NPdia
← Back to Repository
BGC0001955NRPS

Keratinimicin A;Keratinimicin B;Keratinimicin C;Keratinimicin D

Producing organism
Amycolatopsis keratiniphila
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Pseudonocardiales›Pseudonocardiaceae›Amycolatopsis›Amycolatopsis japonica group
Biosynthetic class
saccharide (None);NRPS (Type I)
Total steps
18
DOI
MIBiG entry
View on MIBiG ↗
Loading…
C84H92Cl2N8O331810.51 Da

Gene Cluster Map42 genes · 71,301 bp

AAmTAAAAAAA10 kb71.3 kb visible · 71,301 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Resistance
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
CnCOM N-term
TEThioesterase (TE)
EEpimerization (E)
ECHEnoyl-CoA hydratase
AmTAminotransferase I/II
NADNAD-binding
XPutative domain (X)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

18 steps · 21 edges
Step 1M1
AYA22336.1
+D-3-chloro-4-hydr…
Step 9
Start
+L-actinosamine
Step 10
Start
+D-Glucose
Step 11
Start
+L-Fucose
Step 12
Start
Step 13
Start
+Glucuronic acid
Step 2M2
AYA22336.1
+Tyrosine
Step 3M3
AYA22335.1
+Phenylalanine
Step 4M4
AYA22334.1
+L-β-hydroxytyrosi…
Step 5M5
AYA22334.1
+L-β-hydroxytyrosi…
Step 6M6
AYA22334.1
+3-Chloro-L-Tyrosi…
Step 7M7
AYA22333.1
+L-3,5-dihydroxyph…
Step 8TE
AYA22333.1
Step 14
?
Step 15
?
Step 16
?
Step 17
?
Step 18
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11955-1AYA22336.1M1
D-3-chloro-4-hydroxyphenylglycine
ClC1=CC([C@H](C(O)=O)N)=CC=C1O—
21955-2AYA22336.1M2
1955-1;Tyrosine
from: 1955-1
ClC1=CC([C@H](C(N[C@@H](C(O)=O)CC2=CC=C(O)C=C2)=O)N)=CC=C1O—
31955-3AYA22335.1M3
1955-2;Phenylalanine
from: 1955-2
ClC1=CC([C@H](C(N[C@@H](C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)CC3=CC=C(O)C=C3)=O)N)=CC=C1O—
41955-4AYA22334.1M4
1955-3;L-β-hydroxytyrosine
from: 1955-3
ClC1=CC([C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(O)=O)C2=CC=C(O)C=C2)=O)CC3=CC=CC=C3)=O)CC4=CC=C(O)C=C4)=O)N)=CC=C1O—
51955-5AYA22334.1M5
1955-4;L-β-hydroxytyrosine
from: 1955-4
ClC1=CC([C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@@H](C(O)=O)C2=CC=C(O)C=C2)=O)C3=CC=C(O)C=C3)=O)CC4=CC=CC=C4)=O)CC5=CC=C(O)C=C5)=O)N)=CC=C1O—
61955-6AYA22334.1M6
1955-5;3-Chloro-L-Tyrosine
from: 1955-5
ClC1=CC([C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@@H](C(NC(C(O)=O)CC2=CC=C(O)C(Cl)=C2)=O)C3=CC=C(O)C=C3)=O)C4=CC=C(O)C=C4)=O)CC5=CC=CC=C5)=O)CC6=CC=C(O)C=C6)=O)N)=CC=C1O—
71955-7AYA22333.1M7
1955-6;L-3,5-dihydroxyphenylglycine
from: 1955-6
ClC1=CC([C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@@H](C(NC(C(NC(C(O)=O)C2=CC(O)=CC(O)=C2)=O)CC3=CC=C(O)C(Cl)=C3)=O)C4=CC=C(O)C=C4)=O)C5=CC=C(O)C=C5)=O)CC6=CC=CC=C6)=O)CC7=CC=C(O)C=C7)=O)N)=CC=C1O—
81955-8AYA22333.1TE
1955-7
from: 1955-7
ClC1=CC([C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(O)=O)C2=CC(O)=CC(O)=C2)=O)CC3=CC=C(O4)C(Cl)=C3)=O)C5=CC=C(O)C=C5)=O)C6=CC=C(O)C4=C6)=O)CC7=CC=CC=C7)=O)[C@H](O)C8=CC=C(O)C=C8)=O)N)=CC=C1O—
91955-9Start—
L-actinosamine
O[C@H]1C[C@H](N)[C@@H](OC)[C@H](C)O1—
101955-10Start—
D-Glucose
O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O—
111955-11Start—
L-Fucose
O[C@H]1[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O1—
121955-12Start—
O[C@H]1[C@H](O)[C@H](N)[C@@H](O)[C@H](C)O1—
131955-13Start—
Glucuronic acid
O[C@@H]1[C@@H](O)OC(C(O)=O)[C@@H](O)[C@@H]1O—
141955-14?—
1955-8;1955-9;1955-10
from: 1955-8, 1955-9, 1955-10
ClC1=CC([C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@@H](C(N[C@H]([C@@H](O[C@H]2C[C@H](N)[C@@H](OC)[C@H](C)O2)N[C@H](C(O)=O)C3=CC(O)=CC(O)=C3)CC4=CC=C(O5)C(Cl)=C4)=O)C6=CC=C(O)C=C6)=O)C7=CC=C(O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)C5=C7)=O)CC9=CC=CC=C9)=O)[C@H](O)C%10=CC=C(O)C=C%10)=O)N)=CC=C1O—
151955(1)?—
1955-14;1955-11;1955-13
from: 1955-14, 1955-11, 1955-13
ClC1=CC([C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@@H](C(N[C@H]([C@@H](O[C@H]2C[C@H](N)[C@@H](OC)[C@H](C)O2)N[C@H](C(O)=O)C3=CC(O)=CC(O[C@@H]4[C@@H](O)[C@@H](O)[C@H](O)C(C(O)=O)O4)=C3)CC5=CC=C(O6)C(Cl)=C5)=O)C7=CC=C(O)C=C7)=O)C8=CC=C(O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9O[C@H]%10[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O%10)C6=C8)=O)CC%11=CC=CC=C%11)=O)[C@H](O)C%12=CC=C(O)C=C%12)=O)N)=CC=C1O—
161955(2)?—
1955-14;1955-12
from: 1955-14, 1955-12
ClC1=CC([C@H](C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@@H](C(N[C@H]([C@@H](O[C@H]2C[C@H](N)[C@@H](OC)[C@H](C)O2)N[C@H](C(O)=O)C3=CC(O)=CC(O)=C3)CC4=CC=C(O5)C(Cl)=C4)=O)C6=CC=C(O)C=C6)=O)C7=CC=C(O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O[C@H]9[C@H](O)[C@H](N)[C@@H](O)[C@H](C)O9)C5=C7)=O)CC%10=CC=CC=C%10)=O)[C@H](O)C%11=CC=C(O)C=C%11)=O)N)=CC=C1O—
171955(3)?—
1955-14;1955-12;1955-13
from: 1955-14, 1955-12, 1955-13
ClC1=CC(C(C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@@H](C(N[C@H]([C@@H](O[C@H]2C[C@H](N)[C@@H](OC)[C@H](C)O2)N[C@H](C(O)=O)C3=CC(O)=CC(O[C@@H]4[C@@H](O)[C@@H](O)[C@H](O)C(C(O)=O)O4)=C3)CC5=CC=C(O6)C(Cl)=C5)=O)C7=CC=C(O)C=C7)=O)C8=CC=C(O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9O[C@H]%10[C@H](O)[C@H](N)[C@@H](O)[C@H](C)O%10)C6=C8)=O)CC%11=CC=CC=C%11)=O)[C@H](O)C%12=CC=C(O)C=C%12)=O)=O)=CC=C1O—
181955(4)?—
1955-14;1955-11;1955-13
from: 1955-14, 1955-11, 1955-13
ClC1=CC(C(C(N[C@@H](C(N[C@H](C(N[C@@H](C(N[C@@H](C(N[C@H]([C@@H](O[C@H]2C[C@H](N)[C@@H](OC)[C@H](C)O2)N[C@H](C(O)=O)C3=CC(O)=CC(O[C@@H]4[C@@H](O)[C@@H](O)[C@H](O)C(C(O)=O)O4)=C3)CC5=CC=C(O6)C(Cl)=C5)=O)C7=CC=C(O)C=C7)=O)C8=CC=C(O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9O[C@H]%10[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O%10)C6=C8)=O)CC%11=CC=CC=C%11)=O)[C@H](O)C%12=CC=C(O)C=C%12)=O)=O)=CC=C1O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture