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BGC0001885Hybrid

Oxazolepoxidomycin A

Producing organism
Streptomyces sp. NRRL F-4335
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
14
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map15 genes · 83,425 bp

KSKSKSKSAKSKSAKSKSKSKSKSKSA20 kb83.4 kb visible · 83,425 bp total
Biosynthetic (core)
Biosynthetic (additional)
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TdTrans-AT docking
DH2Dehydratase (DH2)
MTMethyltransferase
ACPSACP synthase

Pathway Graphsteps arranged in biosynthetic order

14 steps · 13 edges
Step 1M1
ozeD
Inactive: ozeJ, Malonyl-CoA
Step 2M2
ozeF
Inactive: ozeJ, Malonyl-CoA
Step 3M3
ozeA
Inactive: ozeJ, Malonyl-CoA
Step 4M4
ozeB
Inactive: ozeJ, Malonyl-CoA
Step 5M5
ozeC
Inactive: ozeJ, Malonyl-CoA
Step 6M6
ozeC
Inactive: ozeJ, Malonyl-CoA
Step 7M7
ozeG
Inactive: ozeJ, Malonyl-CoA
Step 8M8
ozeG
+Glycine
Step 9M9
ozeG
Inactive: ozeJ, Malonyl-CoA
Step 10M10;11
ozeG
Inactive: ozeJ, Malonyl-CoA
Step 11M12;13
ozeG;ozeH;ozeM
Inactive: ozeJ, Malonyl-CoA
Step 12M14
ozeH
Inactive: ozeJ, Malonyl-CoA
Step 13M15
ozeI
+Serine
Step 14
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions14 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11885-1ozeDM1
O=C(O)CNC([H])=O{'transAT': ['ozeJ', 'Malony…
21885-2ozeFM2
1885-1
from: 1885-1
O=C(CC(O)=O)CNC([H])=O{'transAT': ['ozeJ', 'Malony…
31885-3ozeAM3
1885-2
from: 1885-2
OC(C/C=C/C1=CN=CO1)=O{'transAT': ['ozeJ', 'Malony…
41885-4ozeBM4
1885-3
from: 1885-3
OC(C/C=C/C=C/C1=CN=CO1)=O{'transAT': ['ozeJ', 'Malony…
51885-5ozeCM5
1885-4
from: 1885-4
OC(C/C=C/C=C/C=C/C1=CN=CO1)=O{'transAT': ['ozeJ', 'Malony…
61885-6ozeCM6
1885-5
from: 1885-5
O=C(O)/C(C)=C/C/C=C/C=C/C=C/C1=CN=CO1{'transAT': ['ozeJ', 'Malony…
71885-7ozeGM7
1885-6
from: 1885-6
O[C@@H](C(C)(C)C(O)=O)/C(C)=C/C/C=C/C=C/C=C/C1=CN=CO1{'transAT': ['ozeJ', 'Malony…
81885-8ozeGM8
1885-7;Glycine
from: 1885-7
O[C@@H](C(C)(C)C(NCC(O)=O)=O)/C(C)=C/C/C=C/C=C/C=C/C1=CN=CO1—
91885-9ozeGM9
1885-8
from: 1885-8
O[C@@H](C(C)(C)C(NCC(O)CC(O)=O)=O)/C(C)=C/C/C=C/C=C/C=C/C1=CN=CO1{'transAT': ['ozeJ', 'Malony…
101885-10ozeGM10;11
1885-9
from: 1885-9
O[C@@H](C(C)(C)C(NCC(O)/C=C/C(C)(C)C(O)=O)=O)/C(C)=C/C/C=C/C=C/C=C/C1=CN=CO1{'transAT': ['ozeJ', 'Malony…
111885-11ozeG;ozeH;ozeMM12;13
1885-10
from: 1885-10
O[C@@H](C(C)(C)C(NCC(O)/C=C/C(C)(C)CC(C(O)=O)C)=O)/C(C)=C/C/C=C/C=C/C=C/C1=CN=CO1{'transAT': ['ozeJ', 'Malony…
121885-12ozeHM14
1885-11
from: 1885-11
O[C@@H](C(C)(C)C(NCC(O)/C=C/C(C)(C)CC(C([C@H](C(O)=O)C)=O)C)=O)/C(C)=C/C/C=C/C=C/C=C/C1=CN=CO1{'transAT': ['ozeJ', 'Malony…
131885-13ozeIM15
1885-12;Serine
from: 1885-12
O[C@@H](C(C)(C)C(NCC(O)/C=C/C(C)(C)CC(C([C@H](C(N(C(C(O)=O)CO)C)=O)C)=O)C)=O)/C(C)=C/C/C=C/C=C/C=C/C1=CN=CO1—
141885?—
1885-13
from: 1885-13
O=C(NCC(C1C(C(CC(C2(O)C(C)(C)C(N(C)[C@]23C(OC3)=O)=O)C)O)O1)O)C(C)(C(O)/C(C)=C\C/C=C/C=C/C=C/C4=CN=CO4)C—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture