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BGC0002102PKS

pladienolide B

Producing organism
Streptomyces platensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
12
DOI
MIBiG entry
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pladienolide B

Gene Cluster Map9 genes · 66,051 bp

KSKSKSKSKSKSKSKSKSKSKS10 kb66.0 kb visible · 66,051 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

12 steps · 11 edges
Step 1Load
pldAI
+methylmalonyl-CoA
Step 2M1
pldAI
+methylmalonyl-CoA
Step 3M2
pldAI
+malonyl-CoA
Step 4M3
pldAI
+methylmalonyl-CoA
Step 5M4
pldAII
+malonyl-CoA
Step 6M5
pldAII;pldAIII
+methylmalonyl-CoA
Step 7M6
pldAIII
+methylmalonyl-CoA
Step 8M7
pldAIII
+malonyl-CoA
Step 9M8
pldAIV
+methylmalonyl-CoA
Step 10M9
pldAIV
+malonyl-CoA
Step 11M10
pldAV
+malonyl-CoA
Step 12TE
pldAV, ?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions12 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12102-1pldAILoading
methylmalonyl-CoA
OC(CC)=O—
22102-2pldAIM1
2102-1;methylmalonyl-CoA
from: 2102-1
OC([C@H](C)[C@@H](O)CC)=O—
32102-3pldAIM2
2102-2;malonyl-CoA
from: 2102-2
OC(/C=C/[C@H](C)[C@@H](O)CC)=O—
42102-4pldAIM3
2102-3;methylmalonyl-CoA
from: 2102-3
OC([C@@H](C)C/C=C/[C@H](C)[C@@H](O)CC)=O—
52102-5pldAIIM4
2102-4;malonyl-CoA
from: 2102-4
OC(/C=C/[C@@H](C)C/C=C/[C@H](C)[C@@H](O)CC)=O—
62102-6pldAII;pldAIIIM5
2102-5;methylmalonyl-CoA
from: 2102-5
OC(/C(C)=C/C=C/[C@@H](C)C/C=C/[C@H](C)[C@@H](O)CC)=O—
72102-7pldAIIIM6
2102-6;methylmalonyl-CoA
from: 2102-6
OC([C@H](C)[C@H](O)/C(C)=C/C=C/[C@@H](C)C/C=C/[C@H](C)[C@@H](O)CC)=O—
82102-8pldAIIIM7
2102-7;malonyl-CoA
from: 2102-7
OC(/C=C/[C@H](C)[C@H](O)/C(C)=C/C=C/[C@@H](C)C/C=C/[C@H](C)[C@@H](O)CC)=O—
92102-9pldAIVM8
2102-8;methylmalonyl-CoA
from: 2102-8
OC([C@H](C)[C@H](O)/C=C/[C@H](C)[C@H](O)/C(C)=C/C=C/[C@@H](C)C/C=C/[C@H](C)[C@@H](O)CC)=O—
102102-10pldAIVM9
2102-9;malonyl-CoA
from: 2102-9
OC(CC[C@H](C)[C@H](O)/C=C/[C@H](C)[C@H](O)/C(C)=C/C=C/[C@@H](C)C/C=C/[C@H](C)[C@@H](O)CC)=O—
112102-11pldAVM10
2102-10;malonyl-CoA
from: 2102-10
O=C(C[C@H](O)CC[C@H](C)[C@H](O)/C=C/[C@H](C)[C@H](O)/C(C)=C/C=C/[C@@H](C)C/C=C/[C@H](C)[C@@H](O)CC)O—
122102pldAV, ?TE
2102-11
from: 2102-11
C[C@@H]([C@@H](O1)[C@H]1C[C@@H](/C=C/C=C([C@H]([C@@H](C)/C=C/[C@H](OC(C)=O)[C@@](O)(C)CC[C@@H](O)C2)OC2=O)\C)C)[C@@H](O)CC—
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