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BGC0001967Hybrid

Acyldepsipeptide 1

Producing organism
Streptomyces hawaiiensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
14
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map19 genes · 36,600 bp

ERKSCACACACAMTCACATE5 kb36.6 kb visible · 36,600 bp total
Biosynthetic (core)
Biosynthetic (additional)
Unknown
Domains
KSKetosynthase (KS)
EREnoylreductase (ER)
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
MTMethyltransferase

Pathway Graphsteps arranged in biosynthetic order

14 steps · 12 edges
Step 1
adeC, adeD, adeE, adeF,…
+Acetyl-CoA, Malonyl-CoA
Step 7
Start
+L-leucine
Step 2M1
adeG
+Phenylalanine
Step 8
adeA
Step 3M2
adeG
+Serine
Step 9
adeB
Step 4M3
adeG
+Proline
Step 10
Step 5M4
adeG
+Alanine
Step 11
adeC?
Step 6M5
adeH
+Alanine
Step 12M6
adeH
+(1967-11/Proline)
Step 13TE
adeH
Step 14TE
adeH
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions14 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11967-1adeC, adeD, adeE, adeF, ?—
Acetyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA
OC(/C=C/C=C/C=C/C)=O—
21967-2adeGM1
1967-1;Phenylalanine
from: 1967-1
O=C(O)[C@H](CC1=CC=CC=C1)NC(/C=C/C=C/C=C/C)=O—
31967-3adeGM2
1967-2;Serine
from: 1967-2
O=C(N[C@@H](CO)C(O)=O)[C@H](CC1=CC=CC=C1)NC(/C=C/C=C/C=C/C)=O—
41967-4adeGM3
1967-3;Proline
from: 1967-3
O=C(N[C@@H](CO)C(N1CCC[C@H]1C(O)=O)=O)[C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C=C/C)=O—
51967-5adeGM4
1967-4;Alanine
from: 1967-4
O=C(N[C@@H](CO)C(N1CCC[C@H]1C(N(C)[C@@H](C)C(O)=O)=O)=O)[C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C=C/C)=O—
61967-6adeHM5
1967-5;Alanine
from: 1967-5
O=C(N[C@@H](CO)C(N1CCC[C@H]1C(N(C)[C@@H](C)C(N[C@@H](C)C(O)=O)=O)=O)=O)[C@H](CC2=CC=CC=C2)NC(/C=C/C=C/C=C/C)=O—
71967-7Start—
L-leucine
CC(C)C[C@H](N)C(O)=O—
81967-8adeA—
1967-7
from: 1967-7
C[C@@H](CO)C[C@H](N)C(O)=O—
91967-9adeB—
1967-8
from: 1967-8
C[C@@H](C=O)C[C@H](N)C(O)=O—
101967-10—
1967-9
from: 1967-9
OC([C@@H]1C[C@@H](C)C=N1)=O—
111967-11adeC?—
1967-10
from: 1967-10
OC([C@@H]1C[C@@H](C)CN1)=O—
121967-12adeHM6
1967-6;(1967-11/Proline)
from: 1967-6
O=C(N[C@@H](CO)C(N1CCC[C@H]1C(N(C)[C@@H](C)C(N[C@@H](C)C(N2C[C@H]([R])CC2C(O)=O)=O)=O)=O)=O)[C@H](CC3=CC=CC=C3)NC(/C=C/C=C/C=C/C)=O—
131967-13adeHTE
1967-12
from: 1967-12
O=C([C@H](C)NC1=O)N(C[C@H]([R])C2)[C@@H]2C(OC[C@H](NC([C@@H](NC(/C=C/C=C/C=C/C)=O)CC3=CC=CC=C3)=O)C(N(CCC4)[C@@H]4C(N(C)[C@H]1C)=O)=O)=O—
141967adeHTE
1967-12
from: 1967-12
O=C([C@H](C)NC1=O)N(C[C@H](C)C2)[C@@H]2C(OC[C@H](NC([C@@H](NC(/C=C/C=C/C=C/C)=O)CC3=CC=CC=C3)=O)C(N(CCC4)[C@@H]4C(N(C)[C@H]1C)=O)=O)=O—
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