC(C/C=C/C=C/C(OC(CCCC)C/C=C/C=C/C=C/C=C/C(O)C1)=O)CC2(O)OC1C(C)C(O)C2—
162333-16lcm6—
2333-15
from: 2333-15
OC(C/C=C/C=C/C(OC(CCCC)C/C=C/C=C/C=C/C=C/C(O)C1)=O)CC2(O)OC1C(C(O)=O)C(O)C2—
172333-17lcm2—
GDP-D-mannose
O=C1[C@H](O)[C@H](O)[C@@H](O[R])O[C@@H]1C—
182333-18—
2333-17
from: 2333-17
C[C@H]1O[C@H](O[R])[C@@H](O)C([C@@H]1O)=O—
192333-19lcm5—
2333-18
from: 2333-18
C[C@H]1O[C@H](O[R])[C@@H](O)[C@H](N)[C@@H]1O—
202333-20lcm4—
2333-16;2333-19
from: 2333-16, 2333-19
OC(C/C=C/C=C/C(OC(CCCC)C/C=C/C=C/C=C/C=C/C(O[C@H]1[C@@H](O)[C@H](N)[C@H](O)[C@@H](C)O1)C2)=O)CC3(O)OC2C(C(O)=O)C(O)C3—
212333lcm10—
2333-20
from: 2333-20
OC(CC(O1)C1/C=C/C(OC(CCCC)C/C=C/C=C/C=C/C=C/C(O[C@H]2[C@@H](O)[C@H](N)[C@H](O)[C@@H](C)O2)C3)=O)CC4(O)OC3C(C(O)=O)C(O)C4—
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