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BGC0002010NRPS

streptophenazine B;streptophenazine C;streptophenazine F;streptophenazine G;streptophenazine H

Producing organism
Streptomyces sp. CNB091
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
16
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map28 genes · 36,734 bp

CALERKSATTEKSAA5 kb36.7 kb visible · 36,734 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
EREnoylreductase (ER)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
CALCoA-ligase (CAL)

Pathway Graphsteps arranged in biosynthetic order

16 steps · 15 edges
Step 1
Start
+Chorismic acid
Step 3
start
+?
Step 2
D581_RS0125540,D581_RS0…
Step 4
D581_RS0125480
Step 5
D581_RS0125495
Step 7
D581_RS0125510;(D581_RS…
Step 6
D581_RS0125485
Step 8
D581_RS01000000137725;D…
Step 9
D581_RS0125495
Step 10TE
D581_RS01000000137720
Step 11TE
D581_RS01000000137720
Step 12
D581_RS0125585/D581_RS0…
Step 13
D581_RS0125585/D581_RS0…
Step 14
D581_RS0125585/D581_RS0…
Step 15
D581_RS0125585/D581_RS0…
Step 16
D581_RS0125585/D581_RS0…
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions16 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12010-1Start—
Chorismic acid
O=C(O)C1=C[C@@H](OC(C(O)=O)=C)[C@H](O)C=C1—
22010-2D581_RS0125540,D581_RS0125545,D581_RS0125550,D581_RS0125555,D581_RS0125560,D581_RS0125565—
2010-1
from: 2010-1
O=C(C1=C(N=C(C=CC=C2C(O)=O)C2=N3)C3=CC=C1)O—
32010-3start—
?
O=C([R*])[R]—
42010-4D581_RS0125480—
2010-3
from: 2010-3
O=C([R*])CC([R])=O—
52010-5D581_RS0125495—
2010-4
from: 2010-4
O=C([R*])/C=C/[R]—
62010-6D581_RS0125485—
2010-5
from: 2010-5
O=C([R*])C(C[R])C(O)=O—
72010-7D581_RS0125510;(D581_RS0125515, D581_RS0125520)—
2010-2
from: 2010-2
O=C(C1=C(N=C(C=CC=C2C(O)=O)C2=N3)C3=CC=C1)O—
82010-8D581_RS01000000137725;D581_RS01000000137715—
2010-6;2010-7
from: 2010-6, 2010-7
O=C(C(C(O)=O)C[R])C1=CC=CC2=NC3=C(C(O)=O)C=CC=C3N=C21—
92010-9D581_RS0125495—
2010-8
from: 2010-8
O[C@@H](C(C(O)=O)C[R])C1=CC=CC2=NC3=C(C(O)=O)C=CC=C3N=C21—
102010-10D581_RS01000000137720TE
2010-9
from: 2010-9
O[C@@H](C(C(O)=O)C[R])C1=CC=CC2=NC3=C(C(O)=O)C=CC=C3N=C21—
112010(1)D581_RS01000000137720TE
2010-9
from: 2010-9
O[C@@H]([C@H](C(OC)=O)CCCC(C)C)C1=CC=CC2=NC3=C(C(O)=O)C=CC=C3N=C21—
122010-11D581_RS0125585/D581_RS0125595—
2010-10
from: 2010-10
O[C@@H](C(C(O)=O)C[R])C1=CC=CC2=NC3=C(C(OC)=O)C=CC=C3N=C21—
132010(2)D581_RS0125585/D581_RS0125595—
2010-10
from: 2010-10
O[C@@H]([C@H](C(OC)=O)CCCCC)C1=CC=CC2=NC3=C(C(OC)=O)C=CC=C3N=C21—
142010(3)D581_RS0125585/D581_RS0125595—
2010-10
from: 2010-10
O[C@@H]([C@H](C(OC)=O)CCCC(C)C)C1=CC=CC2=NC3=C(C(OC)=O)C=CC=C3N=C21—
152010(4)D581_RS0125585/D581_RS0125595—
2010-10
from: 2010-10
O[C@@H]([C@H](C(OC)=O)CCC(C)CC)C1=CC=CC2=NC3=C(C(OC)=O)C=CC=C3N=C21—
162010(5)D581_RS0125585/D581_RS0125595—
2010-10
from: 2010-10
O[C@@H]([C@H](C(OC)=O)CCCC(C)(O)C)C1=CC=CC2=NC3=C(C(OC)=O)C=CC=C3N=C21—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture