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BGC0001957PKS

Amipurimycin

Producing organism
Streptomyces novoguineensis
Taxonomy
BacteriaActinomycetotaActinomycetesKitasatosporalesStreptomycetaceaeStreptomyces
Biosynthetic class
PKS (Unknown)
Total steps
18
DOI
MIBiG entry
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amipurimycin
C20H29N7O8495.21 Da

Gene Cluster Map30 genes · 32,515 bp

AmTAKSATAmTKSA5 kb32.5 kb visible · 32,515 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
KRKetoreductase (KR)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
AmTAminotransferase III
AmTAminotransferase IV

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1
Start
+Glucose
Step 6
Start
+α-Ketoglutarate
Step 12
Start
+Guanosine monopho…
Step 17
Start
+(-)-cispentacin
Step 2
?
Step 7
amc7;amc8
Step 13
amc6
Step 3
amc12;amc10
Step 14
amc15
Step 4
amc9
Step 5
amc11
Step 8
amc8
Step 9
?
Step 10
amc2, ?
Step 11
amc1
Step 15
amc4
Step 16
amc14, (amc3a, amc3b)
Step 18
amc18
Starting stepIntermediateFinal productModuleLoadingTENo modulePKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11957-1Start
Glucose
O[C@H]1[C@H](O)[C@@H](O)C(O)C[C@@H]1CO
21957-2?
1957-1
from: 1957-1
O=C(OP(O)(O)=O)[C@@H](COP(O)(O)=O)O
31957-3amc12;amc10
1957-2
from: 1957-2
O=C(O)[C@@H](CO)O
41957-4amc9
1957-3
from: 1957-3
O=C(O)[C@@H](C=O)O
51957-5amc11
1957-4
from: 1957-4
O=C(O)C(C(O)=O)O
61957-6Start
α-Ketoglutarate
O=C(O)C(CCC(O)=O)=O
71957-7amc7;amc8
1957-6
from: 1957-6
O=C(O)CCC(C(O)=O)=O
81957-8amc8
1957-7;1957-5
from: 1957-7, 1957-5
O=C([C@H](C(O)=O)O)CCC(C(O)=O)=O
91957-9?
1957-8
from: 1957-8
O=C([C@H](C(O)=O)O)CCC(C(O)=O)=O
101957-10amc2, ?
1957-9
from: 1957-9
NC(C(O)=O)[C@H](CC([C@H]1O)=O)OC1=O
111957-11amc1
1957-10
from: 1957-10
NC(C(O)=O)[C@H]1OC(O)[C@H](O)C(C1)=O
121957-12Start
Guanosine monophosphate
O=P(O)(O)OC[C@H]1O[C@@H](N2C(N=C(N)NC3=O)=C3N=C2)[C@@H](O)[C@H]1O
131957-13amc6
1957-12
from: 1957-12
O=P(O)(O)OC[C@H]1O[C@@H](N2C(N=C(N)N=C3)=C3N=C2)[C@@H](O)[C@H]1O
141957-14amc15
1957-13
from: 1957-13
NC(N=C1)=NC2=C1N=CN2
151957-15amc4
1957-11;1957-14
from: 1957-11, 1957-14
NC(C(O)=O)[C@H]1O[C@@H](N2C(N=C(N)N=C3)=C3N=C2)[C@H](O)C(C1)=O
161957-16amc14, (amc3a, amc3b)
1957-15
from: 1957-15
N[C@H](C(O)=O)[C@H]1O[C@@H](N2C(N=C(N)N=C3)=C3N=C2)[C@H](O)[C@](O)([C@@H](O)CO)C1
171957-17Start
(-)-cispentacin
O=C(O)C1C(N)CCC1
181957amc18
1957-16;1957-17
from: 1957-16, 1957-17
OC([C@@H](NC([C@H]1CCC[C@@H]1N)=O)[C@H]2O[C@@H](N3C(N=C(N)N=C4)=C4N=C3)[C@H](O)[C@](O)([C@@H](O)CO)C2)=O
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