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BGC0001813NRPS

Tyrobetaine

Producing organism
Streptomyces sp. NRRL WC-3703
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
NRPS (Type I)
Total steps
5
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map16 genes · 28,112 bp

AMTCACACAKSDHtTD5 kb28.1 kb visible · 28,112 bp total
Biosynthetic (core)
Biosynthetic (additional)
Transport
Unknown
Domains
KSKetosynthase (KS)
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
ACPAcyl carrier (ACP)
DHtDehydratase (DHt)
MTMethyltransferase
TDTerminal reductase

Pathway Graphsteps arranged in biosynthetic order

5 steps · 4 edges
Step 1
IF71_RS0139180
+L-Tyrosine
Step 2
IF71_RS0139180
+L-Tyrosine
Step 3
IF71_RS0139180
+Hydroxyleucine
Step 4
IF71_RS0139180;IF71_RS0…
+Alanine
Step 5
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions5 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11813-1IF71_RS0139180—
L-Tyrosine
OC(C([N+](C)(C)C)CC1=CC=C(O)C=C1)=O—
21813-2IF71_RS0139180—
1813-1;L-Tyrosine
from: 1813-1
OC([C@H](CC1=CC=C(O)C=C1)NC(C([N+](C)(C)C)CC2=CC=C(O)C=C2)=O)=O—
31813-3IF71_RS0139180—
1813-2;Hydroxyleucine
from: 1813-2
OC(C(C(C(C)C)O)NC([C@H](CC1=CC=C(O)C=C1)NC(C([N+](C)(C)C)CC2=CC=C(O)C=C2)=O)=O)=O—
41813-4IF71_RS0139180;IF71_RS0139190;IF71_RS1000000145670—
1813-3;Alanine
from: 1813-3
C[C@@H](C(O)=O)NC(C(C(C(C)C)O)NC([C@H](CC1=CC=C(O)C=C1)NC(C([N+](C)(C)C)CC2=CC=C(O)C=C2)=O)=O)=O—
51813?—
1813-4
from: 1813-4
C[C@@H](C(O)=O)NC(C(C(C(C)C)O)NC([C@H](CC1=CC=C(O)C=C1)NC(C([N+](C)(C)C)CC2=CC=C(O)C=C2)=O)=O)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture