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BGC0002054Hybrid

amipurimycin

Producing organism
Streptomyces novoguineensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown);NRPS (Type 1);saccharide (None)
Total steps
14
DOI
MIBiG entry
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amipurimycin
C20H29N7O8496.00 Da

Gene Cluster Map30 genes · 57,776 bp

AAmTKSATA10 kb57.8 kb visible · 57,776 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
KRKetoreductase (KR)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
AmTAminotransferase III
AmTAminotransferase IV

Pathway Graphsteps arranged in biosynthetic order

14 steps · 13 edges
Step 1
?
+a-ketoglutarate
Step 8
start
+1,3-biphosphoglyc…
Step 2
apmA1
Step 9
apmB1;apmB3
Step 3
apmA3
+Malonyl-CoA
Step 10
apmB4
Step 4
apmA2?
Step 11
apmB2
Step 5
apmA4
Step 12
apmB5,apmC1,apmC2,apmG,…
+Ketose phosphate
Step 13
?
+Guanosine
Step 6
apmA5,apmA6
Step 7
?
Step 14
apmA8
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions14 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12054-1?—
a-ketoglutarate
O=CCCC(O)=O—
22054-2apmA1—
2054-1
from: 2054-1
O=CCCC([R])=O—
32054-3apmA3—
2054-2;Malonyl-CoA
from: 2054-2
OC(CC(CCC=O)=O)=O—
42054-4apmA2?—
2054-3
from: 2054-3
O=C(O)C1C(CCC1O)=O—
52054-5apmA4—
2054-4
from: 2054-4
O=C(O)C1=CCCC1=O—
62054-6apmA5,apmA6—
2054-5
from: 2054-5
O=C(O)C1=CCC[C@@H]1N—
72054-7?—
2054-6
from: 2054-6
O=C(O)C1[C@@H](N)CCC1—
82054-8start—
1,3-biphosphoglycerate
O[C@H](COP([O-])([O-])=O)C(OP([O-])([O-])=O)=O—
92054-9apmB1;apmB3—
2054-8
from: 2054-8
O=C(O)C(O)CO—
102054-10apmB4—
2054-9
from: 2054-9
O=C(O)C(O)C=O—
112054-11apmB2—
2054-10
from: 2054-10
O=C(O)C(O)C(O)=O—
122054-12apmB5,apmC1,apmC2,apmG,apmH,apmJ,?—
2054-11;Ketose phosphate
from: 2054-11
O=C(O)[C@@H](N)[C@H]1O[C@@H](OP([O-])([O-])=O)[C@H](O)[C@@](O)([C@@H](O)CO)C1—
132054-13?—
2054-11;Guanosine
from: 2054-11
O=C(O)[C@@H](N)[C@H]1O[C@@H](N2C(N=C(N)N=C3)=C3N=C2)[C@H](O)[C@@](O)([C@@H](O)CO)C1—
142054-14apmA8—
2054-13;2054-7
from: 2054-13, 2054-7
O=C(O)[C@@H](NC([C@H]1[C@@H](N)CCC1)=O)[C@H]2O[C@@H](N3C(N=C(N)N=C4)=C4N=C3)[C@H](O)[C@@](O)([C@@H](O)CO)C2—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture