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BGC0002022PKS

armeniaspirol A;armeniaspirol B;armeniaspirol C

Producing organism
Streptomyces armeniacus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS(unknown)
Total steps
15
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map36 genes · 59,614 bp

AKSATKSATKRKSATCALKSA10 kb59.6 kb visible · 59,614 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
TDTerminal reductase
ACPSACP synthase
CALCoA-ligase (CAL)

Pathway Graphsteps arranged in biosynthetic order

15 steps · 14 edges
Step 1
start
+Proline
Step 7
start
+6-Methylheptanoyl…
Step 2
ams4;ams21
Step 8
ams13/ams14
Step 3
ams3
Step 4
ams22
Step 5M1
ams6
+malonyl-CoA
Step 6M2
ams6
+malonyl-CoA
Inactive: DH, KR
Step 9M3
ams7
Step 10MTD
ams7
Step 11
ams15
Step 12
ams16
Step 13
ams16
Step 14
ams16
Step 15
ams16
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions15 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12022-1start—
Proline
OC([C@H]1NCCC1)=O—
22022-2ams4;ams21—
2022-1
from: 2022-1
OC([C@H]1NCCC1)=O—
32022-3ams3—
2022-2
from: 2022-2
OC(C1=CC=CN1)=O—
42022-4ams22—
2022-3
from: 2022-3
OC(C1=C(Cl)C(Cl)=C(Cl)N1)=O—
52022-5ams6M1
2022-4;malonyl-CoA
from: 2022-4
O=C(CC(O)=O)C1=C(Cl)C(Cl)=C(Cl)N1—
62022-6ams6M2
2022-5;malonyl-CoA
from: 2022-5
O=C(CC(CC(O)=O)=O)C1=C(Cl)C(Cl)=C(Cl)N1{'Inactive':['DH','KR']}
72022-7start—
6-Methylheptanoyl-CoA/Octanoyl-CoA/6-Methyloctanoyl-CoA
O=C(CCCCC([R])C[R*])O—
82022-8ams13/ams14—
2022-7
from: 2022-7
O=C(C(C(O)=O)CCCC([R])C[R*])O—
92022-9ams7M3
2022-6;2022-8
from: 2022-6, 2022-8
O=C(CC(C(CCCC([R])C[R*])C(O)=O)=O)C1=C(Cl)C(Cl)=C(Cl)N1—
102022-10ams7MTD
2022-9
from: 2022-9
[R]C(CCCC1=C(O)C(C(C2=C(Cl)C(Cl)=C(Cl)N2)=O)=CC=C1O)C[R*]—
112022-11ams15—
2022-10
from: 2022-10
[R]C(CCCC1=C(OC23C(Cl)=C(Cl)C(N3)=O)C(C2=O)=CC=C1O)C[R*]—
122022-12ams16—
2022-11
from: 2022-11
[R]C(CCCC1=C(O[C@@]23C(Cl)=C(Cl)C(N3C)=O)C(C2=O)=CC=C1O)C[R*]—
132022(1)ams16—
2022-11
from: 2022-11
[H]C(CCCC1=C(O[C@@]23C(Cl)=C(Cl)C(N3C)=O)C(C2=O)=CC=C1O)CC—
142022(2)ams16—
2022-11
from: 2022-11
CC(CCCC1=C(O[C@@]23C(Cl)=C(Cl)C(N3C)=O)C(C2=O)=CC=C1O)C[H]—
152022(3)ams16—
2022-11
from: 2022-11
CC(CCCC1=C(O[C@@]23C(Cl)=C(Cl)C(N3C)=O)C(C2=O)=CC=C1O)CC—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture