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BGC0002072PKS

linearmycin A;linearmycin B;linearmycin C

Producing organism
Streptomyces sp. Mg1
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type 1)
Total steps
37
DOI
MIBiG entry
View on MIBiG ↗
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Gene Cluster Map27 genes · 175,472 bp

50 kb175.5 kb visible · 175,472 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
ACPSACP synthase

Pathway Graphsteps arranged in biosynthetic order

37 steps · 36 edges
Step 1
start
+aminobutanoic aci…
Step 2M1
M444_04850
+malonyl-CoA
Step 3M2
M444_04850
+malonyl-CoA
Step 4M3
M444_04850
+malonyl-CoA
Step 5M4
M444_04850
+malonyl-CoA
Step 6M5
M444_04850
+malonyl-CoA
Step 7M6
M444_04850
+malonyl-CoA
Step 8M7
M444_04850
+malonyl-CoA
Step 9M8
M444_04845
+malonyl-CoA
Inactive: DH
Step 10M9
M444_04845
+malonyl-CoA
Step 11M10
M444_04840
+malonyl-CoA
Step 12M11
M444_04840
+malonyl-CoA
Step 13M12
M444_04840
+malonyl-CoA
Step 14M13
M444_04840
+malonyl-CoA
Step 15M14
M444_04835
+methylmalonyl-CoA
Inactive: KR
Step 16M15
M444_04830
+malonyl-CoA
Step 17M16
M444_04830
+malonyl-CoA
Step 18M17
M444_04830
+malonyl-CoA
Step 19M18
M444_04825
+malonyl-CoA
Step 20M19
M444_04825
+malonyl-CoA
Step 21M20
M444_04825
+malonyl-CoA
Step 22M21
M444_04820
+methylmalonyl-CoA
Step 23M22
M444_04820
+methylmalonyl-CoA
Step 24M23
M444_04815
+malonyl-CoA
Step 25M24
M444_04815
+malonyl-CoA
Step 26M25
M444_04815
+malonyl-CoA
Step 27M26
M444_04815
+malonyl-CoA
Step 28M27/28
M444_04810
+malonyl-CoA
Module Skip
Step 29M29
M444_04810
+methylmalonyl-CoA
Step 30TE
M444_04810
Step 31TE
M444_04810
Step 32M27
M444_04810
+malonyl-CoA
Step 33M28
M444_04810
+malonyl-CoA
Step 34M29
M444_04810
+methylmalonyl-CoA
Step 35TE
M444_04810
Step 36TE
M444_04810
Step 37TE
M444_04810
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions37 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12072-1start—
aminobutanoic acid/aminovaleric acid
O=C(O)CCC[R]—
22072-2M444_04850M1
2072-1;malonyl-CoA
from: 2072-1
OC(CC(O)=O)CCC[R]—
32072-3M444_04850M2
2072-2;malonyl-CoA
from: 2072-2
OC(CC(O)CC(O)=O)CCC[R]—
42072-4M444_04850M3
2072-3;malonyl-CoA
from: 2072-3
OC(CC(O)C/C=C/C(O)=O)CCC[R]—
52072-5M444_04850M4
2072-4;malonyl-CoA
from: 2072-4
OC(CC(O)C/C=C/C(O)CC(O)=O)CCC[R]—
62072-6M444_04850M5
2072-5;malonyl-CoA
from: 2072-5
OC(CC(O)C/C=C/C(O)C/C=C/C(O)=O)CCC[R]—
72072-7M444_04850M6
2072-6;malonyl-CoA
from: 2072-6
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)=O)O)CCC[R]—
82072-8M444_04850M7
2072-7;malonyl-CoA
from: 2072-7
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)=O)O)CCC[R]—
92072-9M444_04845M8
2072-8;malonyl-CoA
from: 2072-8
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)=O)O)CCC[R]{'Inactive':['DH']}
102072-10M444_04845M9
2072-9;malonyl-CoA
from: 2072-9
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)CC(O)=O)O)CCC[R]—
112072-11M444_04840M10
2072-10;malonyl-CoA
from: 2072-10
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)=O)O)CCC[R]—
122072-12M444_04840M11
2072-11;malonyl-CoA
from: 2072-11
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)=O)O)CCC[R]—
132072-13M444_04840M12
2072-12;malonyl-CoA
from: 2072-12
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)=O)O)CCC[R]—
142072-14M444_04840M13
2072-13;malonyl-CoA
from: 2072-13
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(O)=O)O)CCC[R]—
152072-15M444_04835M14
2072-14;methylmalonyl-CoA
from: 2072-14
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)=O)=O)O)CCC[R]{'Inactive':['KR']}
162072-16M444_04830M15
2072-15;malonyl-CoA
from: 2072-15
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)CC(O)=O)=O)O)CCC[R]—
172072-17M444_04830M16
2072-16;malonyl-CoA
from: 2072-16
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C(O)=O)=O)O)CCC[R]—
182072-18M444_04830M17
2072-17;malonyl-CoA
from: 2072-17
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C(O)=O)=O)O)CCC[R]—
192072-19M444_04825M18
2072-18;malonyl-CoA
from: 2072-18
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C(O)=O)=O)O)CCC[R]—
202072-20M444_04825M19
2072-19;malonyl-CoA
from: 2072-19
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C(O)=O)=O)O)CCC[R]—
212072-21M444_04825M20
2072-20;malonyl-CoA
from: 2072-20
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)=O)=O)O)CCC[R]—
222072-22M444_04820M21
2072-21;methylmalonyl-CoA
from: 2072-21
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)=O)=O)O)CCC[R]—
232072-23M444_04820M22
2072-22;methylmalonyl-CoA
from: 2072-22
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)C(O)=O)=O)O)CCC[R]—
242072-24M444_04815M23
2072-23;malonyl-CoA
from: 2072-23
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/C(O)=O)=O)O)CCC[R]—
252072-25M444_04815M24
2072-24;malonyl-CoA
from: 2072-24
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CCC(O)=O)=O)O)CCC[R]—
262072-26M444_04815M25
2072-25;malonyl-CoA
from: 2072-25
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CC/C=C/C(O)=O)=O)O)CCC[R]—
272072-27M444_04815M26
2072-26;malonyl-CoA
from: 2072-26
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CC/C=C/C=C/C(O)=O)=O)O)CCC[R]—
282072-28M444_04810M27/28
2072-27;malonyl-CoA
from: 2072-27
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CC/C=C/C=C/C=C/C(O)=O)=O)O)CCC[R]{'ModuleSkip': 'Skip', ('M44…
292072-29M444_04810M29
2072-28;methylmalonyl-CoA
from: 2072-28
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CC/C=C/C=C/C=C/C=C(C)/C(O)=O)=O)O)CCC[R]—
302072-30M444_04810TE
2072-29
from: 2072-29
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CC/C=C/C=C/C=C/C=C(C)/C(O)=O)=O)O)CCC[R]—
312072(1)M444_04810TE
2072-29
from: 2072-29
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CC/C=C/C=C/C=C/C=C(C)/C(O)=O)=O)O)CCCN—
322072-30M444_04810M27
2072-27;malonyl-CoA
from: 2072-27
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CC/C=C/C=C/C=C/C(O)=O)=O)O)CCC[R]—
332072-31M444_04810M28
2072-30;malonyl-CoA
from: 2072-30
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CC/C=C/C=C/C=C/C=C/C(O)=O)=O)O)CCC[R]—
342072-32M444_04810M29
2072-31;methylmalonyl-CoA
from: 2072-31
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CC/C=C/C=C/C=C/C=C/C=C(C)/C(O)=O)=O)O)CCC[R]—
352072-33M444_04810TE
2072-32
from: 2072-32
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CC/C=C/C=C/C=C/C=C/C=C(C)/C(O)=O)=O)O)CCC[R]—
362072(2)M444_04810TE
2072-32
from: 2072-32
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CC/C=C/C=C/C=C/C=C/C=C(C)/C(O)=O)=O)O)CCCN—
372072(3)M444_04810TE
2072-32
from: 2072-32
OC(CC(O)C/C=C/C(O)C/C=C/C(CC(O)CC(O)CC(O)C/C=C/C(O)CC(O)CC(O)CC(C(C)C(O)C/C=C/C=C/C=C/C=C/C=C/C(O)C(C)C(O)C(C)/C=C/CC/C=C/C=C/C=C/C=C/C=C(C)/C(O)=O)=O)O)CCCCN—
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