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BGC0002095NRPS

leupeptin Pr;leupeptin Ac

Producing organism
Streptomyces roseus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type 1)
Total steps
8
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map8 genes · 22,455 bp

CACATEETgrCAA5 kb22.5 kb visible · 22,455 bp total
Biosynthetic (core)
Biosynthetic (additional)
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
CcCOM C-term
TEThioesterase (TE)
EEpimerization (E)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

8 steps · 6 edges
Step 1
?
+Leucine, acetyl-CoA
Step 5
?
+Leucine, propionyl-CoA
Step 2
?
+Leucine
Step 6
?
+Leucine
Step 3
?
+Arginine
Step 7
?
+Arginine
Step 4
?
Step 8
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions8 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12095-1?—
Leucine;acetyl-CoA
O=C(C)NC(C(N)=O)CC(C)C—
22095-2?—
2095-1;Leucine
from: 2095-1
O=C(C)NC(C(NC(C(N)=O)CC(C)C)=O)CC(C)C—
32095-3?—
2095-2;Arginine
from: 2095-2
O=C(C)NC(C(NC(C(NC(C(O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(C)C—
42095(1)?—
2095-3
from: 2095-3
O=C(C)NC(C(NC(C(NC(C=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(C)C—
52095-4?—
Leucine;propionyl-CoA
O=C(CC)NC(C(N)=O)CC(C)C—
62095-5?—
2095-4;Leucine
from: 2095-4
O=C(CC)NC(C(NC(C(N)=O)CC(C)C)=O)CC(C)C—
72095-6?—
2095-5;Arginine
from: 2095-5
O=C(CC)NC(C(NC(C(NC(C(O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(C)C—
82095(2)?—
2095-6
from: 2095-6
O=C(CC)NC(C(NC(C(NC(C=O)CCCNC(N)=N)=O)CC(C)C)=O)CC(C)C—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture