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BGC0002009NRPS

kanglemycin A;kanglemycin V1;kanglemycin V2

Producing organism
Amycolatopsis vancoresmycina
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Amycolatopsis
Biosynthetic class
NRPS (Type I)
Total steps
21
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map45 genes · 97,243 bp

20 kb97.2 kb visible · 97,243 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
CALCoA-ligase (CAL)
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

21 steps · 20 edges
Step 1Load
OO60_RS14220
+AHBA
Step 18
Start
+β-O-3,4−O,O’-meth…
Step 2M1
OO60_RS14220
+Methylmalonyl-CoA
Step 3M2
OO60_RS14220
+Malonyl-CoA
Step 4M3
OO60_RS14220
+Methylmalonyl-CoA
Step 5
OO60_RS14065
Step 6M4
OO60_RS14215
+Methylmalonyl-CoA
Step 7M5
OO60_RS14215
+Methylmalonyl-CoA
Step 8M6
OO60_RS14215
+Methylmalonyl-CoA
Step 9M7
OO60_RS14210
+Methylmalonyl-CoA
Step 10M8
OO60_RS14205
+Ethylmalonyl-CoA
Step 11M9
OO60_RS14200
+Malonyl-CoA
Step 12M10
OO60_RS14200
+Methylmalonyl-CoA
Step 13
OO60_RS14195
Step 14
OO60_RS14235
Step 15
?
Step 16
OO60_RS14240,OO60_RS141…
Step 17
OO60_RS14060
Step 19
?
Step 20
?
+2009(1)
Step 21
?
+2009(2)
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions21 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
12009-1OO60_RS14220Loading
AHBA
OC1=CC(N)=CC(C(O)=O)=C1—
22009-2OO60_RS14220M1
2009-1;Methylmalonyl-CoA
from: 2009-1
OC1=CC(N)=CC(C(C(C(O)=O)C)O)=C1—
32009-3OO60_RS14220M2
2009-2;Malonyl-CoA
from: 2009-2
OC1=CC(N)=CC(C(C(C(CC(O)=O)=O)C)O)=C1—
42009-4OO60_RS14220M3
2009-3;Methylmalonyl-CoA
from: 2009-3
OC1=CC(N)=CC(C(C(C(CC(C(C)C(O)=O)=O)=O)C)O)=C1—
52009-5OO60_RS14065—
2009-4
from: 2009-4
OC1=C(C(C(C)C(O)=O)=O)C2=C(C(C(N)=CC2=O)=O)C(O)C1C—
62009-6OO60_RS14215M4
2009-5;Methylmalonyl-CoA
from: 2009-5
OC1=C(C(/C(C)=C/C(C)C(O)=O)=O)C2=C(C(C(N)=CC2=O)=O)C(O)C1C—
72009-7OO60_RS14215M5
2009-6;Methylmalonyl-CoA
from: 2009-6
OC1=C(C(/C(C)=C/C(C)C(O)C(C)C(O)=O)=O)C2=C(C(C(N)=CC2=O)=O)C(O)C1C—
82009-8OO60_RS14215M6
2009-7;Methylmalonyl-CoA
from: 2009-7
OC1=C(C(/C(C)=C/C(C)C(O)C(C)C(O)C(C)C(O)=O)=O)C2=C(C(C(N)=CC2=O)=O)C(O)C1C—
92009-9OO60_RS14210M7
2009-8;Methylmalonyl-CoA
from: 2009-8
OC1=C(C(/C(C)=C/C(C)C(O)C(C)C(O)C(C)C(O)C(C)C(O)=O)=O)C2=C(C(C(N)=CC2=O)=O)C(O)C1C—
102009-10OO60_RS14205M8
2009-9;Ethylmalonyl-CoA
from: 2009-9
OC1=C(C(/C(C)=C/C(C)C(O)C(C)C(O)C(C)C(O)C(C)C(O)C(CC)C(O)=O)=O)C2=C(C(C(N)=CC2=O)=O)C(O)C1C—
112009-11OO60_RS14200M9
2009-10;Malonyl-CoA
from: 2009-10
OC1=C(C(/C(C)=C/C(C)C(O)C(C)C(O)C(C)C(O)C(C)C(O)C(CC)/C=C/C(O)=O)=O)C2=C(C(C(N)=CC2=O)=O)C(O)C1C—
122009-12OO60_RS14200M10
2009-11;Methylmalonyl-CoA
from: 2009-11
OC1=C(C(/C(C)=C/C(C)C(O)C(C)C(O)C(C)C(O)C(C)C(O)C(CC)/C=C/C=C(C)/C(O)=O)=O)C2=C(C(C(N)=CC2=O)=O)C(O)C1C—
132009-13OO60_RS14195—
2009-12
from: 2009-12
CC(C(O)C(/C=C1/C)C)C(O)C(C)C(C(C)C(C(CC)/C=C/C=C(C)\C(NC(C(C2=C3C(C1=O)=C(O)C(C2O)C)=O)=CC3=O)=O)O)O—
142009-14OO60_RS14235—
2009-13
from: 2009-13
CC(C(O)C(/C=C1/C)C)C(O)C(C)C(C(C)C(C(CC)/C=C/C=C(C)\C(NC(C(C2=C3C(C1=O)=C(O)C(C)=C2O)=O)=CC3=O)=O)O)O—
152009-15?—
2009-14
from: 2009-14
CC(C(O)C(/C=C1/C)CO)C(O)C(C)C(C(C)C(C(CC)/C=C/C=C(C)\C(NC(C(C2=C3C(C1=O)=C(O)C(C)=C2O)=O)=CC3=O)=O)O)O—
162009-16OO60_RS14240,OO60_RS14105—
2009-15
from: 2009-15
CC(C(O)/C=C/OC1(C)OC2=C(C1=O)C3=C(C(C(N4)=CC3=O)=O)C(O)=C2C)C(O)C(C)C(C(C)C(C(CC)/C=C/C=C(C)\C4=O)O)O—
172009-17OO60_RS14060—
2009-16
from: 2009-16
CC(C(O)/C=C/C1C)C(OC(C)=O)C(C)C(C(C)C(C(CC)/C=C/C=C(C)\C(NC(C(C2=C3C(C4=O)=C(OC41C)C(C)=C2O)=O)=CC3=O)=O)O)O—
182009-18Start—
β-O-3,4−O,O’-methylene digitoxose
C[C@H]1OC(O)CC2[C@@H]1OCO2—
192009(1)?—
2009-17;2009-18
from: 2009-17, 2009-18
CC(C(OC1O[C@H](C)[C@@H](OCO2)C2C1)/C=C/C3C)C(OC(C)=O)C(C)C(C(C)C(C(C(C)OC(C(C)(C)CC(O)=O)=O)/C=C/C=C(C)\C(NC(C(C4=C5C(C6=O)=C(OC63C)C(C)=C4O)=O)=CC5=O)=O)O)O—
202009(2)?—
2009(1)
CC(C(OC1O[C@H](C)[C@@H](OCO2)C2C1)/C=C/C3C)C(OC(C)=O)C(C)C(C(C)C(C(C(C)OC(C(C)(C)CC(O)=O)=O)/C=C/C=C(C)\C(NC(C(C4=C5C(C6O)=C(OC63C)C(C)=C4O)=O)=CC5=O)=O)O)O—
212009(3)?—
2009(2)
CC(C(OC1O[C@H](C)[C@@H](OCO2)C2C1)/C=C/C3C)C(OC(C)=O)C(C)C(C(C)C(C(C(C)OC(C(C)(C)CC(O)=O)=O)/C=C/C=C(C)\C(NC4=CC5C6=C(C4=O)C(O)=C(C(OC73C)=C6C7OCO5)C)=O)O)O—
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