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BGC0002038PKS

nigericin

Producing organism
Streptomyces sp. DASNCL29
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗
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nigericin

Gene Cluster Map30 genes · 95,046 bp

20 kb95.0 kb visible · 95,046 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
DnDocking N-term
DcDocking C-term
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1Load
FGK60_03865
+Malonyl-CoA
Step 2M1
FGK60_03865
+Methylmalonyl-CoA
Inactive: DH
Step 3M2
FGK60_03860
+Methylmalonyl-CoA
Step 4M3
FGK60_03855
+Malonyl-CoA
Step 5M4
FGK60_03855
+Methylmalonyl-CoA
Step 6M5
FGK60_03850
+Methylmalonyl-CoA
Step 7M6
FGK60_03850
+Malonyl-CoA
Step 8M7
FGK60_03845
+Methylmalonyl-CoA
Step 9M8
FGK60_03845
+Methylmalonyl-CoA
Step 10M9
FGK60_03840
+Methylmalonyl-CoA
Inactive: KR
Step 11M10
FGK60_03730;FGK60_03740…
+Methylmalonyl-CoA
Step 12M11
FGK60_03740;FGK60_03745…
+Malonyl-CoA
Step 13M12
FGK60_03765;FGK60_03775…
+Malonyl-CoA
Step 14M13
FGK60_03785
+Methylmalonyl-CoA
Step 15M14
FGK60_03790
+Methylmalonyl-CoA
Inactive: DH
Step 16
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12038-1FGK60_03865Loading
Malonyl-CoA
O=C(O)C—
22038-2FGK60_03865M1
2038-1;Methylmalonyl-CoA
from: 2038-1
O=C([C@H](C)C(O)=O)C{'Inactive':['DH']}
32038-3FGK60_03860M2
2038-2;Methylmalonyl-CoA
from: 2038-2
O=C([C@H](C)C[C@H](C)C(O)=O)C—
42038-4FGK60_03855M3
2038-3;Malonyl-CoA
from: 2038-3
O=C([C@H](C)C[C@H](C)/C=C/C(O)=O)C—
52038-5FGK60_03855M4
2038-4;Methylmalonyl-CoA
from: 2038-4
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)C(O)=O)C—
62038-6FGK60_03850M5
2038-5;Methylmalonyl-CoA
from: 2038-5
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(C)/C(O)=O)C—
72038-7FGK60_03850M6
2038-6;Malonyl-CoA
from: 2038-6
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(C)/CCC(O)=O)C—
82038-8FGK60_03845M7
2038-7;Methylmalonyl-CoA
from: 2038-7
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(C)/CC/C=C(C)/C(O)=O)C—
92038-9FGK60_03845M8
2038-8;Methylmalonyl-CoA
from: 2038-8
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(C)/CC/C=C(C)/CC(C)C(O)=O)C—
102038-10FGK60_03840M9
2038-9;Methylmalonyl-CoA
from: 2038-9
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(C)/CC/C=C(C)/CC(C)C(C(C)C(O)=O)=O)C{'Inactive':['KR']}
112038-11FGK60_03730;FGK60_03740;?M10
2038-10;Methylmalonyl-CoA
from: 2038-10
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(C)/CC/C=C(C)/CC(C)C(C(C)[C@H](O)[C@@H](C)C(O)=O)=O)C—
122038-12FGK60_03740;FGK60_03745;FGK60_03760;?M11
2038-11;Malonyl-CoA
from: 2038-11
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(C)/CC/C=C(C)/CC(C)C(C(C)[C@H](O)[C@@H](C)[C@H](O)CC(O)=O)=O)C—
132038-13FGK60_03765;FGK60_03775;FGK60_03780;?M12
2038-12;Malonyl-CoA
from: 2038-12
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(C)/CC/C=C(C)/CC(C)C(C(C)[C@H](O)[C@@H](C)[C@H](O)CC(O)CC(O)=O)=O)C—
142038-14FGK60_03785M13
2038-13;Methylmalonyl-CoA
from: 2038-13
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(C)/CC/C=C(C)/CC(C)C(C(C)[C@H](O)[C@@H](C)[C@H](O)CC(O)CCC(C)C(O)=O)=O)C—
152038-15FGK60_03790M14
2038-14;Methylmalonyl-CoA
from: 2038-14
O=C([C@H](C)C[C@H](C)/C=C/C[C@H](C)/C=C(C)/CC/C=C(C)/CC(C)C(C(C)[C@H](O)[C@@H](C)[C@H](O)CC(O)CCC(C)C(O)C(C)C(O)=O)=O)C{'Inactive':['DH']}
162038?—
2038-15
from: 2038-15
C[C@](C[C@H]1C)([C@@H]2O[C@@]([C@@H]3O[C@@H]([C@H]4O[C@@](O)(CO)[C@H](C)C[C@@H]4C)C[C@@H]3C)(C)CC2)O[C@]1([C@@H](C)[C@H](OC)C5)O[C@@H]5C[C@@H]6O[C@@H]([C@H](C)C(O)=O)[C@@H](C)CC6—
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