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BGC0001840Hybrid

Detoxin S1

Producing organism
Streptomyces sp. NRRL S-325
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
5
DOI
MIBiG entry
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detoxin S1
C28H43N3O6517.32 Da

Gene Cluster Map9 genes · 21,472 bp

ECHTauDACAKSKRTECATE5 kb21.5 kb visible · 21,472 bp total
Biosynthetic (core)
Biosynthetic (additional)
Unknown
Domains
KSKetosynthase (KS)
KRKetoreductase (KR)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
ECHEnoyl-CoA hydratase
TauDTauD oxygenase

Pathway Graphsteps arranged in biosynthetic order

5 steps · 4 edges
Step 1
ctg16_19
+Isoleucine
Step 4
ctg16_20
Step 2
ctg16_19
+Cysteine
Step 3
ctg16_19
+Malonyl-CoA
Step 5
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions5 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11840-1ctg16_19—
Isoleucine
N[C@@H]([C@@H](C)CC)C(O)=O—
21840-2ctg16_19—
1840-1;Cysteine
from: 1840-1
O=C(O)[C@H]1N(C([C@@H](N)C(C)C)=O)CCC1—
31840-3ctg16_19—
1840-2;Malonyl-CoA
from: 1840-2
O[C@@H](CC(O)=O)[C@H]1N(C([C@@H](N)C(C)C)=O)CCC1—
41840-4ctg16_20—
O=C(CCCCCC)N[C@H](C(O)=O)CC1=CC=CC=C1—
51840?—
1840-3;1840-4
from: 1840-3, 1840-4
O=C(CCCCCC)N[C@H](C(O[C@@H](CC(O)=O)[C@H]1N(C([C@@H](N)C(C)C)=O)CCC1)=O)CC2=CC=CC=C2—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture