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BGC0002308PKS

camporidine A;camporidine B

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
other (other);PKS (Unknown)
Total steps
17
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map20 genes · 52,415 bp

ERKSATKSATKSATKSATKSATKSATAmTCALER10 kb52.4 kb visible · 52,415 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
TDTerminal reductase
CALCoA-ligase (CAL)
AmTAminotransferase III

Pathway Graphsteps arranged in biosynthetic order

17 steps · 16 edges
Step 1Load
camE
+malonyl-CoA
Step 2M1
camE
+malonyl-CoA
Step 3M2
camE
+malonyl-CoA
Step 4M3
camD
+malonyl-CoA
Step 5M4
camD
+malonyl-CoA
Inactive: KR
Step 6M5
camC
+2-carboxyoctanoyl…
Step 7TE
camC
Step 8
?
Step 9
camM
Step 10
Step 11
camJ
Step 12
camK,camL
Step 13
camF,camP
Step 14
camG/camH/camI/camT
Step 15
camG/camH/camI/camT
Step 16
camG/camH/camI/camT
Step 17
camG/camI/camT
+2308(1)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12308-1camELoading
malonyl-CoA
OC(C)=O—
22308-2camEM1
2308-1;malonyl-CoA
from: 2308-1
OC(/C=C/C)=O—
32308-3camEM2
2308-2;malonyl-CoA
from: 2308-2
OC(/C=C/C=C/C)=O—
42308-4camDM3
2308-3;malonyl-CoA
from: 2308-3
OC(/C=C/C=C/C=C/C)=O—
52308-5camDM4
2308-4;malonyl-CoA
from: 2308-4
OC(CC(/C=C/C=C/C=C/C)=O)=O{'Inactive':['KR']}
62308-6camCM5
2308-5;2-carboxyoctanoyl extender unit
from: 2308-5
O=C/C(CCCCCC)=C/CC(/C=C/C=C/C=C/C)=O—
72308-7camCTE
2308-6
from: 2308-6
O=C/C(CCCCCC)=C/CC(/C=C/C=C/C=C/C)=O—
82308-8?—
2308-7
from: 2308-7
O=CC(CCC(/C=C/C=C/C=C/C)=O)CCCCCC—
92308-9camM—
2308-8
from: 2308-8
NCC(CCC(/C=C/C=C/C=C/C)=O)CCCCCC—
102308-10—
2308-9
from: 2308-9
C/C=C/C=C/C=C/C1=NCC(CCCCCC)CC1—
112308-11camJ—
2308-10
from: 2308-10
C/C=C/C=C/C=C/C1=NCC(CCCCCC)C=C1—
122308-12camK,camL—
2308-11
from: 2308-11
C/C=C/C=C/C=C/C1=NCC(CCCCCC)C2C1C2—
132308-13camF,camP—
2308-12
from: 2308-12
C/C=C/C=C(C=C1)/C23C1NCC(CCCCCC)C2O3—
142308-14camG/camH/camI/camT—
2308-13
from: 2308-13
CCCCCCC1CNC2C3(/C(C=C2)=C/C=C/CO)C1O3—
152308-15camG/camH/camI/camT—
2308-14
from: 2308-14
CCCCCCC1CNC2C3(/C(C=C2)=C/C=C/C=O)C1O3—
162308(1)camG/camH/camI/camT—
2308-15
from: 2308-15
CCCCCCC1CNC2C3(/C(C=C2)=C/C=C/C(O)=O)C1O3—
172308(2)camG/camI/camT—
2308(1)
CCCCCCC1CN(O)C2C3(/C(C=C2)=C/C=C/C(O)=O)C1O3—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture