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BGC0001823Hybrid

Weishanmycin

Producing organism
Streptomyces sp. CB02120-2
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I);PKS (Unknown)
Total steps
9
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map31 genes · 76,440 bp

KSKSAKSKSKSKSAKSER20 kb76.4 kb visible · 76,440 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
AAdenylation (A)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
CyHeterocyclization (Cy)
DHtDehydratase (DHt)
ECHEnoyl-CoA hydratase
MTMethyltransferase
BELBeta-elim. lyase
LPGLPG synthase C
ACPSACP synthase

Pathway Graphsteps arranged in biosynthetic order

9 steps · 8 edges
Step 1M1
?
+Alanine
Step 2M2
wsmW
+Cysteine
Step 3M3
wsmG
Trans-AT
Step 4M4
wsmG;wsmR
Trans-AT
Step 5M5
wsmR
Trans-AT
Step 6M6
wsmR
Trans-AT
Step 7M7
wsmR, wsmJ
Trans-AT
Step 8M8
wsmR
Trans-AT
Step 9TE
wsmR, ?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions9 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11823-1?M1
Alanine
CC(N)C(O)=O—
21823-2wsmWM2
1823-1;Cysteine
from: 1823-1
C[C@@H](N)C1=NC(C(O)=O)=CS1—
31823-3wsmGM3
1823-2
from: 1823-2
CCC/C(C(O)=O)=C/C1=CSC([C@H](N)C)=N1{'transAT': ['wsmF', 'Malony…
41823-4wsmG;wsmRM4
1823-3
from: 1823-3
OC(/C=C/C(CCC)=C\C1=CSC([C@H](N)C)=N1)=O{'transAT': ['wsmJ', 'Malony…
51823-5wsmRM5
1823-4
from: 1823-4
C=C(/C=C/C(CCC)=C\C1=CSC([C@H](N)C)=N1)CC(O)=O{'transAT': ['wsmJ', 'Malony…
61823-6wsmRM6
1823-5
from: 1823-5
OC(/C(C)=C/CC(/C=C/C(CCC)=C\C1=CSC([C@H](N)C)=N1)=C)=O{'transAT': ['wsmJ', 'Malony…
71823-7wsmR, wsmJM7
1823-6
from: 1823-6
O=C(CC/C(C)=C/CC(/C=C/C(CCC)=C\C1=CSC([C@H](N)C)=N1)=C)O{'transAT': ['wsmJ', 'Malony…
81823-8wsmRM8
1823-7
from: 1823-7
C/C(CCC(SS)(CC(O)=O)CC(O)=O)=C\CC(/C=C/C(CCC)=C\C1=CSC([C@H](N)C)=N1)=C{'transAT': ['wsmJ', 'Malony…
91823wsmR, ?TE
1823-8
from: 1823-8
CCCC(/C=C/C(C[C@H]1S[C@](CC[C@@]1(O)C)(CC(O)=O)CC2=O)=C)=C/C3=CSC([C@H](N2)C)=N3—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture