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BGC0002032PKS

pentamycin

Producing organism
Streptomyces sp. S816
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS(Unknown)
Total steps
18
DOI
MIBiG entry
View on MIBiG ↗
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pentamycin
C35H58O12670.39 Da

Gene Cluster Map15 genes · 81,641 bp

KSKSKSKSKSKSKSKSKSKSKSKSKSKS20 kb81.6 kb visible · 81,641 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1Load
DV517_01410
+Acetyl-CoA
Inactive: KS
Step 2M1
DV517_01410
+Malonyl-CoA
Step 3M2
DV517_01410
+Malonyl-CoA
Step 4M3
DV517_01410
+Malonyl-CoA
Step 5M4
DV517_01410
+Malonyl-CoA
Step 6M5
DV517_01400
+Malonyl-CoA
Step 7M6
DV517_01400
+Methylmalonyl-CoA
Step 8M7
DV517_01390
+Malonyl-CoA
Inactive: DH
Step 9M8
DV517_01380
+Malonyl-CoA
Step 10M9
DV517_01380
+Malonyl-CoA
Step 11M10
DV517_01380
+Malonyl-CoA
Step 12M11
DV517_01380
+Malonyl-CoA
Step 13M12
DV517_01370
+Malonyl-CoA
Step 14M13
DV517_01370
+Hexylmalonyl-CoA
Step 15TE
DV517_01370
Step 16
DV517_01350
Step 17
DV517_01340
Step 18
DV517_01420
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12032-1DV517_01410Loading
Acetyl-CoA
O=C(C)O{'Inactive':['KS']}
22032-2DV517_01410M1
2032-1;Malonyl-CoA
from: 2032-1
O[C@H](C)CC(O)=O—
32032-3DV517_01410M2
2032-2;Malonyl-CoA
from: 2032-2
O[C@H](C)C/C=C/C(O)=O—
42032-4DV517_01410M3
2032-3;Malonyl-CoA
from: 2032-3
O[C@H](C)C/C=C/C=C/C(O)=O—
52032-5DV517_01410M4
2032-4;Malonyl-CoA
from: 2032-4
O[C@H](C)C/C=C/C=C/C=C/C(O)=O—
62032-6DV517_01400M5
2032-5;Malonyl-CoA
from: 2032-5
O[C@H](C)C/C=C/C=C/C=C/C=C/C(O)=O—
72032-7DV517_01400M6
2032-6;Methylmalonyl-CoA
from: 2032-6
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/C(O)=O—
82032-8DV517_01390M7
2032-7;Malonyl-CoA
from: 2032-7
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)CC(O)=O{'Inactive':['DH']}
92032-9DV517_01380M8
2032-8;Malonyl-CoA
from: 2032-8
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)CC(O)=O—
102032-10DV517_01380M9
2032-9;Malonyl-CoA
from: 2032-9
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)CC(O)=O—
112032-11DV517_01380M10
2032-10;Malonyl-CoA
from: 2032-10
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)CC(O)=O—
122032-12DV517_01380M11
2032-11;Malonyl-CoA
from: 2032-11
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)CC(O)=O—
132032-13DV517_01370M12
2032-12;Malonyl-CoA
from: 2032-12
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)CC(O)=O—
142032-14DV517_01370M13
2032-13;Hexylmalonyl-CoA
from: 2032-13
O[C@H](C)C/C=C/C=C/C=C/C=C/C=C(C)/[C@@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C(C(O)=O)CCCCCC—
152032-15DV517_01370TE
2032-14
from: 2032-14
O[C@H](C[C@@H](C[C@@H](C[C@@H]1O)O)O)C[C@@H](O)C[C@@H](O)C[C@H](O)/C(C)=C/C=C/C=C/C=C/C=C/C[C@@H](C)OC(C1CCCCCC)=O—
162032-16DV517_01350—
2032-15
from: 2032-15
O[C@H](C[C@@H](C[C@@H](C[C@@H]1O)O)O)C[C@@H](O)C[C@@H](O)C[C@H](O)/C(C)=C/C=C/C=C/C=C/C=C/[C@H](O)[C@@H](C)OC(C1CCCCCC)=O—
172032-17DV517_01340—
2032-16
from: 2032-16
O[C@H](C[C@@H](C[C@@H](C[C@@H]1O)O)O)C[C@@H](O)C[C@@H](O)C[C@H](O)/C(C)=C/C=C/C=C/C=C/C=C/[C@H](O)[C@@H](C)OC(C1[C@H](O)CCCCC)=O—
182032DV517_01420—
2032-17
from: 2032-17
O[C@H](C[C@@H](C[C@@H](C[C@@H]1O)O)O)C[C@@H](O)C[C@@H](O)[C@@H](O)[C@H](O)/C(C)=C/C=C/C=C/C=C/C=C/[C@H](O)[C@@H](C)OC(C1[C@H](O)CCCCC)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture