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BGC0002011PKS

ansacarbamitocin A

Producing organism
Amycolatopsis alba DSM 44262
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Amycolatopsis
Biosynthetic class
PKS (unknown)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map69 genes · 108,788 bp

20 kb108.8 kb visible · 108,788 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
ACPAcyl carrier (ACP)
DnDocking N-term
DcDocking C-term
CycPolyketide cyclase
CALCoA-ligase (CAL)
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1Load
AMYAL_RS50235
+AHBA
Step 13
Start
+Glucose
Step 2M1
AMYAL_RS50235
+methylmalonyl-CoA
Step 14
?
Step 3M2
AMYAL_RS50235
+malonyl-CoA
Step 4M3
AMYAL_RS47360
+methoxymalonyl-ACP
Step 5M4
AMYAL_RS47360
+malonyl-CoA
Step 6M5
AMYAL_RS0139460
+methylmalonyl-CoA
Step 7M6
AMYAL_RS49685
+methylmalonyl-CoA
Step 8M7
AMYAL_RS49685
+malonyl-CoA
Inactive: DH
Step 9
AMYAL_RS0139605
Step 10
AMYAL_RS0139550
Step 11
AMYAL_RS0139495,AMYAL_R…
Step 12
AMYAL_RS0139555
Step 15
AMYAL_RS0139505
Step 16
AMYAL_RS47350
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12011-1AMYAL_RS50235Loading
AHBA
OC(C1=CC(O)=CC(N)=C1)=O—
22011-2AMYAL_RS50235M1
2011-1;methylmalonyl-CoA
from: 2011-1
OC1=CC(N)=CC(CC(C)C(O)=O)=C1—
32011-3AMYAL_RS50235M2
2011-2;malonyl-CoA
from: 2011-2
OC1=CC(N)=CC(CC(C)/C=C/C(O)=O)=C1—
42011-4AMYAL_RS47360M3
2011-3;methoxymalonyl-ACP
from: 2011-3
OC1=CC(N)=CC(CC(C)/C=C/C=C(OC)/C(O)=O)=C1—
52011-5AMYAL_RS47360M4
2011-4;malonyl-CoA
from: 2011-4
OC1=CC(N)=CC(CC(C)/C=C/C=C(OC)/C(CC(O)=O)=O)=C1—
62011-6AMYAL_RS0139460M5
2011-5;methylmalonyl-CoA
from: 2011-5
OC1=CC(N)=CC(CC(C)/C=C/C=C(OC)/C(CC(O)C(C)C(O)=O)=O)=C1—
72011-7AMYAL_RS49685M6
2011-6;methylmalonyl-CoA
from: 2011-6
OC1=CC(N)=CC(CC(C)/C=C/C=C(OC)/C(CC(O)C(C)/C=C(C)/C(O)=O)=O)=C1—
82011-8AMYAL_RS49685M7
2011-7;malonyl-CoA
from: 2011-7
OC1=CC(N)=CC(CC(C)/C=C/C=C(OC)/C(CC(O)C(C)/C=C(C)/C(O)CC(O)=O)=O)=C1{'Inactive':['DH']}
92011-9AMYAL_RS0139605—
2011-8
from: 2011-8
C/C([C@@H](O)CC(NC1=CC(O)=CC(C/C(C)=C/C=C/[C@@H](OC)C2=O)=C1)=O)=C\[C@@H]([C@@H](O)C2)C—
102011-10AMYAL_RS0139550—
2011-9
from: 2011-9
C/C([C@@H](O)CC(NC1=C(Cl)C(O)=CC(C/C(C)=C/C=C/[C@@H](OC)C2=O)=C1)=O)=C\[C@@H]([C@@H](O)C2)C—
112011-11AMYAL_RS0139495,AMYAL_RS0139500—
2011-10
from: 2011-10
C/C([C@@H](OC(NC)=O)CC(NC1=C(Cl)C(O)=CC(C/C(C)=C/C=C/[C@@H](OC)[C@@](N2)(O)C[C@]3([H])OC2=O)=C1)=O)=C\[C@@H]3C—
122011-12AMYAL_RS0139555—
2011-11
from: 2011-11
C[C@]12[C@@H](OC(NC)=O)CC(NC3=C(Cl)C(O)=CC(C/C(C)=C/C=C/[C@@H](OC)[C@@](N4)(O)C[C@@](OC4=O)([H])[C@@H](C)C1O2)=C3)=O—
132011-13Start—
Glucose
OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O—
142011-14?—
2011-13
from: 2011-13
O[C@@H]1[C@@H](O)[C@H](OC(N)=O)[C@@H](COC(C)=O)OC1O—
152011-15AMYAL_RS0139505—
2011-12;2011-14
from: 2011-12, 2011-14
C[C@]12[C@@H](OC(NC)=O)CC(N([C@H]3[C@H](O)[C@@H](O)[C@H](OC(N)=O)[C@@H](COC(C)=O)O3)C4=C(Cl)C(O)=CC(C/C(C)=C/C=C/[C@@H](OC)[C@@](N5)(O)C[C@@](OC5=O)([H])[C@@H](C)[C@]1([H])O2)=C4)=O—
162011AMYAL_RS47350—
2011-15
from: 2011-15
C[C@]12[C@@H](OC(NC)=O)CC(N([C@H]3[C@H](O)[C@@H](OC)[C@H](OC(N)=O)[C@@H](COC(C)=O)O3)C4=C(Cl)C(O)=CC(C/C(C)=C/C=C/[C@@H](OC)[C@@](N5)(O)C[C@@](OC5=O)([H])[C@@H](C)[C@]1([H])O2)=C4)=O—
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