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BGC0001918Hybrid

JBIR-06

Producing organism
Streptomyces sp
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
6
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map18 genes · 32,523 bp

CACCALKRCCALKRKSATMTTETEAAmTAmT5 kb32.5 kb visible · 32,523 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
MTMethyltransferase
ACPSACP synthase
CALCoA-ligase (CAL)
AmTAminotransferase IV
AmTAminotransferase V

Pathway Graphsteps arranged in biosynthetic order

6 steps · 5 edges
Step 1Load
smlF;smlG
+3-formamidosalicy…
Step 2M1
smlB
+L-Threonine
Step 3M2
smlB
+Isoleucic acid
Step 4M3
smlB
+Leucic acid
Step 5M4
smlC
+Methylmalonyl-CoA
Step 6TE
smlC
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions6 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11918-1smlF;smlGLoading
3-formamidosalicylate
OC(C1=CC=CC(NC([H])=O)=C1O)=O—
21918-2smlBM1
1918-1;L-Threonine
from: 1918-1
O=C(C1=CC=CC(NC([H])=O)=C1O)N[C@H](C(O)=O)[C@@H](C)O—
31918-3smlBM2
1918-2;Isoleucic acid
from: 1918-2
O[C@H](C)[C@@H](C(O[C@H](C(O)=O)[C@@H](CC)C)=O)NC(C1=CC=CC(NC([H])=O)=C1O)=O—
41918-4smlBM3
1918-3;Leucic acid
from: 1918-3
O[C@H](C)[C@@H](C(O[C@H](C(O[C@H](C(O)=O)CC(C)C)=O)[C@@H](CC)C)=O)NC(C1=CC=CC(NC([H])=O)=C1O)=O—
51918-5smlCM4
1918-4;Methylmalonyl-CoA
from: 1918-4
O[C@H](C)[C@@H](C(O[C@H](C(O[C@H](C(C(C)(C)C(O)=O)=O)CC(C)C)=O)[C@@H](CC)C)=O)NC(C1=CC=CC(NC([H])=O)=C1O)=O—
61918smlCTE
1918-5
from: 1918-5
O=C(O[C@@H]([C@H](CC)C)C(O[C@@H](CC(C)C)C1=O)=O)[C@@H](NC(C2=CC=CC(NC([H])=O)=C2O)=O)[C@@H](C)OC(C1(C)C)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture