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BGC0001828PKS

Griseochelin

Producing organism
Streptomyces griseus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
14
DOI
MIBiG entry
View on MIBiG ↗
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griseochelin
C33H60O7568.43 Da

Gene Cluster Map13 genes · 74,735 bp

KSKSKSKSKSKSKSKSKSKSKSKSKS10 kb74.7 kb visible · 74,735 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term

Pathway Graphsteps arranged in biosynthetic order

14 steps · 13 edges
Step 1M1
zinA
+Methylmalonyl-CoA
Step 2M2
zinA
+Methylmalonyl-CoA
Step 3M3
zinB
+Methylmalonyl-CoA
Step 4M4
zinB
+Methylmalonyl-CoA
Step 5M5
zinB
Step 6M6
zinC
Step 7M7
zinD
+Methylmalonyl-CoA
Step 8M8
zinD
+Methylmalonyl-CoA
Step 9M9
zinE
+Methylmalonyl-CoA
Step 10M10
zinF
+Methylmalonyl-CoA
Step 11M11
zinF
Step 12M12
zinG
+Methylmalonyl-CoA
Step 13
zinH
Step 14
zinJ?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions14 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11828-1zinAM1
Methylmalonyl-CoA
O=C(CC)O—
21828-2zinAM2
1828-1;Methylmalonyl-CoA
from: 1828-1
CCCC(C(O)=O)C—
31828-3zinBM3
1828-2;Methylmalonyl-CoA
from: 1828-2
CCCC(/C=C(C(O)=O)\C)C—
41828-4zinBM4
1828-3;Methylmalonyl-CoA
from: 1828-3
CCCC(/C=C(C(O)C(C(O)=O)C)\C)C—
51828-5zinBM5
1828-4
from: 1828-4
CCCC(/C=C(C(O)C(/C=C/C(O)=O)C)\C)C—
61828-6zinCM6
1828-5
from: 1828-5
CCCC(/C=C(C(O)C(/C=C/CCC(O)=O)C)\C)C—
71828-7zinDM7
1828-6;Methylmalonyl-CoA
from: 1828-6
CCCC(/C=C(C(O)C(/C=C/CCC(O)C(C(O)=O)C)C)\C)C—
81828-8zinDM8
1828-7;Methylmalonyl-CoA
from: 1828-7
CCCC(/C=C(C(O)C(/C=C/CCC(O)C(C(O)C(C(O)=O)C)C)C)\C)C—
91828-9zinEM9
1828-8;Methylmalonyl-CoA
from: 1828-8
CCCC(/C=C(C(O)C(/C=C/CCC(O)C(C(O)C(C(O)C(C)C(O)=O)C)C)C)\C)C—
101828-10zinFM10
1828-9;Methylmalonyl-CoA
from: 1828-9
CCCC(/C=C(C(O)C(/C=C/CCC(O)C(C(O)C(C(O)C(C)C(O)C(C)C(O)=O)C)C)C)\C)C—
111828-11zinFM11
1828-10
from: 1828-10
CCCC(/C=C(C(O)C(/C=C/CCC(O)C(C(O)C(C(O)C(C)C(O)C(C)CCC(O)=O)C)C)C)\C)C—
121828-12zinGM12
1828-11;Methylmalonyl-CoA
from: 1828-11
CCCC(/C=C(C(O)C(/C=C/CCC(O)C(C(O)C(C(O)C(C)C(O)C(C)CCC(O)C(C(O)=O)C)C)C)C)\C)C—
131828-13zinH—
1828-12
from: 1828-12
CC(C(C(C(C(C(CC/C=C/C(C(/C(C)=C/C(CCC)C)O)C)O)C)O)C)O)C(O)C(C)CCC(C(C(O)=O)C)O—
141828zinJ?—
1828-13
from: 1828-13
CC(C(C(C(C(C(CC/C=C/C(C(/C(C)=C/C(CCC)C)O)C)O)C)O)C)O)C(OC(C(C(O)=O)C)CC1)C1C—
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