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BGC0001956PKS

Miharamycin A;Miharamycin B

Producing organism
Streptomyces miharaensis
Taxonomy
BacteriaActinomycetotaActinomycetesKitasatosporalesStreptomycetaceaeStreptomyces
Biosynthetic class
PKS (Unknown)
Total steps
19
DOI
MIBiG entry
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C20H30N10O9554.22 Da

Gene Cluster Map27 genes · 29,240 bp

AmTAKSATKR5 kb29.2 kb visible · 29,240 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
KRKetoreductase (KR)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
FkFkbH-like
AmTAminotransferase IV

Pathway Graphsteps arranged in biosynthetic order

19 steps · 18 edges
Step 1
Start
+Glucose
Step 6
Start
+α-Ketoglutarate
Step 12
Start
+Guanosine monopho…
Step 2
?
Step 7
mhr9;mhr10
Step 13
mhr8
Step 3
mhr14;mhr12
Step 14
mhr17
Step 4
mhr11
Step 5
mhr13
Step 8
mhr10
Step 9
?
Step 10
mhr4, ?
Step 11
mhr3
Step 15
mhr6
Step 16
mhr16, (mhr5a, mhr5b)
Step 17
?
Step 18
mhr20
+L-Arginine
Step 19
mhr24
+1956(1)
Starting stepIntermediateFinal productModuleLoadingTENo modulePKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions19 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11956-1Start
Glucose
O[C@H]1[C@H](O)[C@@H](O)C(O)C[C@@H]1CO
21956-2?
1956-1
from: 1956-1
O=C(OP(O)(O)=O)[C@@H](COP(O)(O)=O)O
31956-3mhr14;mhr12
1956-2
from: 1956-2
O=C(O)[C@@H](CO)O
41956-4mhr11
1956-3
from: 1956-3
O=C(O)[C@@H](C=O)O
51956-5mhr13
1956-4
from: 1956-4
O=C(O)C(C(O)=O)O
61956-6Start
α-Ketoglutarate
O=C(O)C(CCC(O)=O)=O
71956-7mhr9;mhr10
1956-6
from: 1956-6
O=C(O)CCC(C(O)=O)=O
81956-8mhr10
1956-7;1956-5
from: 1956-7, 1956-5
O=C([C@H](C(O)=O)O)CCC(C(O)=O)=O
91956-9?
1956-8
from: 1956-8
O=C([C@H](C(O)=O)O)CCC(C(O)=O)=O
101956-10mhr4, ?
1956-9
from: 1956-9
NC(C(O)=O)[C@H](CC([C@H]1O)=O)OC1=O
111956-11mhr3
1956-10
from: 1956-10
NC(C(O)=O)[C@H]1OC(O)[C@H](O)C(C1)=O
121956-12Start
Guanosine monophosphate
O=P(O)(O)OC[C@H]1O[C@@H](N2C(N=C(N)NC3=O)=C3N=C2)[C@@H](O)[C@H]1O
131956-13mhr8
1956-12
from: 1956-12
O=P(O)(O)OC[C@H]1O[C@@H](N2C(N=C(N)N=C3)=C3N=C2)[C@@H](O)[C@H]1O
141956-14mhr17
1956-13
from: 1956-13
NC(N=C1)=NC2=C1N=CN2
151956-15mhr6
1956-11;1956-14
from: 1956-11, 1956-14
NC(C(O)=O)[C@H]1O[C@@H](N2C(N=C(N)N=C3)=C3N=C2)[C@H](O)C(C1)=O
161956-16mhr16, (mhr5a, mhr5b)
1956-15
from: 1956-15
NC(C(O)=O)[C@H]1O[C@@H](N2C(N=C(N)N=C3)=C3N=C2)[C@H](O)[C@](O)(C(O)CO)C1
171956-17?
1956-16
from: 1956-16
N[C@H](C(O)=O)[C@H]1O[C@@H](N2C(N=C(N)N=C3)=C3N=C2)[C@H](OC[C@@H]4O)[C@@]4(O)[C@@H]1O
181956(1)mhr20
1956-17;L-Arginine
from: 1956-17
OC([C@@H](NC([C@@H](N)CCCNC(N)=N)=O)[C@H]1O[C@@H](N2C(N=C(N)N=C3)=C3N=C2)[C@H](OC[C@@H]4O)[C@@]4(O)[C@@H]1O)=O
191956(2)mhr24
1956(1)
OC([C@@H](NC([C@@H](N)CCCN(O)C(N)=N)=O)[C@H]1O[C@@H](N2C(N=C(N)N=C3)=C3N=C2)[C@H](OC[C@@H]4O)[C@@]4(O)[C@@H]1O)=O
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