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BGC0002291PKS

efomycin K;efomycin L

Producing organism
Streptomyces sp. M56
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
11
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map24 genes · 63,223 bp

ERKSKSKSATKSKSKSKSATKS10 kb63.2 kb visible · 63,223 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

11 steps · 10 edges
Step 1Load
CFP59_01557
+Malonyl-CoA
Step 2M1
CFP59_01557
+(methylmalonyl-Co…
Inactive: DH
Step 3M2
CFP59_01557
+malonyl-CoA
{'Domain_Reuse': ['DH', (C…
Step 4M3
CFP59_01556
+methylmalonyl-CoA
Inactive: KR
Step 5M4
CFP59_01555
+methylmalonyl-CoA
Step 6M5
CFP59_01554
+methylmalonyl-CoA
Step 7M6
CFP59_01554
+malonyl-CoA
Step 8M7
CFP59_01553
+malonyl-CoA
Step 9TE
CFP59_01553
Step 10TE
CFP59_01553
Step 11TE
CFP59_01553
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12291-1CFP59_01557Loading
Malonyl-CoA
OC(C)=O—
22291-2CFP59_01557M1
2291-1;(methylmalonyl-CoA/ethylmalonyl-CoA)
from: 2291-1
OC([C@H]([R])[C@H](O)C)=O{'Inactive':['DH']}
32291-3CFP59_01557M2
2291-2;malonyl-CoA
from: 2291-2
OC(/C=C/[C@H]([R])[C@H](O)C)=O{'Domain_Reuse': ['DH', (CFP…
42291-4CFP59_01556M3
2291-3;methylmalonyl-CoA
from: 2291-3
OC([C@H](C)C(/C=C/[C@H]([R])[C@H](O)C)=O)=O{'Inactive':['KR']}
52291-5CFP59_01555M4
2291-4;methylmalonyl-CoA
from: 2291-4
OC([C@@H](C)[C@@H](O)[C@H](C)C(/C=C/[C@H]([R])[C@H](O)C)=O)=O—
62291-6CFP59_01554M5
2291-5;methylmalonyl-CoA
from: 2291-5
OC([C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@H](C)C(/C=C/[C@H]([R])[C@H](O)C)=O)=O—
72291-7CFP59_01554M6
2291-6;malonyl-CoA
from: 2291-6
OC(/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@H](C)C(/C=C/[C@H]([R])[C@H](O)C)=O)=O—
82291-8CFP59_01553M7
2291-7;malonyl-CoA
from: 2291-7
O=C(O)/C=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@H](C)C(/C=C/[C@H]([R])[C@H](O)C)=O—
92291-9CFP59_01553TE
2291-8;2291-8
from: 2291-8, 2291-8
O=C(/C=C/C=C/[C@H](C)[C@H](O1)[C@@H](C)[C@@H](O)[C@H](C)C(/C=C/[C@H]([R*])[C@H](O)C)=O)O[C@H]([C@@H](C)[C@@H](O)[C@H](C)C(/C=C/[C@H]([R])[C@H](O)C)=O)[C@@H](C)/C=C/C=C/C1=O—
102291(1)CFP59_01553TE
2291-8;2291-8
from: 2291-8, 2291-8
O=C(/C=C/C=C/[C@H](C)[C@H](O1)[C@@H](C)[C@@H](O)[C@H](C)C(/C=C/[C@H](C)[C@H](O)C)=O)O[C@H]([C@@H](C)[C@@H](O)[C@H](C)C(/C=C/[C@H](C)[C@H](O)C)=O)[C@@H](C)/C=C/C=C/C1=O—
112291(2)CFP59_01553TE
2291-8;2291-8
from: 2291-8, 2291-8
O=C(/C=C/C=C/[C@H](C)[C@H](O1)[C@@H](C)[C@@H](O)[C@H](C)C(/C=C/[C@H](CC)[C@H](O)C)=O)O[C@H]([C@@H](C)[C@@H](O)[C@H](C)C(/C=C/[C@H](C)[C@H](O)C)=O)[C@@H](C)/C=C/C=C/C1=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture