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BGC0002100NRPS

colibrimycin

Producing organism
Streptomyces sp. CS147
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type 1);other (other)
Total steps
5
DOI
MIBiG entry
View on MIBiG ↗
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colibrimycin
C27H28ClN5O7569.17 Da

Gene Cluster Map52 genes · 68,892 bp

AKSAA10 kb68.9 kb visible · 68,892 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
EEpimerization (E)
MTMethyltransferase
AmTAminotransferase I/II
TauDTauD oxygenase
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

5 steps · 4 edges
Step 1
DBP21_21635,DBP21_21640…
+malonyl-CoA, malonyl-CoA
Step 2M1
DBP21_21655,?
+diaminopropionic …
Step 3M2
DBP21_21655,?
+chlorinated trypt…
Step 4M3
DBP21_21655
+aspartic acid
Step 5TE
DBP21_21655
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions5 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12100-1DBP21_21635,DBP21_21640,DBP21_21645—
malonyl-CoA;malonyl-CoA;malonyl-CoA
OC(/C=C\C=C\C=C\C)=O—
22100-2DBP21_21655,?M1
2100-1;diaminopropionic acid
from: 2100-1
OC(C(CN)NC(/C=C\C=C\C=C\C)=O)=O—
32100-3DBP21_21655,?M2
2100-2;chlorinated tryptophan
from: 2100-2
OC(/C(NC(C(CN)NC(/C=C\C=C\C=C\C)=O)=O)=C/C1=CNC2=C1C=CC(Cl)=C2)=O—
42100-4DBP21_21655M3
2100-3;aspartic acid
from: 2100-3
OC(C(NC(/C(NC(C(CN)NC(/C=C\C=C\C=C\C)=O)=O)=C/C1=CNC2=C1C=CC(Cl)=C2)=O)C(C(O)=O)OC)=O—
52100DBP21_21655TE
2100-4
from: 2100-4
OC(C(NC(/C(NC(C(CN)NC(/C=C\C=C\C=C\C)=O)=O)=C/C1=CNC2=C1C=CC(Cl)=C2)=O)C(C(O)=O)OC)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture