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BGC0002314NRPS

corbomycin

Producing organism
Streptomyces sp. WAC 01529
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type 1)
Total steps
11
DOI
MIBiG entry
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corbomycin

Gene Cluster Map27 genes · 67,305 bp

AmTCAAAEACAAAAAA10 kb67.3 kb visible · 67,305 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
CnCOM N-term
CcCOM C-term
TEThioesterase (TE)
EEpimerization (E)
ECHEnoyl-CoA hydratase
AmTAminotransferase I/II
XPutative domain (X)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

11 steps · 10 edges
Step 1
start
+malonyl-CoA
Step 2M1
DMA15_34330
+4-hydroxyphenylgl…
Step 3M2
DMA15_34330
+3,5-dihydroxyphen…
Step 4M3
DMA15_34330
+Tryptophan
Step 5M4
DMA15_34335
+4-hydroxyphenylgl…
Step 6M5
DMA15_34340
+4-hydroxyphenylgl…
Step 7M6
DMA15_34340
+Tyrosine
Step 8M7
DMA15_34340
+Tyrosine
Step 9M8
DMA15_34345
+3,5-dihydroxyphen…
Step 10M9
DMA15_34355
+3,5-dihydroxyphen…
Step 11TE
DMA15_34355, (DMA15_343…
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12314-1start—
malonyl-CoA
O=C(C)O—
22314-2DMA15_34330M1
2314-1;4-hydroxyphenylglycine
from: 2314-1
OC(C(C1=CC=C(O)C=C1)NC(C)=O)=O—
32314-3DMA15_34330M2
2314-2;3,5-dihydroxyphenylglycine
from: 2314-2
OC(C(C1=CC(O)=CC(O)=C1)NC(C(C2=CC=C(O)C=C2)NC(C)=O)=O)=O—
42314-4DMA15_34330M3
2314-3;Tryptophan
from: 2314-3
OC(C(CC1=CNC2=C1C=CC=C2)NC(C(C3=CC(O)=CC(O)=C3)NC(C(C4=CC=C(O)C=C4)NC(C)=O)=O)=O)=O—
52314-5DMA15_34335M4
2314-4;4-hydroxyphenylglycine
from: 2314-4
OC(C(C1=CC=C(O)C=C1)NC(C(CC2=CNC3=C2C=CC=C3)NC(C(C4=CC(O)=CC(O)=C4)NC(C(C5=CC=C(O)C=C5)NC(C)=O)=O)=O)=O)=O—
62314-6DMA15_34340M5
2314-5;4-hydroxyphenylglycine
from: 2314-5
OC(C(C1=CC=C(O)C=C1)NC(C(C2=CC=C(O)C=C2)NC(C(CC3=CNC4=C3C=CC=C4)NC(C(C5=CC(O)=CC(O)=C5)NC(C(C6=CC=C(O)C=C6)NC(C)=O)=O)=O)=O)=O)=O—
72314-7DMA15_34340M6
2314-6;Tyrosine
from: 2314-6
OC(C(NC(C(C1=CC=C(O)C=C1)NC(C(C2=CC=C(O)C=C2)NC(C(CC3=CNC4=C3C=CC=C4)NC(C(C5=CC(O)=CC(O)=C5)NC(C(C6=CC=C(O)C=C6)NC(C)=O)=O)=O)=O)=O)=O)CC7=CC=C(O)C=C7)=O—
82314-8DMA15_34340M7
2314-7;Tyrosine
from: 2314-7
OC(C(CC1=CC=C(O)C=C1)NC(C(NC(C(C2=CC=C(O)C=C2)NC(C(C3=CC=C(O)C=C3)NC(C(CC4=CNC5=C4C=CC=C5)NC(C(C6=CC(O)=CC(O)=C6)NC(C(C7=CC=C(O)C=C7)NC(C)=O)=O)=O)=O)=O)=O)CC8=CC=C(O)C=C8)=O)=O—
92314-9DMA15_34345M8
2314-8;3,5-dihydroxyphenylglycine
from: 2314-8
OC(C(NC(C(CC1=CC=C(O)C=C1)NC(C(NC(C(C2=CC=C(O)C=C2)NC(C(C3=CC=C(O)C=C3)NC(C(CC4=CNC5=C4C=CC=C5)NC(C(C6=CC(O)=CC(O)=C6)NC(C(C7=CC=C(O)C=C7)NC(C)=O)=O)=O)=O)=O)=O)CC8=CC=C(O)C=C8)=O)=O)C9=CC(O)=CC(O)=C9)=O—
102314-10DMA15_34355M9
2314-9;3,5-dihydroxyphenylglycine
from: 2314-9
OC(C(NC(C(NC(C(CC1=CC=C(O)C=C1)NC(C(NC(C(C2=CC=C(O)C=C2)NC(C(C3=CC=C(O)C=C3)NC(C(CC4=CNC5=C4C=CC=C5)NC(C(C6=CC(O)=CC(O)=C6)NC(C(C7=CC=C(O)C=C7)NC(C)=O)=O)=O)=O)=O)=O)CC8=CC=C(O)C=C8)=O)=O)C9=CC(O)=CC(O)=C9)=O)C%10=CC(O)=CC(O)=C%10)=O—
112314DMA15_34355, (DMA15_34360, DMA15_34365, DMA15_34370)TE
2314-10
from: 2314-10
OC1=CC=C([C@@H](C(N[C@H](C(N[C@H](CC2=CNC3=CC4=CC=C32)C(N[C@H]5C(N[C@@H](C(N[C@@H]6CC7=CC=C(O)C8=C7)=O)C9=CC4=C(O)C(OC%10=CC=C(C[C@H](C(N[C@@H](C(N[C@H](C(O)=O)C%11=CC(O)=CC(O)=C%11)=O)C%12=CC(O)=CC(O)=C%128)=O)NC6=O)C=C%10)=C9)=O)=O)=O)C%13=CC(OC%14=CC5=CC=C%14O)=CC(O)=C%13)=O)NC(C)=O)C=C1—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture