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BGC0002300NRPS

albomycin delta2;albomycin delta1;albomycin epsilon

Producing organism
Streptomyces sp. ATCC 700974
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type 1)
Total steps
17
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map20 genes · 28,137 bp

ACC5 kb28.1 kb visible · 28,137 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)

Pathway Graphsteps arranged in biosynthetic order

17 steps · 20 edges
Step 1
AFJ20768.1
+L-ornithine
Step 5
start
+?
Step 2
AFJ20767.1
Step 6
AFJ20773.1
+L-Threonine
Step 3
AFJ20782.1
Step 7
AFJ20770.1
Step 4
AFJ20782.1
Step 8
AFJ20774.1,AFJ20771.1
Step 12
?
Step 9
AFJ20776.1,?
+Serine
Step 13
AFJ20776.1,?
Step 10
AFJ20775.1
Step 14
AFJ20775.1
Step 11
AFJ20769.1
Step 15
AFJ20769.1
Step 16
AFJ20769.1
Step 17
AFJ20769.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12300-1AFJ20768.1—
L-ornithine
N[C@H](C(O)=O)CCCNO—
22300-2AFJ20767.1—
2300-1
from: 2300-1
N[C@H](C(O)=O)CCCN(O)C(C)=O—
32300-3AFJ20782.1—
2300-2
from: 2300-2
O=C(NC(CCCNO)C(O)=O)C(N)CCCNO—
42300-4AFJ20782.1—
2300-3;2300-2
from: 2300-3, 2300-2
O=C(O)C(NC(C(NC(C(N)CCCNO)=O)CCCNO)=O)CCCNO—
52300-5start—
?
OC(O)[C@@]1([H])SC(N2C=CC(N)=NC2=O)C(O)C1O—
62300-6AFJ20773.1—
2300-5;L-Threonine
from: 2300-5
O[C@@H]([C@@H](C(O)=O)N)[C@@]1([H])SC(N2C=CC(N)=NC2=O)C(O)C1O—
72300-7AFJ20770.1—
2300-6
from: 2300-6
O[C@@H]([C@H](C(O)=O)N)[C@@]1([H])SC(N2C=CC(N)=NC2=O)C(O)C1O—
82300-8AFJ20774.1,AFJ20771.1—
2300-7
from: 2300-7
O[C@@H]([C@H](C(O)=O)N)[C@@]1([H])SC(N(C(N2C)=O)C=CC2=NC(N)=O)C(O)C1O—
92300-9AFJ20776.1,?—
2300-8;Serine
from: 2300-8
O[C@@H]([C@@H](NC([C@H](CO)N)=O)C(O)=O)[C@@]1([H])SC(N(C(N2C)=O)C=CC2=NC(N)=O)C(O)C1O—
102300-10AFJ20775.1—
2300-9
from: 2300-9
O[C@@H]([C@@H](NC([C@H](CO)N)=O)C(O)=O)[C@@]1([H])SC(N(C(N2C)=O)C=CC2=NC(N)=O)C(O)C1O—
112300(1)AFJ20769.1—
2300-10;2300-4
from: 2300-10, 2300-4
O[C@@H]([C@@H](NC([C@H](CO)NC([C@H](CCCN1C(C)=O2)NC([C@H]3NC([C@H](CCCN4C(C)=O[Fe]25(O1)(O4)ON(C(C)=O5)CCC3)N)=O)=O)=O)=O)C(O)=O)[C@@]6([H])SC(N(C(N7C)=O)C=CC7=NC(N)=O)C(O)C6O—
122300-11?—
2300-7
from: 2300-7
O[C@@H]([C@H](C(O)=O)N)[C@@]1([H])SC(N(C(N2C)=O)C=CC2=[R])C(O)C1O—
132300-12AFJ20776.1,?—
2300-11
from: 2300-11
O[C@@H]([C@@H](NC([C@H](CO)N)=O)C(O)=O)[C@@]1([H])SC(N(C(N2C)=O)C=CC2=[R])C(O)C1O—
142300-13AFJ20775.1—
2300-12
from: 2300-12
O[C@@H]([C@@H](NC([C@H](CO)N)=O)C(O)=O)[C@@]1([H])SC(N(C(N2C)=O)C=CC2=[R])C(O)C1O—
152300-14AFJ20769.1—
2300-4;2300-13
from: 2300-4, 2300-13
O[C@@H]([C@@H](NC([C@H](CO)NC([C@H](CCCN1C(C)=O2)NC([C@H]3NC([C@H](CCCN4C(C)=O[Fe]25(O1)(O4)ON(C(C)=O5)CCC3)N)=O)=O)=O)=O)C(O)=O)[C@@]6([H])SC(N(C(N7C)=O)C=CC7=[R])C(O)C6O—
162300(2)AFJ20769.1—
2300-4;2300-13
from: 2300-4, 2300-13
O[C@@H]([C@@H](NC([C@H](CO)NC([C@H](CCCN1C(C)=O2)NC([C@H]3NC([C@H](CCCN4C(C)=O[Fe]25(O1)(O4)ON(C(C)=O5)CCC3)N)=O)=O)=O)=O)C(O)=O)[C@@]6([H])SC(N(C(N7C)=O)C=CC7=O)C(O)C6O—
172300(3)AFJ20769.1—
2300-4;2300-13
from: 2300-4, 2300-13
O[C@@H]([C@@H](NC([C@H](CO)NC([C@H](CCCN1C(C)=O2)NC([C@H]3NC([C@H](CCCN4C(C)=O[Fe]25(O1)(O4)ON(C(C)=O5)CCC3)N)=O)=O)=O)=O)C(O)=O)[C@@]6([H])SC(N(C(N7C)=O)C=CC7=N)C(O)C6O—
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