NPdia
← Back to Repository
BGC0002090Hybrid

undecylprodigiosin;metacycloprodigiosin

Producing organism
Streptomyces griseoaurantiacus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces aurantiacus group
Biosynthetic class
PKS (Type 1);NRPS (Type 1)
Total steps
14
DOI
MIBiG entry
View on MIBiG ↗
Loading…

Gene Cluster Map23 genes · 36,310 bp

KSKSKSAmTACALKSATAmTNADTE5 kb36.3 kb visible · 36,310 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
MTMethyltransferase
CALCoA-ligase (CAL)
AmTAminotransferase I/II
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

14 steps · 13 edges
Step 1
H1X69_07235;H1X69_07225
+Proline
Step 8
(H1X69_07210,H1X69_0722…
+acetyl-CoA, malonyl-CoA
Step 13
?
+wasserman pyrrole
Step 2
H1X69_07175
Step 9
H1X69_07240
+malonyl-CoA
Step 3
H1X69_07170
Step 10
H1X69_07240
+Glycine
Step 4
H1X69_07230
+malonyl-CoA
Step 11
H1X69_07245
Step 5
H1X69_07230
+Serine
Step 6
H1X69_07190
Step 7
H1X69_07255, ?
Step 12
H1X69_07260
Step 14
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions14 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12090-1H1X69_07235;H1X69_07225—
Proline
O=C(C1NCCC1)O—
22090-2H1X69_07175—
2090-1
from: 2090-1
O=C(C1=CC=CN1)O—
32090-3H1X69_07170—
2090-2
from: 2090-2
O=C(C1=CC=CN1)O—
42090-4H1X69_07230—
2090-3;malonyl-CoA
from: 2090-3
O=C(C1=CC=CN1)CC(O)=O—
52090-5H1X69_07230—
2090-4;Serine
from: 2090-4
OC1=C(CO)NC(C2=CC=CN2)=C1—
62090-6H1X69_07190—
2090-5
from: 2090-5
OC1=C(C=O)NC(C2=CC=CN2)=C1—
72090-7H1X69_07255, ?—
2090-6
from: 2090-6
O=CC1=C(OC)C=C(N1)C2=CC=CN2—
82090-8(H1X69_07210,H1X69_07220);H1X69_07215—
acetyl-CoA;malonyl-CoA;malonyl-CoA;malonyl-CoA;malonyl-CoA;malonyl-CoA
O=C(O)CCCCCCCCCCC—
92090-9H1X69_07240—
2090-8;malonyl-CoA
from: 2090-8
O=C(CC(O)=O)CCCCCCCCCCC—
102090-10H1X69_07240—
2090-9;Glycine
from: 2090-9
O=C1C=C(CCCCCCCCCCC)NC1—
112090-11H1X69_07245—
2090-10
from: 2090-10
CCCCCCCCCCCC1=CC=CN1—
122090(1)H1X69_07260—
2090-7;2090-11
from: 2090-7, 2090-11
CCCCCCCCCCCC(C=C/1)=NC1=C/C2=C(OC)C=C(N2)C3=CC=CN3—
132090-12?—
wasserman pyrrole
CC[C@H]1C2=C([H])NC(CCCCCCCC1)=C2—
142090(2)?—
2090-7;2090-12
from: 2090-7, 2090-12
CC[C@H]1C2=C(/C=C3N=C(C=C\3OC)C4=CC=CN4)NC(CCCCCCCC1)=C2—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture