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BGC0001944PKS

Funisamine

Producing organism
Streptosporangium sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Streptosporangiales›Streptosporangiaceae›Streptosporangium
Biosynthetic class
PKS (Unknown)
Total steps
37
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map40 genes · 165,922 bp

20 kb165.9 kb visible · 165,922 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
DHtDehydratase (DHt)
ACPSACP synthase

Pathway Graphsteps arranged in biosynthetic order

37 steps · 36 edges
Step 1
Start
+Arginine
Step 27
Start
+3-hydroxypentyl-C…
Step 2
AXI91557.1
Step 28
AXI91538.1
Step 3
?
Step 29
AXI91540.1
Step 4
AXI91564.1
Step 5
AXI91565.1
Step 6Load
AXI91552.1, AXI91566.1
Step 7M1
AXI91552.1
+Malonyl-CoA
Step 8M2
AXI91552.1
+Malonyl-CoA
Step 9M3
AXI91552.1
+Malonyl-CoA
Step 10M4
AXI91552.1
+Malonyl-CoA
Step 11M5
AXI91552.1
+Malonyl-CoA
Step 12M6
AXI91552.1
+Malonyl-CoA
Step 13M7
AXI91552.1
+Malonyl-CoA
Step 14M8
AXI91552.1
+Malonyl-CoA
Step 15M9
AXI91552.1
+Malonyl-CoA
Step 16M10
AXI91551.1
+Malonyl-CoA
Inactive: DH
Step 17M11
AXI91550.1
+Methylmalonyl-CoA
Step 18M12
AXI91550.1
+Methylmalonyl-CoA
Inactive: KR
Step 19M13
AXI91549.1
+Malonyl-CoA
Step 20M14
AXI91549.1
+Malonyl-CoA
Step 21M15
AXI91549.1
+Malonyl-CoA
Step 22M16
AXI91548.1
+Malonyl-CoA
Step 23M17
AXI91548.1
+Malonyl-CoA
Step 24M18
AXI91548.1
+Malonyl-CoA
Step 25M19
AXI91548.1
+Malonyl-CoA
Step 26M20
AXI91547.1
+Methylmalonyl-CoA
Step 30M21
AXI91547.1
Step 31M22
AXI91546.1
+Malonyl-CoA
Step 32M23
AXI91546.1
+Malonyl-CoA
Step 33M24
AXI91546.1
+Malonyl-CoA
Step 34M25
AXI91546.1
+Malonyl-CoA
Step 35M26
AXI91545.1
+Malonyl-CoA
Step 36TE
AXI91545.1
Step 37
AXI91543.1
+?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions37 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11944-1Start—
Arginine
N[C@@H](CCCNC(N)=N)C(O)=O—
21944-2AXI91557.1—
1944-1
from: 1944-1
NC(CCCNC(N)=N)N—
31944-3?—
1944-2
from: 1944-2
O=C(CCCNC(N)=N)[H]—
41944-4AXI91564.1—
1944-3
from: 1944-3
O=C(CCCNC(N)=N)[R]—
51944-5AXI91565.1—
1944-4
from: 1944-4
O=C(CCCN)[R]—
61944-6AXI91552.1, AXI91566.1Loading
1944-5
from: 1944-5
NCCCC(O)=O—
71944-7AXI91552.1M1
1944-6;Malonyl-CoA
from: 1944-6
NCCC[C@H](O)CC(O)=O—
81944-8AXI91552.1M2
1944-7;Malonyl-CoA
from: 1944-7
NCCC[C@H](O)C[C@H](O)CC(O)=O—
91944-9AXI91552.1M3
1944-8;Malonyl-CoA
from: 1944-8
NCCC[C@H](O)C[C@H](O)C[C@H](O)CC(O)=O—
101944-10AXI91552.1M4
1944-9;Malonyl-CoA
from: 1944-9
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)CC(O)=O—
111944-11AXI91552.1M5
1944-10;Malonyl-CoA
from: 1944-10
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)CC(O)=O—
121944-12AXI91552.1M6
1944-11;Malonyl-CoA
from: 1944-11
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)CC(O)=O—
131944-13AXI91552.1M7
1944-12;Malonyl-CoA
from: 1944-12
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](CC(O)=O)O—
141944-14AXI91552.1M8
1944-13;Malonyl-CoA
from: 1944-13
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](CC(O)=O)O)O—
151944-15AXI91552.1M9
1944-14;Malonyl-CoA
from: 1944-14
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/C(O)=O)O)O—
161944-16AXI91551.1M10
1944-15;Malonyl-CoA
from: 1944-15
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](CC(O)=O)O)O)O{'Inactive': ['DH']}
171944-17AXI91550.1M11
1944-16;Methylmalonyl-CoA
from: 1944-16
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](C[C@@H]([C@@H](C(O)=O)C)O)O)O)O—
181944-18AXI91550.1M12
1944-17;Methylmalonyl-CoA
from: 1944-17
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](C[C@@H]([C@@H](C([C@@H](C(O)=O)C)=O)C)O)O)O)O{'Inactive': ['KR']}
191944-19AXI91549.1M13
1944-18;Malonyl-CoA
from: 1944-18
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](C[C@@H]([C@@H](C([C@@H]([C@@H](CC(O)=O)O)C)=O)C)O)O)O)O—
201944-20AXI91549.1M14
1944-19;Malonyl-CoA
from: 1944-19
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](C[C@@H]([C@@H](C([C@@H]([C@@H](C/C=C/C(O)=O)O)C)=O)C)O)O)O)O—
211944-21AXI91549.1M15
1944-20;Malonyl-CoA
from: 1944-20
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](C[C@@H]([C@@H](C([C@@H]([C@@H](C/C=C/C=C/C(O)=O)O)C)=O)C)O)O)O)O—
221944-22AXI91548.1M16
1944-21;Malonyl-CoA
from: 1944-21
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](C[C@@H]([C@@H](C([C@@H]([C@@H](C/C=C/C=C/C=C/C(O)=O)O)C)=O)C)O)O)O)O—
231944-23AXI91548.1M17
1944-22;Malonyl-CoA
from: 1944-22
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](C[C@@H]([C@@H](C([C@@H]([C@@H](C/C=C/C=C/C=C/C=C/C(O)=O)O)C)=O)C)O)O)O)O—
241944-24AXI91548.1M18
1944-23;Malonyl-CoA
from: 1944-23
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](C[C@@H]([C@@H](C([C@@H]([C@@H](C/C=C/C=C/C=C/C=C/C=C/C(O)=O)O)C)=O)C)O)O)O)O—
251944-25AXI91548.1M19
1944-24;Malonyl-CoA
from: 1944-24
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](C[C@@H]([C@@H](C([C@@H]([C@@H](C/C=C/C=C/C=C/C=C/C=C/C=C/C(O)=O)O)C)=O)C)O)O)O)O—
261944-26AXI91547.1M20
1944-25;Methylmalonyl-CoA
from: 1944-25
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](C[C@@H]([C@@H](C([C@@H]([C@@H](C/C=C/C=C/C=C/C=C/C=C/C=C/C=C(C)/C(O)=O)O)C)=O)C)O)O)O)O—
271944-27Start—
3-hydroxypentyl-CoA
O=C(CC(CC)O)[R]—
281944-28AXI91538.1—
1944-27
from: 1944-27
O=C(/C=C/CC)[R]—
291944-29AXI91540.1—
1944-28
from: 1944-28
O=C(C(C(O)=O)CCC)[R]—
301944-30AXI91547.1M21
1944-26;1944-29
from: 1944-26, 1944-29
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](C[C@@H]([C@@H](C([C@@H]([C@@H](C/C=C/C=C/C=C/C=C/C=C/C=C/C=C(C)/[C@H](O)[C@H](CCC)C(O)=O)O)C)=O)C)O)O)O)O—
311944-31AXI91546.1M22
1944-30;Malonyl-CoA
from: 1944-30
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](C[C@@H]([C@@H](C([C@@H]([C@@H](C/C=C/C=C/C=C/C=C/C=C/C=C/C=C(C)/[C@H](O)[C@H](CCC)CCC(O)=O)O)C)=O)C)O)O)O)O—
321944-32AXI91546.1M23
1944-31;Malonyl-CoA
from: 1944-31
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](C[C@@H]([C@@H](C([C@@H]([C@@H](C/C=C/C=C/C=C/C=C/C=C/C=C/C=C(C)/[C@H](O)[C@H](CCC)CC/C=C/C(O)=O)O)C)=O)C)O)O)O)O—
331944-33AXI91546.1M24
1944-32;Malonyl-CoA
from: 1944-32
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](C[C@@H]([C@@H](C([C@@H]([C@@H](C/C=C/C=C/C=C/C=C/C=C/C=C/C=C(C)/[C@H](O)[C@H](CCC)CC/C=C/C=C/C(O)=O)O)C)=O)C)O)O)O)O—
341944-34AXI91546.1M25
1944-33;Malonyl-CoA
from: 1944-33
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](C[C@@H]([C@@H](C([C@@H]([C@@H](C/C=C/C=C/C=C/C=C/C=C/C=C/C=C(C)/[C@H](O)[C@H](CCC)CC/C=C/C=C/C=C/C(O)=O)O)C)=O)C)O)O)O)O—
351944-35AXI91545.1M26
1944-34;Malonyl-CoA
from: 1944-34
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](C[C@@H]([C@@H](C([C@@H]([C@@H](C/C=C/C=C/C=C/C=C/C=C/C=C/C=C(C)/[C@H](O)[C@H](CCC)CC/C=C/C=C/C=C/C=C/C(O)=O)O)C)=O)C)O)O)O)O—
361944-36AXI91545.1TE
1944-35
from: 1944-35
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](C[C@@H]([C@@H](C([C@@H]([C@@H](C/C=C/C=C/C=C/C=C/C=C/C=C/C=C(C)/[C@H](O)[C@H](CCC)CC/C=C/C=C/C=C/C=C/C(O)=O)O)C)=O)C)O)O)O)O—
371944AXI91543.1—
1944-36;?
from: 1944-36
NCCC[C@H](O)C[C@H](O)C[C@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@@H](C[C@@H](C/C=C/[C@@H](C[C@@H]([C@@H](C([C@@H]([C@@H](C/C=C/C=C/C=C/C=C/C=C/C=C/C=C(C)/[C@H](O)[C@H](CCC)CC/C=C/C=C/C=C/C=C/C(O)=O)OS(=O)(O)=O)C)=O)C)O)O)O)O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture