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BGC0002098PKS

ECO-0501

Producing organism
Amycolatopsis keratiniphila
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Amycolatopsis›Amycolatopsis japonica group
Biosynthetic class
PKS (Unknown)
Total steps
22
DOI
MIBiG entry
View on MIBiG ↗
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ECO-0501

Gene Cluster Map41 genes · 101,044 bp

20 kb101.0 kb visible · 101,044 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

22 steps · 22 edges
Step 1
Start
+Arginine
Step 16
Start
+D-glucose
Step 18
AORI_2943
+Glycine, succinyl-CoA
Step 2
AORI_2934
Step 17
AORI_2940
Step 19
AORI_2944
Step 3Load
AORI_2932;AORI_2951;AOR…
Step 20
?
Step 4M1
AORI_2945
+malonyl-CoA
Step 5M2
AORI_2945
+methylmalonyl-CoA
Step 6M3
AORI_2946
+malonyl-CoA
Step 7M4
AORI_2946
+malonyl-CoA
Step 8M5
AORI_2946
+methylmalonyl-CoA
Step 9M6
AORI_2947
+methylmalonyl-CoA
Step 10M7
AORI_2948
+methylmalonyl-CoA
Step 11M8
AORI_2948
+malonyl-CoA
Step 12M9
AORI_2949
+malonyl-CoA
Step 13M10
AORI_2949
+malonyl-CoA
Step 14M11
AORI_2949
+malonyl-CoA
Step 15M12
AORI_2950
+methylmalonyl-CoA
Step
AORI_2941;AORI_2942
Step 21
AORI_2941,AORI_2942
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions22 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12098-1Start—
Arginine
N=C(NCCCC(N)C(O)=O)N—
22098-2AORI_2934—
2098-1
from: 2098-1
N=C(NCCCC([R])=O)N—
32098-3AORI_2932;AORI_2951;AORI_2952Loading
2098-2
from: 2098-2
N=C(N(C)CCCC(O)=O)N—
42098-4AORI_2945M1
2098-3;malonyl-CoA
from: 2098-3
N=C(N(C)CCCCCC(O)=O)N—
52098-5AORI_2945M2
2098-4;methylmalonyl-CoA
from: 2098-4
N=C(N(C)CCC/C=C/CC(C)C(O)=O)N—
62098-6AORI_2946M3
2098-5;malonyl-CoA
from: 2098-5
N=C(N(C)CCC/C=C/CC(C)/C=C/C(O)=O)N—
72098-7AORI_2946M4
2098-6;malonyl-CoA
from: 2098-6
N=C(N(C)CCC/C=C/CC(C)/C=C/CCC(O)=O)N—
82098-8AORI_2946M5
2098-7;methylmalonyl-CoA
from: 2098-7
N=C(N(C)CCC/C=C/CC(C)/C=C/CCCC(C(O)=O)C)N—
92098-9AORI_2947M6
2098-8;methylmalonyl-CoA
from: 2098-8
N=C(N(C)CCC/C=C/CC(C)/C=C/CCCC(/C=C(C(O)=O)\C)C)N—
102098-10AORI_2948M7
2098-9;methylmalonyl-CoA
from: 2098-9
N=C(N(C)CCC/C=C/CC(C)/C=C/CCCC(/C=C(C(O)C(C(O)=O)C)\C)C)N—
112098-11AORI_2948M8
2098-10;malonyl-CoA
from: 2098-10
N=C(N(C)CCC/C=C/CC(C)/C=C/CCCC(/C=C(C(O)C(/C=C/C(O)=O)C)\C)C)N—
122098-12AORI_2949M9
2098-11;malonyl-CoA
from: 2098-11
N=C(N(C)CCC/C=C/CC(C)/C=C/CCCC(/C=C(C(O)C(/C=C/C=C/C(O)=O)C)\C)C)N—
132098-13AORI_2949M10
2098-12;malonyl-CoA
from: 2098-12
N=C(N(C)CCC/C=C/CC(C)/C=C/CCCC(/C=C(C(O)C(/C=C/C=C/C=C/C(O)=O)C)\C)C)N—
142098-14AORI_2949M11
2098-13;malonyl-CoA
from: 2098-13
N=C(N(C)CCC/C=C/CC(C)/C=C/CCCC(/C=C(C(O)C(/C=C/C=C/C=C/C=C/C(O)=O)C)\C)C)N—
152098-15AORI_2950M12
2098-14;methylmalonyl-CoA
from: 2098-14
N=C(N(C)CCC/C=C/CC(C)/C=C/CCCC(/C=C(C(O)C(/C=C/C=C/C=C/C=C/C=C(C(O)=O)\C)C)\C)C)N—
162098-16Start—
D-glucose
OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O—
172098-17AORI_2940—
2098-16
from: 2098-16
OC([C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O)=O—
182098-18AORI_2943—
Glycine;succinyl-CoA
O=C(O)CCC(CN)=O—
192098-19AORI_2944—
2098-18
from: 2098-18
O=C([R])CCC(CN)=O—
202098-20?—
2098-19
from: 2098-19
OC(CC1)=C(N)C1=O—
212098AORI_2941,AORI_2942—
2098-15;2098-17;2098-20
from: 2098-15, 2098-17, 2098-20
OC([C@H]1O[C@@H](O[C@H](C(/C=C/C=C/C=C/C=C/C=C(C(NC2=C(O)CCC2=O)=O)\C)C)/C(C)=C/C(C)CCC/C=C/C(C)C/C=C/CCCN(C)C(N)=N)[C@H](O)[C@@H](O)[C@@H]1O)=O—
2098AORI_2941;AORI_2942—
2098-14;2098-15;2098-16
from: 2098-14, 2098-15, 2098-16
OC([C@H]1O[C@@H](O[C@H](C(/C=C/C=C/C=C/C=C/C=C(C(NC2=C(O)CCC2=O)=O)\C)C)/C(C)=C/C(C)CCC/C=C/C(C)C/C=C/CCCNC(N)=N)[C@H](O)[C@@H](O)[C@@H]1O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture