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BGC0001814NRPS

Ulleungmycin

Producing organism
Streptomyces sp. KCB13F003
Taxonomy
BacteriaActinomycetotaActinomycetesKitasatosporalesStreptomycetaceaeStreptomyces
Biosynthetic class
NRPS (Type I)
Total steps
10
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map36 genes · 57,737 bp

ACAECAECACACAETauDAmT10 kb57.7 kb visible · 57,737 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
TEThioesterase (TE)
EEpimerization (E)
AmTAminotransferase I/II
AmTAminotransferase IV
TauDTauD oxygenase
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

10 steps · 9 edges
Step 1
Start
+Tryptophan
Step 2M1
(ulm26, ulm24);ulmA
Step 3M2
ulmA
+D-Valine
Step 4M3
ulmA
+(D-Homoleucine/D-…
Step 5M4
ulmA
+L-allo-Isoleucine
Step 6M5
ulmB
+L-Ornithine
Step 7M6
ulmB
+D-threo-β-OH-Aspa…
Step 8TE
ulm7
Step 9TE
ulm7
Step 10TE
ulm7
Starting stepIntermediateFinal productModuleLoadingTENo modulePKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions10 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11814-1Start
Tryptophan
O=C([C@H](CC1=CNC2=C1C=CC=C2)N)O
21814-2(ulm26, ulm24);ulmAM1
1814-1
from: 1814-1
O=C([C@H](CC1=CNC2=C1C=C(Cl)C=C2)N)O
31814-3ulmAM2
1814-2;D-Valine
from: 1814-2
O=C([C@H](CC1=CNC2=C1C=C(Cl)C=C2)N)N[C@H](C(C)C)C(N)=O
41814-4ulmAM3
1814-3;(D-Homoleucine/D-Leucine)
from: 1814-3
O=C([C@H](CC1=CNC2=C1C=C(Cl)C=C2)N)N[C@H](C(C)C)C(N[C@H]([R])C(O)=O)=O
51814-5ulmAM4
1814-4;L-allo-Isoleucine
from: 1814-4
O=C([C@H](CC1=CNC2=C1C=C(Cl)C=C2)N)N[C@H](C(C)C)C(N[C@H]([R])C(N[C@@H]([C@@H](CC)C)C(O)=O)=O)=O
61814-6ulmBM5
1814-5;L-Ornithine
from: 1814-5
O=C([C@H](CC1=CNC2=C1C=C(Cl)C=C2)N)N[C@H](C(C)C)C(N[C@H]([R])C(N[C@@H]([C@@H](CC)C)C(N[C@@H](CCCN)C(O)=O)=O)=O)=O
71814-7ulmBM6
1814-6;D-threo-β-OH-Asparagine
from: 1814-6
O=C([C@H](CC1=CNC2=C1C=C(Cl)C=C2)N)N[C@H](C(C)C)C(N[C@H]([R])C(N[C@@H]([C@@H](CC)C)C(N[C@@H](CCCN)C(N[C@H]([C@H](C(N)=O)O)C(O)=O)=O)=O)=O)=O
81814-8ulm7TE
1814-7
from: 1814-7
O=C([C@H](CC1=CNC2=C1C=C(Cl)C=C2)NC(C([C@H](C(N)=O)O)NC([C@H](CCCN)NC([C@H]([C@@H](CC)C)N3)=O)=O)=O)N[C@H](C(C)C)C(N[C@H]([R])C3=O)=O
91814(1)ulm7TE
1814-7
from: 1814-7
O=C([C@H](CC1=CNC2=C1C=C(Cl)C=C2)NC(C([C@H](C(N)=O)O)NC([C@H](CCCN)NC([C@H]([C@@H](CC)C)N3)=O)=O)=O)N[C@H](C(C)C)C(N[C@H](CCC(C)C)C3=O)=O
101814(2)ulm7TE
1814-7
from: 1814-7
O=C([C@H](CC1=CNC2=C1C=C(Cl)C=C2)NC(C([C@H](C(N)=O)O)NC([C@H](CCCN)NC([C@H]([C@@H](CC)C)N3)=O)=O)=O)N[C@H](C(C)C)C(N[C@H](CC(C)C)C3=O)=O
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture