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BGC0002124PKS

SF2487

Producing organism
Actinomadura verrucosospora
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Streptosporangiales›Thermomonosporaceae›Actinomadura
Biosynthetic class
PKS (Type 1)
Total steps
31
DOI
MIBiG entry
View on MIBiG ↗
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SF2487

Gene Cluster Map47 genes · 126,669 bp

20 kb126.7 kb visible · 126,669 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
FkFkbH-like
ACPSACP synthase

Pathway Graphsteps arranged in biosynthetic order

31 steps · 30 edges
Step 1
Start
+1,3-bisphosphogly…
Step 7Load
ACTIVE_1800
+methylmalonyl-CoA
Step 2
ACTIVE_1791;ACTIVE_1793
Step 6
ACTIVE_1798;ACTIVE_1797
Step 8M1
ACTIVE_1800
+malonyl-CoA
Step 3
ACTIVE_1794
Step 9M2
ACTIVE_1800
+malonyl-CoA
Step 4
ACTIVE_1792
Step 10M3
ACTIVE_1772
+methylmalonyl-CoA
Step 5
ACTIVE_1791
Step 11M4
ACTIVE_1772
+methylmalonyl-CoA
Step 12M5
ACTIVE_1780
+malonyl-CoA
Inactive: DH
Step 13M6
ACTIVE_1781
+methylmalonyl-CoA
Step 14M7
ACTIVE_1781
+methylmalonyl-CoA
Step 15M8
ACTIVE_1783
+malonyl-CoA
Step 16M9
ACTIVE_1783
+methylmalonyl-CoA
Step 17M10
ACTIVE_1783
+malonyl-CoA
Step 18M11
ACTIVE_1784
+methylmalonyl-CoA
Step 19M12
ACTIVE_1784
+methylmalonyl-CoA
Inactive: DH
Step 20M13
ACTIVE_1784
+Methoxymalonyl-AC…
Step 21M14
ACTIVE_1796
+malonyl-CoA
Inactive: KR
Step 22
ACTIVE_1789
Step 23
ACTIVE_1786
Step 24
ACTIVE_1776
Step 25
ACTIVE_1776
Step 26
ACTIVE_1788
Step 27
ACTIVE_1787
Step 28
ACTIVE_1775
Step 29
ACTIVE_1795
Step 30
ACTIVE_1773
Step 31
ACTIVE_1774
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions31 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12124-1Start—
1,3-bisphosphoglycerate
O[C@H](OP([O-])([O-])=O)C(OP([O-])([O-])=O)=O—
22124-2ACTIVE_1791;ACTIVE_1793—
2124-1
from: 2124-1
OC[C@H](C(O)=O)O—
32124-3ACTIVE_1794—
2124-2
from: 2124-2
O=C[C@H](C(O)=O)O—
42124-4ACTIVE_1792—
2124-3
from: 2124-3
O=C(O)C(C(O)=O)O—
52124-5ACTIVE_1791—
2124-4
from: 2124-4
O=C(O)C(C(O)=O)OC—
62124-6ACTIVE_1798;ACTIVE_1797—
2124-1
from: 2124-1
OC[C@H](C(O)=O)O—
72124-7ACTIVE_1800Loading
methylmalonyl-CoA
OC(CC)=O—
82124-8ACTIVE_1800M1
2124-7;malonyl-CoA
from: 2124-7
OC(/C=C/CC)=O—
92124-9ACTIVE_1800M2
2124-8;malonyl-CoA
from: 2124-8
OC(CC/C=C/CC)=O—
102124-10ACTIVE_1772M3
2124-9;methylmalonyl-CoA
from: 2124-9
OC(/C(C)=C/CC/C=C/CC)=O—
112124-11ACTIVE_1772M4
2124-10;methylmalonyl-CoA
from: 2124-10
OC([C@H](C)C/C(C)=C/CC/C=C/CC)=O—
122124-12ACTIVE_1780M5
2124-11;malonyl-CoA
from: 2124-11
OC(C[C@@H](O)[C@H](C)C/C(C)=C/CC/C=C/CC)=O{'Inactive':['DH']}
132124-13ACTIVE_1781M6
2124-12;methylmalonyl-CoA
from: 2124-12
OC(/C=C/C[C@@H](O)[C@H](C)C/C(C)=C/CC/C=C/CC)=O—
142124-14ACTIVE_1781M7
2124-13;methylmalonyl-CoA
from: 2124-13
OC([C@H](C)[C@@H](O)/C=C/C[C@@H](O)[C@H](C)C/C(C)=C/CC/C=C/CC)=O—
152124-15ACTIVE_1783M8
2124-14;malonyl-CoA
from: 2124-14
OC(CC[C@H](C)[C@@H](O)/C=C/C[C@@H](O)[C@H](C)C/C(C)=C/CC/C=C/CC)=O—
162124-16ACTIVE_1783M9
2124-15;methylmalonyl-CoA
from: 2124-15
OC(/C(C)=C/CC[C@H](C)[C@@H](O)/C=C/C[C@@H](O)[C@H](C)C/C(C)=C/CC/C=C/CC)=O—
172124-17ACTIVE_1783M10
2124-16;malonyl-CoA
from: 2124-16
OC(/C=C/C(C)=C/CC[C@H](C)[C@@H](O)/C=C/C[C@@H](O)[C@H](C)C/C(C)=C/CC/C=C/CC)=O—
182124-18ACTIVE_1784M11
2124-17;methylmalonyl-CoA
from: 2124-17
OC([C@H](C)C/C=C/C(C)=C/CC[C@H](C)[C@@H](O)/C=C/C[C@@H](O)[C@H](C)C/C(C)=C/CC/C=C/CC)=O—
192124-19ACTIVE_1784M12
2124-18;methylmalonyl-CoA
from: 2124-18
OC([C@H](C)[C@@H](O)[C@H](C)C/C=C/C(C)=C/CC[C@H](C)[C@@H](O)/C=C/C[C@@H](O)[C@H](C)C/C(C)=C/CC/C=C/CC)=O{'Inactive':['DH']}
202124-20ACTIVE_1784M13
2124-19;Methoxymalonyl-ACP(2124-5)
from: 2124-19
OC(/C(OC)=C/[C@H](C)[C@@H](O)[C@H](C)C/C=C/C(C)=C/CC[C@H](C)[C@@H](O)/C=C/C[C@@H](O)[C@H](C)C/C(C)=C/CC/C=C/CC)=O—
212124-21ACTIVE_1796M14
2124-20;malonyl-CoA
from: 2124-20
O=C(O)CC(/C(OC)=C/[C@H](C)[C@@H](O)[C@H](C)C/C=C/C(C)=C/CC[C@H](C)[C@@H](O)/C=C/C[C@@H](O)[C@H](C)C/C(C)=C/CC/C=C/CC)=O{'Inactive':['KR']}
222124-22ACTIVE_1789—
2124-21;2124-6
from: 2124-21, 2124-6
O[C@H](/C(C)=C/C[C@H](O)[C@@H](C/C(C)=C/CC/C=C/CC)C)[C@@H](C)CC/C=C(C)/C=C/C[C@@H](C)[C@@H](O)[C@@H](C)/C=C(C(C1=C(O)[C@@H](CO)OC1=O)=O)\OC—
232124-23ACTIVE_1786—
2124-22
from: 2124-22
O[C@H](/C(C)=C/C[C@H](O)[C@@H](C[C@]([C@H]1CC[C@H](O2)[C@@H]2CC)(O1)C)C)[C@@H](C)CC/C=C(C)/C=C/C[C@@H](C)[C@@H](O)[C@@H](C)/C=C(C(C3=C(O)[C@@H](CO)OC3=O)=O)\OC—
242124-24ACTIVE_1776—
2124-23
from: 2124-23
O[C@H](/C(C)=C/C[C@@](O1)([H])[C@@H](C[C@@]1(C)[C@H](O)CC[C@H](O2)[C@@H]2CC)C)[C@@H](C)CC/C=C(C)/C=C/C[C@@H](C)[C@@H](O)[C@@H](C)/C=C(C(C3=C(O)[C@@H](CO)OC3=O)=O)\OC—
252124-25ACTIVE_1776—
2124-24
from: 2124-24
O[C@H](/C(C)=C/C[C@@](O1)([H])[C@@H](C[C@@]1(C)[C@@](O2)([H])CC[C@@]2([H])[C@H](O)CC)C)[C@@H](C)CC/C=C(C)/C=C/C[C@@H](C)[C@@H](O)[C@@H](C)/C=C(C(C3=C(O)[C@@H](CO)OC3=O)=O)\OC—
262124-26ACTIVE_1788—
2124-25
from: 2124-25
O[C@H](/C(C)=C/C[C@@](O1)([H])[C@@H](C[C@@]1(C)[C@@](O2)([H])CC[C@@]2([H])[C@H](O)CC)C)[C@@H](C)CC/C=C(C)/C=C/C[C@@H](C)[C@@H](O)[C@@H](C)/C=C(C(C3=C(O)[C@@H](COC(C)=O)OC3=O)=O)\OC—
272124-27ACTIVE_1787—
2124-26
from: 2124-26
O[C@H](/C(C)=C/C[C@@](O1)([H])[C@@H](C[C@@]1(C)[C@@](O2)([H])CC[C@@]2([H])[C@H](O)CC)C)[C@@H](C)CC/C=C(C)/C=C/C[C@@H](C)[C@@H](O)[C@@H](C)/C=C(C(C3=C(O)C(OC3=O)=C)=O)\OC—
282124-28ACTIVE_1775—
2124-27
from: 2124-27
O[C@H](/C(C)=C/C[C@@](O1)([H])[C@@H](C[C@@]1(C)[C@@](O2)([H])CC[C@@]2([H])[C@H](O)CC)C)[C@@H](C)CC/C=C(CO)/C=C/C[C@@H](C)[C@@H](O)[C@@H](C)/C=C(C(C3=C(O)C(OC3=O)=C)=O)\OC—
292124-29ACTIVE_1795—
2124-28
from: 2124-28
O[C@@H](/C=C/[C@H](C)[C@@](O1)([H])[C@@H](C[C@@]1(C)[C@@](O2)([H])CC[C@@]2([H])[C@H](O)CC)C)[C@@H](C)CC/C=C(CO)/[C@]3([H])[C@](C[C@@H](C)[C@@H](O)[C@H]4C)([H])[C@@]4([H])[C@H](OC)/C(O3)=C5C(C(OC\5=O)=C)=O—
302124-30ACTIVE_1773—
2124-29
from: 2124-29
C[C@@H](CC1)[C@](/C(C)=C/C[C@@](O2)([H])[C@@H](C[C@@]2(C)[C@@](O3)([H])CC[C@@]3([H])[C@H](O)CC)C)([H])O[C@@]1([H])/C(CO)=C/[C@@](C[C@@H](C)[C@@H](O)[C@H]4C)([H])[C@]4([H])[C@H](OC)C(C5=C(O)C(OC5=O)=C)=O—
312124ACTIVE_1774—
2124-30
from: 2124-30
C[C@@H](CC1)[C@](/C(C)=C/C[C@@](O2)([H])[C@@H](C[C@@]2(C)[C@@](O3)([H])CC[C@@]3([H])[C@H](O)CC)C)([H])O[C@@]1([H])/C(CO)=C/[C@@](C[C@@H](C)[C@@H](O)[C@H]4CO)([H])[C@]4([H])[C@H](OC)C(C5=C(O)C(OC5=O)=C)=O—
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