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BGC0002288NRPS

ashimide A;ashimide B

Producing organism
Streptomyces sp. NA03103
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type 1)
Total steps
17
DOI
MIBiG entry
View on MIBiG ↗
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C19H20N4O10464.39 Da

Gene Cluster Map19 genes · 31,330 bp

CyACACATEAA5 kb31.3 kb visible · 31,330 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
CyHeterocyclization (Cy)

Pathway Graphsteps arranged in biosynthetic order

17 steps · 16 edges
Step 1
Start
+Chrosimate
Step 2
HUT15_07595
Step 3
HUT15_07605
Step 4
HUT15_07645
Step 5Load
HUT15_07650, ?
Step 6M1
HUT15_07570, HUT15_07575
+Glycine
Step 7M2
HUT15_07620
+Glycine
Step 8M3
HUT15_07625
+Alanine
Step 9
HUT15_07635
Step 10
HUT15_07610
Step 11
HUT15_07630
Step 12
HUT15_07630
Step 13TE
HUT15_07625
Step 14
HUT15_07600
Step 15
Step 16
Step 17
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions17 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12288-1Start—
Chrosimate
C=C(C(O)=O)OC1C(C=CC(C(O)=O)=C1)O—
22288-2HUT15_07595—
2288-1
from: 2288-1
C=C(C(O)=O)OC1C=CC=C(C(O)=O)C1N—
32288-3HUT15_07605—
2288-2
from: 2288-2
C=C(C(O)=O)OC1=C(N)C(C(O)=O)=CC=C1—
42288-4HUT15_07645—
2288-3
from: 2288-3
OC(C1=CC=CC(OC2=C)=C1NC2=O)=O—
52288-5HUT15_07650, ?Loading
2288-4
from: 2288-4
OC(C1=CC=CC(OC2=C)=C1NC2=O)=O—
62288-6HUT15_07570, HUT15_07575M1
2288-5;Glycine
from: 2288-5
OC([C@@H](N)COC(C1=CC=CC(OC2=C)=C1NC2=O)=O)=O—
72288-7HUT15_07620M2
2288-6;Glycine
from: 2288-6
OC(CNC([C@@H](N)COC(C1=CC=CC(OC2=C)=C1NC2=O)=O)=O)=O—
82288-8HUT15_07625M3
2288-7;Alanine
from: 2288-7
O=C(O)C(C)NC(CNC([C@@H](N)COC(C1=CC=CC(OC2=C)=C1NC2=O)=O)=O)=O—
92288-9HUT15_07635—
2288-8
from: 2288-8
O=C(O)C(C)N(C)C(CNC([C@@H](N)COC(C1=CC=CC(OC2=C)=C1NC2=O)=O)=O)=O—
102288-10HUT15_07610—
2288-9
from: 2288-9
O=C(O)C(N(C)C(CNC([C@@H](N)COC(C1=CC=CC(OC2=C)=C1NC2=O)=O)=O)=O)=C—
112288-11HUT15_07630—
2288-10
from: 2288-10
O=C(O)/C(C[R])=[N+](C)/C(CNC([C@@H](N)COC(C1=CC=CC(OC2=C)=C1NC2=O)=O)=O)=O—
122288-12HUT15_07630—
2288-11
from: 2288-11
O=C([C@@H](N)COC(C1=CC=CC(OC2=C)=C1NC2=O)=O)N3[C@@](C(O)=O)(C[R])N(C)C(C3)=O—
132288-13HUT15_07625TE
2288-12
from: 2288-12
O=C(C1=CC=CC(OC2=C)=C1NC2=O)OC[C@H]3C(N(CC(N4C)=O)[C@]4(C[R])C(N3)=O)=O—
142288-14HUT15_07600—
2288-13
from: 2288-13
O=C(C1=CC=CC(OC23CO3)=C1NC2=O)OC[C@H]4C(N(CC(N5C)=O)[C@]5(C[R])C(N4)=O)=O—
152288-15—
2288-14
from: 2288-14
O=C(C1=CC=CC(OC2(O)CO)=C1NC2=O)OC[C@H]3C(N(CC(N4C)=O)[C@]4(C[R])C(N3)=O)=O—
162288(1)—
2288-14
from: 2288-14
O=C(C1=CC=CC(OC2(O)CO)=C1NC2=O)OC[C@H]3C(N(CC(N4C)=O)[C@]4(CO)C(N3)=O)=O—
172288(2)—
2288-14
from: 2288-14
O=C(C1=CC=CC(OC2(O)CO)=C1NC2=O)OC[C@H]3C(N(CC(N4C)=O)[C@]4(CCl)C(N3)=O)=O—
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