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BGC0001877PKS

Cyphomycin

Producing organism: Streptomyces sp. ISID311
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: PKS (Unknown)
Total steps: 23
DOI: 10.3390/biology11111676 10.1039/C8OB03115K
MIBiG entry: View on MIBiG ↗

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cyphomycin

C₇₇H₁₂₂O₂₆1462.82 Da

Gene Cluster Map72 genes · 194,339 bp

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Transport

Other

Unknown

Domains

Ketosynthase (KS)

Acyltransferase (AT)

Dehydratase (DH)

Enoylreductase (ER)

Ketoreductase (KR)

Acyl carrier protein (ACP)

Acyl carrier (ACP)

Adenylation (A)

Peptidyl carrier (PCP)

Thioesterase (TE)

Docking N-term

Docking C-term

ACP synthase

CoA-ligase (CAL)

NAD-binding

Pathway Graphsteps arranged in biosynthetic order

23 steps · 22 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions23 steps

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`1877-1`	FS847_02035	Loading	Methylmalonyl-CoA	`O=C(CC)O`	—
2	`1877-2`	FS847_02035	M1	1877-1;Methylmalonyl-CoA from: 1877-1	`O[C@@H](CC)[C@H](C)C(O)=O`	—
3	`1877-3`	FS847_02035	M2	1877-2;Methylmalonyl-CoA from: 1877-2	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)C(O)=O`	—
4	`1877-4`	FS847_02030	M3	1877-3;Methylmalonyl-CoA from: 1877-3	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)C(O)=O`	—
5	`1877-5`	FS847_02030	M4	1877-4;Methylmalonyl-CoA from: 1877-4	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)C(O)=O`	—
6	`1877-6`	FS847_02030	M5	1877-5;Malonyl-CoA from: 1877-5	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C(O)=O`	—
7	`1877-7`	FS847_01995	M6	1877-6;Malonyl-CoA from: 1877-6	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CC(O)=O`	{'Inactive': ['DH']}
8	`1877-8`	FS847_01995	M7	1877-7;Malonyl-CoA from: 1877-7	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCCC(O)=O`	—
9	`1877-9`	FS847_01990	M8	1877-8;Malonyl-CoA from: 1877-8	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CC(O)=O`	—
10	`1877-10`	FS847_01990	M9	1877-9;Malonyl-CoA from: 1877-9	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCCC(O)=O`	—
11	`1877-11`	FS847_01990	M10	1877-10;Malonyl-CoA from: 1877-10	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)CC(O)=O`	—
12	`1877-12`	?	M11	1877-11;Malonyl-CoA from: 1877-11	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)CC(O)=O`	—
13	`1877-13`	?	M12	1877-12;Malonyl-CoA from: 1877-12	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)C[C@H](O)CC(O)=O`	—
14	`1877-14`	?	M13	1877-13;Malonyl-CoA from: 1877-13	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)C[C@H](O)CC(CC(O)=O)=O`	{'Inactive': ['DH']}
15	`1877-15`	FS847_01965	M14	1877-14;Methylmalonyl-CoA from: 1877-14	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)C[C@H](O)CC(C[C@@H](O)[C@@H](C(O)=O)C)=O`	—
16	`1877-16`	FS847_01965	M15	1877-15;Malonyl-CoA from: 1877-15	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)C[C@H](O)CC(C[C@@H](O)[C@@H](CCC(O)=O)C)=O`	—
17	`1877-17`	FS847_01960	M16	1877-16;Malonyl-CoA from: 1877-16	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)C[C@H](O)CC(C[C@@H](O)[C@@H](CC[C@H](O)CC(O)=O)C)=O`	—
18	`1877-18`	FS847_01960	M17	1877-17;Malonyl-CoA from: 1877-17	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)C[C@H](O)CC(C[C@@H](O)[C@@H](CC[C@H](O)CCCC(O)=O)C)=O`	—
19	`1877-19`	FS847_01960	M18	1877-18;Malonyl-CoA from: 1877-18	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)C[C@H](O)CC(C[C@@H](O)[C@@H](CC[C@H](O)CCC[C@@H](O)CC(O)=O)C)=O`	—
20	`1877-20`	FS847_01955	M19	1877-19;Methylmalonyl-CoA from: 1877-19	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)C[C@H](O)CC(C[C@@H](O)[C@@H](CC[C@H](O)CCC[C@@H](O)C[C@@H](O)[C@H](C(O)=O)C)C)=O`	—
21	`1877-21`	FS847_01955	M20	1877-20;Malonyl-CoA from: 1877-20	`O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)C[C@H](O)CC(C[C@@H](O)[C@@H](CC[C@H](O)CCC[C@@H](O)C[C@@H](O)[C@H](/C=C/C(O)=O)C)C)=O`	—
22	`1877-22`	FS847_01955	TE	1877-21 from: 1877-21	`O[C@H](CCC[C@@H](/C=C/[C@H](C)[C@@H]([C@H]([C@H]([C@@H]([C@H]([C@H]([C@@H](O)CC)C)O)C)O)C)O1)O)CCC[C@H](O)C[C@H]2O[C@](C[C@@H]([R])[C@H](C)CC[C@H](O)CCC[C@@H](O)C[C@@H](O)[C@@H](C)/C=C/C1=O)(O)C[C@@H](O)C2`	—
23	`1877`	?	—	1877-22;? from: 1877-22	`O[C@H](CCC[C@@H](/C=C/[C@H](C)[C@@H]([C@H]([C@H]([C@@H]([C@H]([C@H]([C@@H](O[C@@H]1O[C@@H](C)[C@@H](O[C@H]2CC[C@H](OC([C@@H]([C@@H](C3=CC=C(C(C(C)=CC4=O)=O)C4=C3)O)C)=O)[C@@H](C)O2)[C@](C)(O)C1)CC)C)O)C)O)C)O5)O)C[C@@H](O)C[C@H](O)C[C@H]6O[C@](C([C@@H](O)[C@H](C)CC[C@H](O)CCC[C@@H](O)C[C@@H](O)[C@@H](C)/C=C/C5=O)=O)(O)C[C@@H](O)C6`	—

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