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BGC0001984NRPS

Sarpeptin A;Sarpeptin B

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
19
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map12 genes · 96,578 bp

20 kb96.6 kb visible · 96,578 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Domains
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
CnCOM N-term
TEThioesterase (TE)
EEpimerization (E)
MTMethyltransferase
CALCoA-ligase (CAL)
TauDTauD oxygenase
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

19 steps · 18 edges
Step 1
Start
+Decanoic acid
Step 2
speD;speE
Step 3
spef, speG
Step 4M1
speA
{'iteration': [((None), ‘G…
Step 5M2
speA
+3-hydroxy asparti…
Step 6M3
speA
+Tyrosine
Step 7M4
speA
+Threonine
Step 8M5
speA
+Leucine
Step 9M6
speB
+3-hydroxy asparti…
Step 10M7
speB
+Glycine
Step 11M8
speB
+Proline
Step 12M9
speB
+Glycine
Step 13M10
speC
+Glycine
Step 14M11
speC
Step 15M12
speC
+Glycine
Step 16TE
speC
Step 17
speK, speJ?
Step 18
speK, speJ?
Step 19
speK, speJ?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions19 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11984-1Start—
Decanoic acid
CC(CCCCCCC(O)=O)[R]—
21984-2speD;speE—
1984-1
from: 1984-1
CC(CCCCCCC(O)=O)[R]—
31984-3spef, speG—
1984-2
from: 1984-2
CC(CC/C=C\C=C\C(O)=O)[R]—
41984-4speAM1
1984-3
from: 1984-3
CC(CC/C=C\C=C\C(NCC(NCC(O)=O)=O)=O)[R]{'iteration': [((None), ‘Gly…
51984-5speAM2
1984-4;3-hydroxy aspartic acid
from: 1984-4
CC(CC/C=C\C=C\C(NCC(NCC(NC(C(O)=O)C(O)C(O)=O)=O)=O)=O)[R]—
61984-6speAM3
1984-5;Tyrosine
from: 1984-5
CC(CC/C=C\C=C\C(NCC(NCC(NC(C(N[C@H](C(O)=O)CC1=CC=C(O)C=C1)=O)C(O)C(O)=O)=O)=O)=O)[R]—
71984-7speAM4
1984-6;Threonine
from: 1984-6
CC(CC/C=C\C=C\C(NCC(NCC(NC(C(N[C@H](C(N[C@@H]([C@@H](C)O)C(O)=O)=O)CC1=CC=C(O)C=C1)=O)C(O)C(O)=O)=O)=O)=O)[R]—
81984-8speAM5
1984-7;Leucine
from: 1984-7
CC(CC/C=C\C=C\C(NCC(NCC(NC(C(N[C@H](C(N[C@@H]([C@@H](C)O)C(N[C@H](CC(C)C)C(O)=O)=O)=O)CC1=CC=C(O)C=C1)=O)C(O)C(O)=O)=O)=O)=O)[R]—
91984-9speBM6
1984-8;3-hydroxy aspartic acid
from: 1984-8
CC(CC/C=C\C=C\C(NCC(NCC(NC(C(N[C@H](C(N[C@@H]([C@@H](C)O)C(N[C@H](CC(C)C)C(NC(C(C(O)=O)O)C(O)=O)=O)=O)=O)CC1=CC=C(O)C=C1)=O)C(O)C(O)=O)=O)=O)=O)[R]—
101984-10speBM7
1984-9;Glycine
from: 1984-9
CC(CC/C=C\C=C\C(NCC(NCC(NC(C(N[C@H](C(N[C@@H]([C@@H](C)O)C(N[C@H](CC(C)C)C(NC(C(C(O)=O)O)C(NCC(O)=O)=O)=O)=O)=O)CC1=CC=C(O)C=C1)=O)C(O)C(O)=O)=O)=O)=O)[R]—
111984-11speBM8
1984-10;Proline
from: 1984-10
CC(CC/C=C\C=C\C(NCC(NCC(NC(C(N[C@H](C(N[C@@H]([C@@H](C)O)C(N[C@H](CC(C)C)C(NC(C(C(O)=O)O)C(NCC(N1CCCC1C(O)=O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)C(O)C(O)=O)=O)=O)=O)[R]—
121984-12speBM9
1984-11;Glycine
from: 1984-11
CC(CC/C=C\C=C\C(NCC(NCC(NC(C(N[C@H](C(N[C@@H]([C@@H](C)O)C(N[C@H](CC(C)C)C(NC(C(C(O)=O)O)C(NCC(N1CCCC1C(NCC(O)=O)=O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)C(O)C(O)=O)=O)=O)=O)[R]—
131984-13speCM10
1984-12;Glycine
from: 1984-12
CC(CC/C=C\C=C\C(NCC(NCC(NC(C(N[C@H](C(N[C@@H]([C@@H](C)O)C(N[C@H](CC(C)C)C(NC(C(C(O)=O)O)C(NCC(N1CCCC1C(NCC(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)C(O)C(O)=O)=O)=O)=O)[R]—
141984-14speCM11
1984-13
from: 1984-13
CC(CC/C=C\C=C\C(NCC(NCC(NC(C(N[C@H](C(N[C@@H]([C@@H](C)O)C(N[C@H](CC(C)C)C(NC(C(C(O)=O)O)C(NCC(N1CCCC1C(NCC(NCC(NC(C(O)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)C(O)C(O)=O)=O)=O)=O)[R]—
151984-15speCM12
1984-14;Glycine
from: 1984-14
CC(CC/C=C\C=C\C(NCC(NCC(NC(C(N[C@H](C(N[C@@H]([C@@H](C)O)C(N[C@H](CC(C)C)C(NC(C(C(O)=O)O)C(NCC(N1CCCC1C(NCC(NCC(NC(C(N(CC(O)=O)C)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)C(O)C(O)=O)=O)=O)=O)[R]—
161984-16speCTE
1984-15
from: 1984-15
CC(CC/C=C\C=C\C(NCC(NCC(NC(C(N[C@H](C(N[C@@H]([C@@H](C)O)C(N[C@H](CC(C)C)C(NC(C(C(O)=O)O)C(NCC(N1CCCC1C(NCC(NCC(NC(C(N(CC(O)=O)C)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)C(O)C(O)=O)=O)=O)=O)[R]—
171984-17speK, speJ?—
1984-16
from: 1984-16
CC(CC/C=C\C=C\C(NCC(NCC(NC(C(N[C@H](C(N[C@@H]([C@@H](C)O)C(N[C@H](CC(C)C)C(NC(C(C(O)=O)O)C(N)=O)=O)=O)=O)CC1=CC=C(O)C=C1)=O)C(O)C(O)=O)=O)=O)=O)[R]—
181984(1)speK, speJ?—
1984-16
from: 1984-16
CC(CC/C=C\C=C\C(NCC(NCC(NC(C(N[C@H](C(N[C@@H]([C@@H](C)O)C(N[C@H](CC(C)C)C(NC(C(C(O)=O)O)C(N)=O)=O)=O)=O)CC1=CC=C(O)C=C1)=O)C(O)C(O)=O)=O)=O)=O)[H]—
191984(2)speK, speJ?—
1984-16
from: 1984-16
CC(CC/C=C\C=C\C(NCC(NCC(NC(C(N[C@H](C(N[C@@H]([C@@H](C)O)C(N[C@H](CC(C)C)C(NC(C(C(O)=O)O)C(N)=O)=O)=O)=O)CC1=CC=C(O)C=C1)=O)C(O)C(O)=O)=O)=O)=O)C—
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