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BGC0001830PKS

Rosamicin;Salinipyrone A;Pacificanone A

Producing organism
Salinispora mooreana
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Salinispora
Biosynthetic class
PKS (Unknown)
Total steps
18
DOI
MIBiG entry
View on MIBiG ↗
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C31H51NO9581.36 Da

Gene Cluster Map23 genes · 64,171 bp

KSKSKSKSATKSKSERKSKS10 kb64.2 kb visible · 64,171 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Resistance
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
DHtDehydratase (DHt)
AmTAminotransferase I/II
NADNAD-binding

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1M1
spr7
+Methylmalonyl-CoA
Step 17
Start
Step 2M2
spr7
+Methylmalonyl-CoA
Step 3M3
spr7
+Methylmalonyl-CoA
Step 4M4
spr8
+Malonyl-CoA
Step 5M5
spr9
+Methylmalonyl-CoA
Inactive: KR
Step 6M6
spr9
+Ethylmalonyl-CoA
Step 10M7
spr10
+Methylmalonyl-CoA
Inactive: KR
Step 7M7
spr10
+Methylmalonyl-CoA
Step 11
?
Step 13M7
spr10
+Methylmalonyl-CoA
Inactive: KR
Step 8M8
spr11
+Malonyl-CoA
Step 12
?
Step 14
?
Step 9TE
spr11
Step 15
?
Step 16
?
Step 18
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11830-1spr7M1
Methylmalonyl-CoA
O=C(O)CC—
21830-2spr7M2
1830-1;Methylmalonyl-CoA
from: 1830-1
O[C@@H]([C@@H](C)C(O)=O)CC—
31830-3spr7M3
1830-2;Methylmalonyl-CoA
from: 1830-2
O[C@@H]([C@@H](C)/C=C(C)/C(O)=O)CC—
41830-4spr8M4
1830-3;Malonyl-CoA
from: 1830-3
O[C@@H]([C@@H](C)/C=C(C)/C=C/C(O)=O)CC—
51830-5spr9M5
1830-4;Methylmalonyl-CoA
from: 1830-4
O[C@@H]([C@@H](C)/C=C(C)/C=C/C([C@H](C)C(O)=O)=O)CC{'Inactive': ['KR']}
61830-6spr9M6
1830-5;Ethylmalonyl-CoA
from: 1830-5
O[C@@H]([C@@H](C)/C=C(C)/C=C/C([C@H](C)C[C@H](CC)C(O)=O)=O)CC—
71830-7spr10M7
1830-6;Methylmalonyl-CoA
from: 1830-6
O[C@@H]([C@@H](C)/C=C(C)/C=C/C([C@H](C)C[C@H](CC)[C@H](O)[C@@H](C)C(O)=O)=O)CC—
81830-8spr11M8
1830-7;Malonyl-CoA
from: 1830-7
O[C@@H]([C@@H](C)/C=C(C)/C=C/C([C@H](C)C[C@H](CC)[C@H](O)[C@@H](C)[C@H](O)CC(O)=O)=O)CC—
91830-9spr11TE
1830-8
from: 1830-8
O=C1O[C@H](CC)[C@@H](C)/C=C(C)/C=C/C([C@H](C)C[C@H](CC)[C@H](O)[C@@H](C)[C@H](O)C1)=O—
101830-10spr10M7
1830-5;Methylmalonyl-CoA
from: 1830-5
O[C@@H]([C@@H](C)/C=C(C)/C=C/C([C@H](C)C([C@H](C(O)=O)C)=O)=O)CC{'Inactive': ['KR']}
111830-11?—
1830-10
from: 1830-10
O[C@@H]([C@@H](C)/C=C(C)/C=C/C([O-])=C(C)/C([C@H](C)C(O)=O)=O)CC—
121830(1)?—
1830-11
from: 1830-11
O[C@@H]([C@@H](C)/C=C(C)/C=C/C(O1)=C(C)C(O)=C(C)C1=O)CC—
131830-12spr10M7
1830-6;Methylmalonyl-CoA
from: 1830-6
O[C@@H]([C@@H](C)/C=C(C)/C=C/C([C@H](C)C[C@H](CC)C([C@@H](C)C(O)=O)=O)=O)CC{'Inactive': ['KR']}
141830-13?—
1830-12
from: 1830-12
O[C@@H]([C@@H](C)/C=C(C)/C=C/C([C@H](C)C[C@H](CC)C([C@@H](C)C(O)=O)=O)=O)CC—
151830-14?—
1830-13
from: 1830-13
O[C@@H]([C@@H](C)/C=C(C)/C=C/C([C@H](C)C[C@H](CC)C([C@@H](C)C(O)=O)=O)=O)CC—
161830(2)?—
1830-14
from: 1830-14
O[C@@H]([C@@H](C)/C=C(C)/C=C/[C@@]([C@@H]1C)(O)[C@H](C)C[C@H](CC)C1=O)CC—
171830-15Start—
O[C@@H]1O[C@H](C)C[C@H](N(C)C)[C@H]1O—
181830(3)?—
1830-9;1830-15
from: 1830-9, 1830-15
O=C1O[C@H](CC)[C@@H](C)/C=C(C)/C=C/C([C@H](C)C[C@H](CC)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](O)C1)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture