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BGC0002089NRPS

thaxtomin A;thaxtomin B;thaxtomin C;thaxtomin D

Producing organism
Streptomyces scabiei 87.22
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type 1)
Total steps
8
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map12 genes · 18,465 bp

AMTCAMTC5 kb18.5 kb visible · 18,465 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

8 steps · 7 edges
Step 1
start
+L-Tryptophan
Step 2
SCAB_31831,SCAB_31841
+L-Arginine
Step 3
SCAB_31791,SCAB_31781
+L-Phenylalanine
Step 4
SCAB_31791,SCAB_31781
+L-Phenylalanine
Step 5
SCAB_31791,SCAB_31781
+L-Phenylalanine
Step 6
SCAB_31761
Step 7
SCAB_31761
Step 8
SCAB_31761
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions8 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12089-1start—
L-Tryptophan
N[C@H](C(O)=O)CC1=CNC2=CC=CC=C21—
22089-2SCAB_31831,SCAB_31841—
2089-1;L-Arginine
from: 2089-1
[R]N[C@H](C(O)=O)CC1=CNC2=CC=CC([N+]([O-])=O)=C21—
32089-3SCAB_31791,SCAB_31781—
2089-2;L-Phenylalanine
from: 2089-2
O=C([C@](N1C)([H])CC2=CNC3=CC=CC([N+]([O-])=O)=C32)N([R])C(CC4=CC=CC=C4)C1=O—
42089(1)SCAB_31791,SCAB_31781—
2089-2;L-Phenylalanine
from: 2089-2
O=C([C@](N1C)([H])CC2=CNC3=CC=CC([N+]([O-])=O)=C32)NC(CC4=CC=CC=C4)C1=O—
52089(2)SCAB_31791,SCAB_31781—
2089-2;L-Phenylalanine
from: 2089-2
O=C([C@](N1C)([H])CC2=CNC3=CC=CC([N+]([O-])=O)=C32)N(C)C(CC4=CC=CC=C4)C1=O—
62089-4SCAB_31761—
2089-3
from: 2089-3
O=C([C@](N1C)([H])CC2=CNC3=CC=CC([N+]([O-])=O)=C32)N(C)[C@](CC4=CC=CC([R])=C4)(O)C1=O—
72089(5)SCAB_31761—
2089-3
from: 2089-3
O=C([C@](N1C)([H])CC2=CNC3=CC=CC([N+]([O-])=O)=C32)N(C)[C@](CC4=CC=CC=C4)(O)C1=O—
82089(6)SCAB_31761—
2089-3
from: 2089-3
O=C([C@](N1C)([H])CC2=CNC3=CC=CC([N+]([O-])=O)=C32)N(C)[C@](CC4=CC=CC(O)=C4)(O)C1=O—
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