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BGC0002293NRPS

ohmyungsamycin A;ohmyungsamycin B

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type 1)
Total steps
19
DOI
MIBiG entry
View on MIBiG ↗
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C75H119N13O161457.89 Da

Gene Cluster Map16 genes · 56,950 bp

ACACACACACACACACACACACA10 kb56.9 kb visible · 56,950 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Other
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

19 steps · 18 edges
Step 1M1
ohmA
+N-Methyl-L-Valine
Step 9
Start
+L-Tryptophan
Step 2M2
ohmA
+(L-Valine/L-Isole…
Step 10
ohmK
Step 3M3
ohmA
+L-Threonine
Step 11
ohmJ
Step 4M4
ohmA
+N-Methyl-Threonine
Step 5M5
ohmA
+L-Valine
Step 6M6
ohmA
+N-Methyl-L-Leucine
Step 7M7
ohmA
+L-Valine
Step 8M8
ohmA
+N-Methyl-L-Valine
Step 12M9
ohmA
Step 13M10
ohmA
+L-Valine
Step 14M11
ohmA
+L-Phenylalanine
Step 15
ohmL
Step 16M12
ohmA
+L-Valine
Step 17TE
ohmA
Step 18TE
ohmA
Step 19TE
ohmA
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions19 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12293-1ohmAM1
N-Methyl-L-Valine
OC([C@H](C(C)C)NC)=O—
22293-2ohmAM2
2293-1;(L-Valine/L-Isoleucine)
from: 2293-1
OC([C@H]([C@@H](C[R])C)NC([C@H](C(C)C)NC)=O)=O—
32293-3ohmAM3
2293-2;L-Threonine
from: 2293-2
OC([C@H]([C@H](O)C)NC([C@H]([C@@H](C[R])C)NC([C@H](C(C)C)NC)=O)=O)=O—
42293-4ohmAM4
2293-3;N-Methyl-Threonine
from: 2293-3
OC([C@H]([C@@H](C)O)N(C)C([C@H]([C@H](O)C)NC([C@H]([C@@H](C[R])C)NC([C@H](C(C)C)NC)=O)=O)=O)=O—
52293-5ohmAM5
2293-4;L-Valine
from: 2293-4
OC([C@@H](NC([C@H]([C@@H](C)O)N(C)C([C@H]([C@H](O)C)NC([C@H]([C@@H](C[R])C)NC([C@H](C(C)C)NC)=O)=O)=O)=O)C(C)C)=O—
62293-6ohmAM6
2293-5;N-Methyl-L-Leucine
from: 2293-5
OC([C@H](CC(C)C)N(C([C@@H](NC([C@H]([C@@H](C)O)N(C)C([C@H]([C@H](O)C)NC([C@H]([C@@H](C[R])C)NC([C@H](C(C)C)NC)=O)=O)=O)=O)C(C)C)=O)C)=O—
72293-7ohmAM7
2293-6;L-Valine
from: 2293-6
OC([C@H](C(C)C)NC([C@H](CC(C)C)N(C([C@@H](NC([C@H]([C@@H](C)O)N(C)C([C@H]([C@H](O)C)NC([C@H]([C@@H](C[R])C)NC([C@H](C(C)C)NC)=O)=O)=O)=O)C(C)C)=O)C)=O)=O—
82293-8ohmAM8
2293-7;N-Methyl-L-Valine
from: 2293-7
OC([C@H](C(C)C)N(C)C([C@H](C(C)C)NC([C@H](CC(C)C)N(C([C@@H](NC([C@H]([C@@H](C)O)N(C)C([C@H]([C@H](O)C)NC([C@H]([C@@H](C[R])C)NC([C@H](C(C)C)NC)=O)=O)=O)=O)C(C)C)=O)C)=O)=O)=O—
92293-9Start—
L-Tryptophan
OC([C@@H](N)CC1=CNC2=C1C=CC=C2)=O—
102293-10ohmK—
2293-9
from: 2293-9
OC1=CC=CC2=C1C(C[C@H](N)C(O)=O)=CN2—
112293-11ohmJ—
2293-10
from: 2293-10
COC1=CC=CC2=C1C(C[C@H](N)C(O)=O)=CN2—
122293-12ohmAM9
2293-8;2293-11
from: 2293-8, 2293-11
OC([C@H](CC1=CNC2=C1C(OC)=CC=C2)N(C)C([C@H](C(C)C)N(C)C([C@H](C(C)C)NC([C@H](CC(C)C)N(C([C@@H](NC([C@H]([C@@H](C)O)N(C)C([C@H]([C@H](O)C)NC([C@H]([C@@H](C[R])C)NC([C@H](C(C)C)NC)=O)=O)=O)=O)C(C)C)=O)C)=O)=O)=O)=O—
132293-13ohmAM10
2293-12;L-Valine
from: 2293-12
OC([C@H](C(C)C)NC([C@H](CC1=CNC2=C1C(OC)=CC=C2)N(C)C([C@H](C(C)C)N(C)C([C@H](C(C)C)NC([C@H](CC(C)C)N(C([C@@H](NC([C@H]([C@@H](C)O)N(C)C([C@H]([C@H](O)C)NC([C@H]([C@@H](C[R])C)NC([C@H](C(C)C)NC)=O)=O)=O)=O)C(C)C)=O)C)=O)=O)=O)=O)=O—
142293-14ohmAM11
2293-13;L-Phenylalanine
from: 2293-13
OC([C@H](CC1=CC=CC=C1)NC([C@H](C(C)C)NC([C@H](CC2=CNC3=C2C(OC)=CC=C3)N(C)C([C@H](C(C)C)N(C)C([C@H](C(C)C)NC([C@H](CC(C)C)N(C([C@@H](NC([C@H]([C@@H](C)O)N(C)C([C@H]([C@H](O)C)NC([C@H]([C@@H](C[R])C)NC([C@H](C(C)C)NC)=O)=O)=O)=O)C(C)C)=O)C)=O)=O)=O)=O)=O)=O—
152293-15ohmL—
2293-14
from: 2293-14
OC([C@H]([C@@H](O)C1=CC=CC=C1)NC([C@H](C(C)C)NC([C@H](CC2=CNC3=C2C(OC)=CC=C3)N(C)C([C@H](C(C)C)N(C)C([C@H](C(C)C)NC([C@H](CC(C)C)N(C([C@@H](NC([C@H]([C@@H](C)O)N(C)C([C@H]([C@H](O)C)NC([C@H]([C@@H](C[R])C)NC([C@H](C(C)C)NC)=O)=O)=O)=O)C(C)C)=O)C)=O)=O)=O)=O)=O)=O—
162293-16ohmAM12
2293-15;L-Valine
from: 2293-15
O=C(O)[C@H](C(C)C)NC([C@H]([C@@H](O)C1=CC=CC=C1)NC([C@H](C(C)C)NC([C@H](CC2=CNC3=C2C(OC)=CC=C3)N(C)C([C@H](C(C)C)N(C)C([C@H](C(C)C)NC([C@H](CC(C)C)N(C([C@@H](NC([C@H]([C@@H](C)O)N(C)C([C@H]([C@H](O)C)NC([C@H]([C@@H](C[R])C)NC([C@H](C(C)C)NC)=O)=O)=O)=O)C(C)C)=O)C)=O)=O)=O)=O)=O)=O—
172293-17ohmATE
2293-16
from: 2293-16
CN[C@H](C(N[C@@H]([C@@H](C)C[R])C(N[C@H](C(N(C)[C@@H]([C@@H](C)O)C(N[C@H](C(N([C@@H](CC(C)C)C(N[C@H](C(N([C@@H](C(C)C)C(N([C@H](C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C1=O)C(C)C)=O)[C@@H](C2=CC=CC=C2)O)=O)=O)CC3=CNC4=C3C(OC)=CC=C4)C)=O)C)=O)C(C)C)=O)C)=O)C(C)C)=O)=O)[C@H](O1)C)=O)=O)C(C)C—
182293(1)ohmATE
2293-16
from: 2293-16
CN[C@H](C(N[C@@H](C(C)C[H])C(N[C@H](C(N(C)[C@@H]([C@@H](C)O)C(N[C@H](C(N([C@@H](CC(C)C)C(N[C@H](C(N([C@@H](C(C)C)C(N([C@H](C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C1=O)C(C)C)=O)[C@@H](C2=CC=CC=C2)O)=O)=O)CC3=CNC4=C3C(OC)=CC=C4)C)=O)C)=O)C(C)C)=O)C)=O)C(C)C)=O)=O)[C@H](O1)C)=O)=O)C(C)C—
192293(2)ohmATE
2293-16
from: 2293-16
CN[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(N(C)[C@@H]([C@@H](C)O)C(N[C@H](C(N([C@@H](CC(C)C)C(N[C@H](C(N([C@@H](C(C)C)C(N([C@H](C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C1=O)C(C)C)=O)[C@@H](C2=CC=CC=C2)O)=O)=O)CC3=CNC4=C3C(OC)=CC=C4)C)=O)C)=O)C(C)C)=O)C)=O)C(C)C)=O)=O)[C@H](O1)C)=O)=O)C(C)C—
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