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BGC0001963PKS

Catenulisporolide A;Catenulisporolide B;Catenulisporolide C;Catenulisporolide D

Producing organism
Catenulispora sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Catenulisporales›Catenulisporaceae›Catenulispora
Biosynthetic class
PKS (Type I)
Total steps
23
DOI
MIBiG entry
View on MIBiG ↗
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C58H100O20

Gene Cluster Map56 genes · 154,666 bp

20 kb154.7 kb visible · 154,666 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
ACPSACP synthase
CALCoA-ligase (CAL)
AmTAminotransferase III
TauDTauD oxygenase

Pathway Graphsteps arranged in biosynthetic order

23 steps · 27 edges
Step 1Load
AZF85917.1
+Isovaleryl-CoA
Step 18
Start
+L-oleandrose
Step 19
Start
+D-olivose
Step 2M1
AZF85917.1
+Methylmalonyl-CoA
Step 3M2
AZF85917.1
+Methylmalonyl-CoA
Step 4M3
AZF85945.1
+Malonyl-CoA
Step 5M4
AZF85945.1
+Methylmalonyl-CoA
Step 6M5
AZF85945.1
+Malonyl-CoA
Step 7M6
AZF85946.1
+Malonyl-CoA
Step 8M7
AZF85946.1
+Malonyl-CoA
Step 9M8
AZF85946.1
+Malonyl-CoA
Step 10M9
AZF85946.1
+Malonyl-CoA
Step 11M10
AZF85947.1
+Malonyl-CoA
Step 12M11
AZF85947.1
+Methylmalonyl-CoA
Step 13M12
AZF85947.1
+Malonyl-CoA
Step 14M13
AZF85947.1
+Malonyl-CoA
Step 15M14
AZF85947.1;AZF85941.1
+Malonyl-CoA
Step 16M15
AZF85941.1
+Malonyl-CoA
Step 17TE
AZF85941.1
Step 20
?
Step 21
?
Step 22
?
Step 23
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions23 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11963-1AZF85917.1Loading
Isovaleryl-CoA
CC(C)CC(O)=O—
21963-2AZF85917.1M1
1963-1;Methylmalonyl-CoA
from: 1963-1
CC(C)C[C@H](O)[C@H](C)C(O)=O—
31963-3AZF85917.1M2
1963-2;Methylmalonyl-CoA
from: 1963-2
CC(C)C[C@H](O)[C@H](C)[C@H](O)[C@@H](C)C(O)=O—
41963-4AZF85945.1M3
1963-3;Malonyl-CoA
from: 1963-3
CC(C)C[C@H](O)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)CC(O)=O—
51963-5AZF85945.1M4
1963-4;Methylmalonyl-CoA
from: 1963-4
CC(C)C[C@H](O)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)C[C@@H](O)[C@@H](C)C(O)=O—
61963-6AZF85945.1M5
1963-5;Malonyl-CoA
from: 1963-5
CC(C)C[C@H](O)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)C[C@@H](O)[C@@H](C)/C=C/C(O)=O—
71963-7AZF85946.1M6
1963-6;Malonyl-CoA
from: 1963-6
CC(C)C[C@H](O)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)C[C@@H](O)[C@@H](C)/C=C/C=C/C(O)=O—
81963-8AZF85946.1M7
1963-7;Malonyl-CoA
from: 1963-7
CC(C)C[C@H](O)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)C[C@@H](O)[C@@H](C)/C=C/C=C/C=C/C(O)=O—
91963-9AZF85946.1M8
1963-8;Malonyl-CoA
from: 1963-8
CC(C)C[C@H](O)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)C[C@@H](O)[C@@H](C)/C=C/C=C/C=C/[C@@H](O)CC(O)=O—
101963-10AZF85946.1M9
1963-9;Malonyl-CoA
from: 1963-9
CC(C)C[C@H](O)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)C[C@@H](O)[C@@H](C)/C=C/C=C/C=C/[C@@H](O)C[C@@H](O)CC(O)=O—
111963-11AZF85947.1M10
1963-10;Malonyl-CoA
from: 1963-10
CC(C)C[C@H](O)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)C[C@@H](O)[C@@H](C)/C=C/C=C/C=C/[C@@H](O)C[C@@H](O)C[C@@H](O)CC(O)=O—
121963-12AZF85947.1M11
1963-11;Methylmalonyl-CoA
from: 1963-11
CC(C)C[C@H](O)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)C[C@@H](O)[C@@H](C)/C=C/C=C/C=C/[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)[C@@H](C)C(O)=O—
131963-13AZF85947.1M12
1963-12;Malonyl-CoA
from: 1963-12
CC(C)C[C@H](O)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)C[C@@H](O)[C@@H](C)/C=C/C=C/C=C/[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)[C@@H](C)C(CC(O)=O)=O—
141963-14AZF85947.1M13
1963-13;Malonyl-CoA
from: 1963-13
CC(C)C[C@H](O)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)C[C@@H](O)[C@@H](C)/C=C/C=C/C=C/[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)[C@@H](C)C(C[C@H](O)CC(O)=O)=O—
151963-15AZF85947.1;AZF85941.1M14
1963-14;Malonyl-CoA
from: 1963-14
CC(C)C[C@H](O)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)C[C@@H](O)[C@@H](C)/C=C/C=C/C=C/[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)[C@@H](C)C(C[C@H](O)CCCC(O)=O)=O—
161963-16AZF85941.1M15
1963-15;Malonyl-CoA
from: 1963-15
CC(C)C[C@H](O)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)C[C@@H](O)[C@@H](C)/C=C/C=C/C=C/[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)[C@@H](C)C(C[C@H](O)CCCCCC(O)=O)=O—
171963-17AZF85941.1TE
1963-16
from: 1963-16
C[C@H]1/C=C/C=C/C=C/[C@@H](O)C[C@@H](O)C[C@@H]2C[C@H](O)[C@@H](C)[C@@](C[C@H](O)CCCCCC(O[C@@H]1C[C@@H](O)[C@@H]([C@@H](O)[C@H]([C@@H](O)CC(C)C)C)C)=O)(O)O2—
181963-18Start—
L-oleandrose
O[C@H]1C[C@@H](OC)[C@H](O)[C@@H](C)O1—
191963-19Start—
D-olivose
O[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1—
201963(1)?—
1963-17;1963-18;1963-19;1963-19
from: 1963-17, 1963-18, 1963-19, 1963-19
C[C@H]1/C=C/C=C/C=C/[C@@H](O)C[C@@H](O[C@H]2C[C@@H](OC)[C@H](O)[C@@H](C)O2)C[C@@H]3C[C@H](O)[C@@H](C)[C@@](C[C@H](O)CCCCCC(O[C@@H]1C[C@@H](O)[C@@H]([C@@H](O)[C@H]([C@@H](O[C@H]4C[C@@H](O[C@H]5C[C@@H](O)[C@H](O)[C@@H](C)O5)[C@H](O)[C@@H](C)O4)CC(C)C)C)C)=O)(O)O3—
211963(2)?—
1963-17;1963-18;1963-19;1963-19
from: 1963-17, 1963-18, 1963-19, 1963-19
C[C@H]1/C=C/C=C/C=C\[C@@H](O)C[C@@H](O[C@H]2C[C@@H](OC)[C@H](O)[C@@H](C)O2)C[C@@H]3C[C@H](O)[C@@H](C)[C@@](C[C@H](O)CCCCCC(O[C@@H]1C[C@@H](O)[C@@H]([C@@H](O)[C@H]([C@@H](O[C@H]4C[C@@H](O[C@H]5C[C@@H](O)[C@H](O)[C@@H](C)O5)[C@H](O)[C@@H](C)O4)CC(C)C)C)C)=O)(O)O3—
221963(3)?—
1963-17;1963-19;1963-19;1963-19
from: 1963-17, 1963-19, 1963-19, 1963-19
C[C@H]1/C=C/C=C/C=C/[C@@H](O)C[C@@H](O[C@H]2C[C@@H](O)[C@H](O)[C@@H](C)O2)C[C@@H]3C[C@H](O)[C@@H](C)[C@@](C[C@H](O)CCCCCC(O[C@@H]1C[C@@H](O)[C@@H]([C@@H](O)[C@H]([C@@H](O[C@H]4C[C@@H](O[C@H]5C[C@@H](O)[C@H](O)[C@@H](C)O5)[C@H](O)[C@@H](C)O4)CC(C)C)C)C)=O)(O)O3—
231963(4)?—
1963-17;1963-18;1963-19;1963-19
from: 1963-17, 1963-18, 1963-19, 1963-19
C[C@H]1/C=C/C=C/C=C/[C@@H](O)C[C@@H](O[C@H]2C[C@@H](OC)[C@H](O)[C@@H](C)O2)C[C@@H](O)C/C=C(C)/C(C[C@H](O)CCCCCC(O[C@@H]1C[C@@H](O)[C@@H]([C@@H](O)[C@H]([C@@H](O[C@H]3C[C@@H](O[C@H]4C[C@@H](O)[C@H](O)[C@@H](C)O4)[C@H](O)[C@@H](C)O3)CC(C)C)C)C)=O)=O—
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