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BGC0001818NRPS

Vazabitide A

Producing organism
Streptomyces sp. SANK 60404
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
8
DOI
MIBiG entry
View on MIBiG ↗
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vazabitide A
C12H21N3O4271.15 Da

Gene Cluster Map46 genes · 40,455 bp

CATEBELTEA10 kb40.5 kb visible · 40,455 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
BELBeta-elim. lyase

Pathway Graphsteps arranged in biosynthetic order

8 steps · 7 edges
Step 1
Start
+Glucose
Step 2
vzb22;vzb23
Step 3
vzb25
Step 4
vzb24
Step 5
vzb27, vzb28
Step 6
vzb29
Step 7
vzb26
Step 8
vzb7, vzb15, ?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions8 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11818-1Start—
Glucose
N[C@@H](CCC(O)=O)C(O)=O—
21818-2vzb22;vzb23—
1818-1
from: 1818-1
O=C(O)[C@H](CCC(O)=O)NO—
31818-3vzb25—
1818-2
from: 1818-2
O=C(O)[C@H](CCC(OP(O)(O)=O)=O)NO—
41818-4vzb24—
1818-3
from: 1818-3
O=C(O)[C@H](CCC([H])=O)NO—
51818-5vzb27, vzb28—
1818-4
from: 1818-4
O=C(O)[C@H](CC[C@@H](O)C(CO)=O)NO—
61818-6vzb29—
1818-5
from: 1818-5
O=C(O)[C@H](CC[C@@H](O)[C@@H](CO)N)NO—
71818-7vzb26—
1818-6
from: 1818-6
N[C@@H](CC[C@@H](O)[C@@H](CO)N)C(O)=O—
81818vzb7, vzb15, ?—
1818-7
from: 1818-7
OC1CC(C(NC([C@@H](N)C(C)C)=O)C(O)=O)N2C1C2—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture