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BGC0001975NRPS

Atratumycin

Producing organism
Streptomyces atratus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
15
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map38 genes · 69,292 bp

AAAAAAAAAA10 kb69.3 kb visible · 69,292 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
CnCOM N-term
CcCOM C-term
TEThioesterase (TE)
EEpimerization (E)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

15 steps · 14 edges
Step 1
?
+?
Step 2
QBG38777.1, ?
Step 3
QBG38777.1, ?
Step 4M1
QBG38784.1
+Threonine
Step 5M2
QBG38784.1
+Serine
Step 6M3
QBG38784.1
+Tryptophan
Step 7M4
QBG38784.1
+Asparagine
Step 8M5
QBG38783.1
+Phenylalanine
Step 9
QBG38788.1
Step 10M6
QBG38783.1
+Proline
Step 11M7
QBG38783.1
+Valine
Step 12M8
QBG38782.1
+Glycine
Step 13M9
QBG38782.1
+Leucine
Step 14M10
QBG38782.1
+Tyrosine
Step 15TE
QBG38782.1
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions15 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11975-1?—
?
O=C(O)/C=C/C=C/C=C/C=C/C—
21975-2QBG38777.1, ?—
1975-1
from: 1975-1
OC(/C=C/C=C/C=C\C=C\C)=O—
31975-3QBG38777.1, ?—
1975-2
from: 1975-2
OC(/C=C/C1=C(C)C=CC=C1)=O—
41975-4QBG38784.1M1
1975-3;Threonine
from: 1975-3
C[C@@H](O)[C@@H](C(O)=O)NC(/C=C/C1=C(C)C=CC=C1)=O—
51975-5QBG38784.1M2
1975-4;Serine
from: 1975-4
C[C@@H](O)[C@@H](C(N[C@@H](CO)C(O)=O)=O)NC(/C=C/C1=C(C)C=CC=C1)=O—
61975-6QBG38784.1M3
1975-5;Tryptophan
from: 1975-5
C[C@@H](O)[C@@H](C(N[C@@H](CO)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O)=O)=O)NC(/C=C/C3=C(C)C=CC=C3)=O—
71975-7QBG38784.1M4
1975-6;Asparagine
from: 1975-6
C[C@@H](O)[C@@H](C(N[C@@H](CO)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](C(O)=O)CC(N)=O)=O)=O)=O)NC(/C=C/C3=C(C)C=CC=C3)=O—
81975-8QBG38783.1M5
1975-7;Phenylalanine
from: 1975-7
C[C@@H](O)[C@@H](C(N[C@@H](CO)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)CC(N)=O)=O)=O)=O)NC(/C=C/C4=C(C)C=CC=C4)=O—
91975-9QBG38788.1—
1975-8
from: 1975-8
C[C@@H](O)[C@@H](C(N[C@@H](CO)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](C(N[C@H](C(O)=O)[C@H](C3=CC=CC=C3)O)=O)CC(N)=O)=O)=O)=O)NC(/C=C/C4=C(C)C=CC=C4)=O—
101975-10QBG38783.1M6
1975-9;Proline
from: 1975-9
C[C@@H](O)[C@@H](C(N[C@@H](CO)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](C(N[C@H](C(N3[C@H](C(O)=O)CCC3)=O)[C@H](C4=CC=CC=C4)O)=O)CC(N)=O)=O)=O)=O)NC(/C=C/C5=C(C)C=CC=C5)=O—
111975-11QBG38783.1M7
1975-10;Valine
from: 1975-10
C[C@@H](O)[C@@H](C(N[C@@H](CO)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(C)C)C(O)=O)=O)CCC3)=O)[C@H](C4=CC=CC=C4)O)=O)CC(N)=O)=O)=O)=O)NC(/C=C/C5=C(C)C=CC=C5)=O—
121975-12QBG38782.1M8
1975-11;Glycine
from: 1975-11
C[C@@H](O)[C@@H](C(N[C@@H](CO)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(C)C)C(NCC(O)=O)=O)=O)CCC3)=O)[C@H](C4=CC=CC=C4)O)=O)CC(N)=O)=O)=O)=O)NC(/C=C/C5=C(C)C=CC=C5)=O—
131975-13QBG38782.1M9
1975-12;Leucine
from: 1975-12
C[C@@H](O)[C@@H](C(N[C@@H](CO)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(C)C)C(NCC(N[C@H](CC(C)C)C(O)=O)=O)=O)=O)CCC3)=O)[C@H](C4=CC=CC=C4)O)=O)CC(N)=O)=O)=O)=O)NC(/C=C/C5=C(C)C=CC=C5)=O—
141975-14QBG38782.1M10
1975-13;Tyrosine
from: 1975-13
C[C@@H](O)[C@@H](C(N[C@@H](CO)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(C)C)C(NCC(N[C@H](CC(C)C)C(N[C@@H](C(O)=O)CC4=CC=C(O)C=C4)=O)=O)=O)=O)CCC3)=O)[C@H](C5=CC=CC=C5)O)=O)CC(N)=O)=O)=O)=O)NC(/C=C/C6=C(C)C=CC=C6)=O—
151975QBG38782.1TE
1975-14
from: 1975-14
O=C(N[C@H](CC(N)=O)C(N[C@H](C(N1[C@H](C(N[C@@H](C(NCC(N[C@@H]2CC(C)C)=O)=O)C(C)C)=O)CCC1)=O)[C@@H](O)C3=CC=CC=C3)=O)[C@@H](NC([C@@H](NC([C@H]([C@H](OC([C@@H](CC4=CC=C(O)C=C4)NC2=O)=O)C)NC(/C=C/C5=C(C)C=CC=C5)=O)=O)CO)=O)CC6=CNC7=C6C=CC=C7—
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