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BGC0001819PKS

Venemycin

Producing organism
Streptomyces venezuelae
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
6
DOI
MIBiG entry
View on MIBiG ↗
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Venemycin
C11H8O5220.04 Da

Gene Cluster Map16 genes · 29,563 bp

ECHKSATTECALKSATECHECH5 kb29.6 kb visible · 29,563 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
ECHEnoyl-CoA hydratase
CALCoA-ligase (CAL)

Pathway Graphsteps arranged in biosynthetic order

6 steps · 5 edges
Step 1
vnz_RS02360, vnz_RS0236…
+Malonyl-CoA, Malonyl-CoA
Step 2
vnz_RS02375, vnz_RS02380
Step 3Load
vnz_RS02325
Step 4M1
vnz_RS02325
+Malonyl-CoA
Step 5M2
vnz_RS02320
+Malonyl-CoA
Step 6TE
vnz_RS02320
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions6 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11819-1vnz_RS02360, vnz_RS02365, vnz_RS02370, vnz_RS02310—
Malonyl-CoA;Malonyl-CoA;Malonyl-CoA;Malonyl-CoA
O=C(C(C1=CC(O)=CC(O)=C1)=O)O—
21819-2vnz_RS02375, vnz_RS02380—
1819-1
from: 1819-1
OC(C1=CC(O)=CC(O)=C1)=O—
31819-3vnz_RS02325Loading
1819-2
from: 1819-2
OC(C1=CC(O)=CC(O)=C1)=O—
41819-4vnz_RS02325M1
1819-3;Malonyl-CoA
from: 1819-3
O=C(C1=CC(O)=CC(O)=C1)CC(O)=O—
51819-5vnz_RS02320M2
1819-4;Malonyl-CoA
from: 1819-4
O=C(C1=CC(O)=CC(O)=C1)CC(CC(O)=O)=O—
61819vnz_RS02320TE
1819-5
from: 1819-5
OC1=CC(O)=CC(C2=CC(O)=CC(O2)=O)=C1—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture