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BGC0002109NRPS

kitacinnamycin A;kitacinnamycin B;kitacinnamycin C;kitacinnamycin D;kitacinnamycin E;kitacinnamycin F

Producing organism
Kitasatospora sp.
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Kitasatospora
Biosynthetic class
NRPS (Type 1)
Total steps
26
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map42 genes · 76,824 bp

AAAAAAAAAA20 kb76.8 kb visible · 76,824 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CnCOM N-term
TEThioesterase (TE)
EEpimerization (E)
MTMethyltransferase
NADNAD-binding
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

26 steps · 29 edges
Step 1
QDJ74266.1,QDJ74265.1,Q…
+Malonyl-CoA, Malonyl-CoA
Step 15
Start
+N-acetylglucosami…
Step 16
Start
+D-glucose
Step 2
QDJ74267.1,QDJ74285.1
Step 3
QDJ74267.1,QDJ74285.1
Step 4M1
QDJ74273.1
+
Step 5M2
QDJ74273.1
Step 6M3
QDJ74273.1
+(Valine/Isoleucin…
Step 7M4
QDJ74273.1
Step 8M5
QDJ74274.1
Step 9M6
QDJ74275.1
Step 10M7
QDJ74275.1
Step 11M8
QDJ74275.1
Step 12M9
QDJ74275.1
Step 13TE
QDJ74275.1
Step 14
QDJ74279.1
Step 17
QDJ74280.1
Step 18
QDJ74280.1
Step 19
QDJ74280.1
Step 20
QDJ74279.1
Step 21
QDJ74279.1
Step 23
QDJ74279.1
Step 24
QDJ74279.1
Step 25
QDJ74280.1
Step 26
QDJ74280.1
Step 27
QDJ74280.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions26 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12109-1QDJ74266.1,QDJ74265.1,QDJ74264.1,QDJ74263.1,QDJ74262.1,QDJ74259.1,QDJ74258.1,QDJ74257.1,QDJ74256.1—
Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA
C/C=C/C=C/C=C/C=C/C=C/C(O)=O—
22109-2QDJ74267.1,QDJ74285.1—
2109-1
from: 2109-1
OC(/C=C/C=C/C=C\C=C\C=C\C)=O—
32109-3QDJ74267.1,QDJ74285.1—
2109-2
from: 2109-2
OC(/C=C/C1=CC=CC=C1/C=C/C)=O—
42109-4QDJ74273.1M1
2109-3;
from: 2109-3
OC([C@@H]([C@@H](C)O)NC(/C=C/C1=CC=CC=C1/C=C/C)=O)=O—
52109-5QDJ74273.1M2
2109-4
from: 2109-4
OC([C@@H](CC(N)=O)NC([C@@H]([C@@H](C)O)NC(/C=C/C1=CC=CC=C1/C=C/C)=O)=O)=O—
62109-6QDJ74273.1M3
2109-5;(Valine/Isoleucine)
from: 2109-5
OC([C@H](NC([C@@H](CC(N)=O)NC([C@@H]([C@@H](C)O)NC(/C=C/C1=CC=CC=C1/C=C/C)=O)=O)=O)[C@H]([R])C)=O—
72109-7QDJ74273.1M4
2109-6
from: 2109-6
OC([C@H](CC1=CC=CC=C1)N(C([C@H](NC([C@@H](CC(N)=O)NC([C@@H]([C@@H](C)O)NC(/C=C/C2=CC=CC=C2/C=C/C)=O)=O)=O)[C@H]([R])C)=O)C)=O—
82109-8QDJ74274.1M5
2109-7
from: 2109-7
OC([C@H](C(C)C)NC([C@H](CC1=CC=CC=C1)N(C([C@H](NC([C@@H](CC(N)=O)NC([C@@H]([C@@H](C)O)NC(/C=C/C2=CC=CC=C2/C=C/C)=O)=O)=C)[C@H]([R])C)=O)C)=O)=O—
92109-9QDJ74275.1M6
2109-8
from: 2109-8
OC(CNC([C@H](C(C)C)NC([C@H](CC1=CC=CC=C1)N(C([C@H](NC([C@@H](CC(N)=O)NC([C@@H]([C@@H](C)O)NC(/C=C/C2=CC=CC=C2/C=C/C)=O)=O)=O)[C@H]([R])C)=O)C)=O)=O)=O—
102109-10QDJ74275.1M7
2109-9
from: 2109-9
OC(CNC(CNC([C@H](C(C)C)NC([C@H](CC1=CC=CC=C1)N(C([C@H](NC([C@@H](CC(N)=O)NC([C@@H]([C@@H](C)O)NC(/C=C/C2=CC=CC=C2/C=C/C)=O)=O)=C)[C@H]([R])C)=O)C)=O)=O)=O)=O—
112109-11QDJ74275.1M8
2109-10
from: 2109-10
OC([C@H](C(C)C)NC(CNC(CNC([C@H](C(C)C)NC([C@H](CC1=CC=CC=C1)N(C([C@H](NC([C@@H](CC(N)=O)NC([C@@H]([C@@H](C)O)NC(/C=C/C2=CC=CC=C2/C=C/C)=O)=O)=C)[C@H]([R])C)=O)C)=O)=O)=O)=O)=O—
122109-12QDJ74275.1M9
2109-11
from: 2109-11
O=C([C@H](CC(C)C)NC([C@H](C(C)C)NC(CNC(CNC([C@H](C(C)C)NC([C@H](CC1=CC=CC=C1)N(C([C@H](NC([C@@H](CC(N)=O)NC([C@@H]([C@@H](C)O)NC(/C=C/C2=CC=CC=C2/C=C/C)=O)=O)=C)[C@H]([R])C)=O)C)=O)=O)=O)=O)=O)O—
132109-13QDJ74275.1TE
2109-12
from: 2109-12
C/C=C/C1=CC=CC=C1/C=C/C(N[C@@H](C(N[C@H](CC(N)=O)C(N[C@H](C(N([C@@H](CC2=CC=CC=C2)C(N[C@@H](C(NCC(NCC(N[C@@H]3C(C)C)=O)=O)=O)C(C)C)=O)C)=O)[C@@H]([R])C)=O)=O)[C@H](OC([C@H](CC(C)C)NC3=O)=O)C)=O—
142109-14QDJ74279.1—
2109-13
from: 2109-13
O=C(N[C@@H](C(N[C@H](CC(N)=O)C(N[C@H](C(N([C@@H](CC1=CC=CC=C1)C(N[C@@H](C(NCC(NCC(N[C@@H]2C(C)C)=O)=O)=O)C(C)C)=O)C)=O)[C@@H]([R])C)=O)=O)[C@H](OC([C@H](CC(C)C)NC2=O)=O)C)/C=C/C3=CC=CC=C3/C=C/CO—
152109-15Start—
N-acetylglucosamine
O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1—
162109-16Start—
D-glucose
O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1—
172109-17QDJ74280.1—
2109-14;2109-15
from: 2109-14, 2109-15
O=C(N[C@@H](C(N[C@H](CC(N)=O)C(N[C@H](C(N([C@@H](CC1=CC=CC=C1)C(N[C@@H](C(NCC(NCC(N[C@@H]2C(C)C)=O)=O)=O)C(C)C)=O)C)=O)[C@@H]([R])C)=O)=O)[C@H](OC([C@H](CC(C)C)NC2=O)=O)C)/C=C/C3=CC=CC=C3/C=C/C(O[C@H]4[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O4)=O—
182109(1)QDJ74280.1—
2109-14;2109-15
from: 2109-14, 2109-15
O=C(N[C@@H](C(N[C@H](CC(N)=O)C(N[C@H](C(N([C@@H](CC1=CC=CC=C1)C(N[C@@H](C(NCC(NCC(N[C@@H]2C(C)C)=O)=O)=O)C(C)C)=O)C)=O)C(C)C)=O)=O)[C@H](OC([C@H](CC(C)C)NC2=O)=O)C)/C=C/C3=CC=CC=C3/C=C/C(O[C@H]4[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O4)=O—
192109(2)QDJ74280.1—
2109-14;2109-15
from: 2109-14, 2109-15
O=C(N[C@@H](C(N[C@H](CC(N)=O)C(N[C@H](C(N([C@@H](CC1=CC=CC=C1)C(N[C@@H](C(NCC(NCC(N[C@@H]2C(C)C)=O)=O)=O)C(C)C)=O)C)=O)[C@@H](CC)C)=O)=O)[C@H](OC([C@H](CC(C)C)NC2=O)=O)C)/C=C/C3=CC=CC=C3/C=C/C(O[C@H]4[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O4)=O—
202109-18QDJ74279.1—
2109-14
from: 2109-14
O=C(N[C@@H](C(N[C@H](CC(N)=O)C(N[C@H](C(N([C@@H](CC1=CC=CC=C1)C(N[C@@H](C(NCC(NCC(N[C@@H]2C(C)C)=O)=O)=O)C(C)C)=O)C)=O)[C@@H]([R])C)=O)=O)[C@H](OC([C@H](CC(C)C)NC2=O)=O)C)/C=C/C3=CC=CC=C3/C=C/C([H])=O—
212109-19QDJ74279.1—
2109-18
from: 2109-18
O=C(N[C@@H](C(N[C@H](CC(N)=O)C(N[C@H](C(N([C@@H](CC1=CC=CC=C1)C(N[C@@H](C(NCC(NCC(N[C@@H]2C(C)C)=O)=O)=O)C(C)C)=O)C)=O)[C@@H]([R])C)=O)=O)[C@H](OC([C@H](CC(C)C)NC2=O)=O)C)/C=C/C3=CC=CC=C3/C=C/C(O)=O—
232109(3)QDJ74279.1—
2109-18
from: 2109-18
O=C(N[C@@H](C(N[C@H](CC(N)=O)C(N[C@H](C(N([C@@H](CC1=CC=CC=C1)C(N[C@@H](C(NCC(NCC(N[C@@H]2C(C)C)=O)=O)=O)C(C)C)=O)C)=O)C(C)C)=O)=O)[C@H](OC([C@H](CC(C)C)NC2=O)=O)C)/C=C/C3=CC=CC=C3/C=C/C(O)=O—
242109(4)QDJ74279.1—
2109-18
from: 2109-18
O=C(N[C@@H](C(N[C@H](CC(N)=O)C(N[C@H](C(N([C@@H](CC1=CC=CC=C1)C(N[C@@H](C(NCC(NCC(N[C@@H]2C(C)C)=O)=O)=O)C(C)C)=O)C)=O)[C@@H](CC)C)=O)=O)[C@H](OC([C@H](CC(C)C)NC2=O)=O)C)/C=C/C3=CC=CC=C3/C=C/C(O)=O—
252109-20QDJ74280.1—
2109-19;2109-16;2109-16
from: 2109-19, 2109-16, 2109-16
O=C(N[C@@H](C(N[C@H](CC(N)=O)C(N[C@H](C(N([C@@H](CC1=CC=CC=C1)C(N[C@@H](C(NCC(NCC(N[C@@H]2C(C)C)=O)=O)=O)C(C)C)=O)C)=O)[C@@H]([R])C)=O)=O)[C@H](OC([C@H](CC(C)C)NC2=O)=O)C)/C=C/C3=CC=CC=C3/C=C/C(O[C@H]4[C@H](O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)[C@@H](O)[C@H](O)[C@@H](CO)O4)=O—
262109(5)QDJ74280.1—
2109-19;2109-16;2109-16
from: 2109-19, 2109-16, 2109-16
O=C(N[C@@H](C(N[C@H](CC(N)=O)C(N[C@H](C(N([C@@H](CC1=CC=CC=C1)C(N[C@@H](C(NCC(NCC(N[C@@H]2C(C)C)=O)=O)=O)C(C)C)=O)C)=O)C(C)C)=O)=O)[C@H](OC([C@H](CC(C)C)NC2=O)=O)C)/C=C/C3=CC=CC=C3/C=C/C(O[C@H]4[C@H](O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)[C@@H](O)[C@H](O)[C@@H](CO)O4)=O—
272109(6)QDJ74280.1—
2109-19;2109-16;2109-16
from: 2109-19, 2109-16, 2109-16
O=C(N[C@@H](C(N[C@H](CC(N)=O)C(N[C@H](C(N([C@@H](CC1=CC=CC=C1)C(N[C@@H](C(NCC(NCC(N[C@@H]2C(C)C)=O)=O)=O)C(C)C)=O)C)=O)[C@@H](CC)C)=O)=O)[C@H](OC([C@H](CC(C)C)NC2=O)=O)C)/C=C/C3=CC=CC=C3/C=C/C(O[C@H]4[C@H](O[C@H]5[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O5)[C@@H](O)[C@H](O)[C@@H](CO)O4)=O—
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