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BGC0002086PKS

rosamicin

Producing organism
Micromonospora carbonacea
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Micromonospora
Biosynthetic class
PKS (Unknown)
Total steps
11
DOI
MIBiG entry
View on MIBiG ↗
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rosamicin

Gene Cluster Map19 genes · 60,202 bp

KSATKSATKSATKSATKSATKSATERKSATKSATER10 kb60.2 kb visible · 60,202 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Resistance
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

11 steps · 10 edges
Step 1M1
HXZ27_06120
+malonyl-CoA
Step 10
Start
+D-Desosamine
Step 2M2
HXZ27_06120
+methylmalonyl-CoA
Step 3M3
HXZ27_06120
+methylmalonyl-CoA
Step 4M4
HXZ27_06125
+malonyl-CoA
Step 5M5
HXZ27_06130
+methylmalonyl-CoA
Inactive: KR
Step 6M6
HXZ27_06130
+ethylmalonyl-CoA
Step 7M7
HXZ27_06135
+methylmalonyl-CoA
Step 8M8
HXZ27_06140
+malonyl-CoA
Step 9TE
HXZ27_06140
Step 11
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12086-1HXZ27_06120M1
malonyl-CoA
OC(CC)=O—
22086-2HXZ27_06120M2
2086-1;methylmalonyl-CoA
from: 2086-1
OC([C@H](C)[C@H](O)CC)=O—
32086-3HXZ27_06120M3
2086-2;methylmalonyl-CoA
from: 2086-2
OC(/C(C)=C/[C@H](C)[C@H](O)CC)=O—
42086-4HXZ27_06125M4
2086-3;malonyl-CoA
from: 2086-3
OC(/C=C/C(C)=C/[C@H](C)[C@H](O)CC)=O—
52086-5HXZ27_06130M5
2086-4;methylmalonyl-CoA
from: 2086-4
OC([C@H](C(/C=C/C(C)=C/[C@H](C)[C@H](O)CC)=O)C)=O{'Inactive':['KR']}
62086-6HXZ27_06130M6
2086-5;ethylmalonyl-CoA
from: 2086-5
OC([C@@H](CC)C[C@H](C(/C=C/C(C)=C/[C@H](C)[C@H](O)CC)=O)C)=O—
72086-7HXZ27_06135M7
2086-6;methylmalonyl-CoA
from: 2086-6
OC([C@H](C)[C@@H](O)[C@@H](CC)C[C@H](C(/C=C/C(C)=C/[C@H](C)[C@H](O)CC)=O)C)=O—
82086-8HXZ27_06140M8
2086-7;malonyl-CoA
from: 2086-7
O=C(O)C[C@@H](O)[C@H](C)[C@@H](O)[C@@H](CC)C[C@H](C(/C=C/C(C)=C/[C@H](C)[C@H](O)CC)=O)C—
92086-9HXZ27_06140TE
2086-8
from: 2086-8
O=C(C[C@H]1O)O[C@H](CC)[C@@H](C)/C=C(C)/C=C/C([C@H](C)C[C@H](CC)[C@H](O)[C@H]1C)=O—
102086-10Start—
D-Desosamine
O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O—
112086?—
2086-9;2086-10
from: 2086-9, 2086-10
O=C(C[C@H]1O)O[C@H](CC)[C@@H](C)[C@]([H])(O2)C2(C)/C=C/C([C@H](C)C[C@H](CC=O)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C)[C@H]3O)[C@H]1C)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture