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BGC0001856PKS

Caniferolide A;Caniferolide B;Caniferolide C;Caniferolide D

Producing organism
Streptomyces caniferus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Type I)
Total steps
26
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map62 genes · 186,923 bp

50 kb186.9 kb visible · 186,923 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
DHtDehydratase (DHt)
CALCoA-ligase (CAL)
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

26 steps · 25 edges
Step 1Load
scaP1
+Methylmalonyl-CoA
Step 2M1
scaP1
+Methylmalonyl-CoA
Step 3M2
scaP1
+Methylmalonyl-CoA
Step 4M3
scaP2
+Methylmalonyl-CoA
Step 5M4
scaP2
+Methylmalonyl-CoA
Step 6M5
scaP2
+Malonyl-CoA
Step 7M6
scaP3
+Malonyl-CoA
Inactive: DH
Step 8M7
scaP3
+Malonyl-CoA
Step 9M8
scaP4
+Malonyl-CoA
Step 10M9
scaP4
+Malonyl-CoA
Step 11M10
scaP4
+Malonyl-CoA
Step 12M11
scaP5
+Malonyl-CoA
Step 13M12
scaP5
+Malonyl-CoA
Step 14M13
scaP5
+Malonyl-CoA
Inactive: DH
Step 15M14
scaP5
+Methylmalonyl-CoA
Step 16M15
scaP5
+Malonyl-CoA
Step 17M16
scaP6
+Malonyl-CoA
Step 18M17
scaP6
+Malonyl-CoA
Step 19M18
scaP6
+Malonyl-CoA
Step 20M19
scaP7
+Methylmalonyl-CoA
Step 21M20
scaP7
+Malonyl-CoA
Step 22TE
scaP7
Step 23
?
+?
Step 24
?
+?
Step 25
?
+?
Step 26
?
+?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions26 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11856-1scaP1Loading
Methylmalonyl-CoA
O=C(CC)O—
21856-2scaP1M1
1856-1;Methylmalonyl-CoA
from: 1856-1
O[C@@H](CC)[C@H](C)C(O)=O—
31856-3scaP1M2
1856-2;Methylmalonyl-CoA
from: 1856-2
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)C(O)=O—
41856-4scaP2M3
1856-3;Methylmalonyl-CoA
from: 1856-3
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)C(O)=O—
51856-5scaP2M4
1856-4;Methylmalonyl-CoA
from: 1856-4
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)C(O)=O—
61856-6scaP2M5
1856-5;Malonyl-CoA
from: 1856-5
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C(O)=O—
71856-7scaP3M6
1856-6;Malonyl-CoA
from: 1856-6
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CC(O)=O{'Inactive': ['DH']}
81856-8scaP3M7
1856-7;Malonyl-CoA
from: 1856-7
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCCC(O)=O—
91856-9scaP4M8
1856-8;Malonyl-CoA
from: 1856-8
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CC(O)=O—
101856-10scaP4M9
1856-9;Malonyl-CoA
from: 1856-9
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCCC(O)=O—
111856-11scaP4M10
1856-10;Malonyl-CoA
from: 1856-10
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)CC(O)=O—
121856-12scaP5M11
1856-11;Malonyl-CoA
from: 1856-11
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)CC(O)=O—
131856-13scaP5M12
1856-12;Malonyl-CoA
from: 1856-12
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)C[C@H](O)CC(O)=O—
141856-14scaP5M13
1856-13;Malonyl-CoA
from: 1856-13
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)C[C@H](O)CC(CC(O)=O)=O{'Inactive': ['DH']}
151856-15scaP5M14
1856-14;Methylmalonyl-CoA
from: 1856-14
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)C[C@H](O)CC(C[C@@H](O)[C@@H](C(O)=O)C)=O—
161856-16scaP5M15
1856-15;Malonyl-CoA
from: 1856-15
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)C[C@H](O)CC(C[C@@H](O)[C@@H](CCC(O)=O)C)=O—
171856-17scaP6M16
1856-16;Malonyl-CoA
from: 1856-16
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)C[C@H](O)CC(C[C@@H](O)[C@@H](CC[C@H](O)CC(O)=O)C)=O—
181856-18scaP6M17
1856-17;Malonyl-CoA
from: 1856-17
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)C[C@H](O)CC(C[C@@H](O)[C@@H](CC[C@H](O)CCCC(O)=O)C)=O—
191856-19scaP6M18
1856-18;Malonyl-CoA
from: 1856-18
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)C[C@H](O)CC(C[C@@H](O)[C@@H](CC[C@H](O)CCC[C@@H](O)CC(O)=O)C)=O—
201856-20scaP7M19
1856-19;Methylmalonyl-CoA
from: 1856-19
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)C[C@H](O)CC(C[C@@H](O)[C@@H](CC[C@H](O)CCC[C@@H](O)C[C@@H](O)[C@H](C(O)=O)C)C)=O—
211856-21scaP7M20
1856-20;Malonyl-CoA
from: 1856-20
O[C@@H](CC)[C@H](C)[C@H](O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/[C@@H](O)CCC[C@@H](O)CCC[C@H](O)C[C@@H](O)C[C@H](O)CC(C[C@@H](O)[C@@H](CC[C@H](O)CCC[C@@H](O)C[C@@H](O)[C@H](/C=C/C(O)=O)C)C)=O—
221856-22scaP7TE
1856-21
from: 1856-21
O[C@H](CCC[C@@H](/C=C/[C@H](C)[C@@H]([C@H]([C@H]([C@@H]([C@H]([C@H]([C@@H](O)CC)C)O)C)O)C)O1)O)CCC[C@H](O)C[C@H]2O[C@](C[C@@H]([R])[C@H](C)CC[C@H](O)CCC[C@@H](O)C[C@@H](O)[C@@H](C)/C=C/C1=O)(O)C[C@@H](O)C2—
231856(1)?—
1856-22;?
from: 1856-22
O[C@H](CCC[C@@H]([C@H](O1)[C@@H]1[C@H](C)[C@@H]([C@H]([C@H]([C@@H]([C@H]([C@H]([C@@H](O[C@@H]2O[C@@H](C)[C@@H](O[C@H]3CC[C@H](OC([C@@H]([C@@H](C4=CC=C(C(C(C)=CC5=O)=O)C5=C4)O)C)=O)[C@@H](C)O3)[C@](C)(O)C2)CC)C)O)C)O)C)O6)O)C[C@@H](O)C[C@H](O)C[C@H]7O[C@](C([C@@H](O)[C@H](C)CC[C@H](O)CCC[C@@H](O)C[C@@H](O)[C@@H](C)/C=C/C6=O)=O)(O)[C@H](O)[C@@H](OS(O)(=O)=O)C7—
241856(2)?—
1856-22;?
from: 1856-22
O[C@H](CCC[C@@H]([C@H](O1)[C@@H]1[C@H](C)[C@@H]([C@H]([C@H]([C@@H]([C@H]([C@H]([C@@H](O[C@@H]2O[C@@H](C)[C@@H](O[C@H]3CC[C@H](OC([C@@H]([C@@H](C4=CC=C(C(C(C)=CC5=O)=O)C5=C4)O)C)=O)[C@@H](C)O3)[C@](C)(O)C2)CC)C)O)C)O)C)O6)O)C[C@@H](O)C[C@H](O)C[C@H]7O[C@](C([C@@H](O)[C@H](C)CC[C@H](O)CCC[C@@H](O)C[C@@H](O)[C@@H](C)/C=C/C6=O)=O)(O)[C@H](O)[C@@H](O)C7—
251856(3)?—
1856-22;?
from: 1856-22
O[C@H](CCC[C@@H]([C@H](O1)[C@@H]1[C@H](C)[C@@H]([C@H]([C@H]([C@@H]([C@H]([C@H]([C@@H](O[C@@H]2O[C@@H](C)[C@@H](O[C@H]3CC[C@H](OC([C@@H]([C@@H](C4=CC=C(C(C(C)=CC5=O)=O)C5=C4)O)C)=O)[C@@H](C)O3)[C@](C)(O)C2)CC)C)O)C)O)C)O6)O)C[C@@H](O)C[C@H](O)C[C@H]7O[C@](C([C@@H](O)[C@H](C)CC[C@H](O)CCC[C@@H](O)C[C@@H](O)[C@@H](C)/C=C/C6=O)=O)(O)C([H])[C@@H](O)C7—
261856(4)?—
1856-22;?
from: 1856-22
O[C@H](CCC[C@@H]([C@H](O1)[C@@H]1[C@H](C)[C@@H]([C@H]([C@H]([C@@H]([C@H]([C@H]([C@@H](O[C@@H]2O[C@@H](C)[C@@H](O[C@H]3CC[C@H](OC([C@@H]([C@@H](C4=CC=C(C(C(C)=CC5=O)=O)C5=C4)O)C)=O)[C@@H](C)O3)[C@](C)(O)C2)CC)C)O)C)O)C)O6)O)C[C@@H](O)C[C@H](O)C[C@H]7O[C@](C(C([H])[C@H](C)CC[C@H](O)CCC[C@@H](O)C[C@@H](O)[C@@H](C)/C=C/C6=O)=O)(O)[C@H](O)[C@@H](OS(O)(=O)=O)C7—
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