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BGC0001812PKS

Tylactone

Producing organism
Micromonospora chalcea subsp. izumensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Micromonosporales›Micromonosporaceae›Micromonospora
Biosynthetic class
PKS (Unknown)
Total steps
9
DOI
MIBiG entry
View on MIBiG ↗
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tylactone
C23H38O5394.27 Da

Gene Cluster Map29 genes · 73,895 bp

KSKSKSKSKSKSKSKSER10 kb73.9 kb visible · 73,895 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Resistance
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
DHtDehydratase (DHt)
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

9 steps · 8 edges
Step 1Load
juvEI
+Methylmalonyl-CoA
Step 2M1
juvEI
+Methylmalonyl-CoA
Step 3M2
juvEI
+Methylmalonyl-CoA
Step 4M3
juvEII
+Malonyl-CoA
Step 5M4
juvEIII
+Methylmalonyl-CoA
Inactive: KR
Step 6M5
juvEIII
+Ethylmalonyl-CoA
Step 7M6
juvEIV
+Methylmalonyl-CoA
Step 8M7
juvEV
+Malonyl-CoA
Step 9TE
juvEV
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions9 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11812-1juvEILoading
Methylmalonyl-CoA
O=C(O)CC—
21812-2juvEIM1
1812-1;Methylmalonyl-CoA
from: 1812-1
O[C@@H]([C@@H](C)C(O)=O)CC—
31812-3juvEIM2
1812-2;Methylmalonyl-CoA
from: 1812-2
O[C@@H]([C@@H](C)/C=C(C)/C(O)=O)CC—
41812-4juvEIIM3
1812-3;Malonyl-CoA
from: 1812-3
O[C@@H]([C@@H](C)/C=C(C)/C=C/C(O)=O)CC—
51812-5juvEIIIM4
1812-4;Methylmalonyl-CoA
from: 1812-4
O[C@@H]([C@@H](C)/C=C(C)/C=C/C([C@H](C)C(O)=O)=O)CC{'Inactive': ['KR']}
61812-6juvEIIIM5
1812-5;Ethylmalonyl-CoA
from: 1812-5
O[C@@H]([C@@H](C)/C=C(C)/C=C/C([C@H](C)C[C@H](CC)C(O)=O)=O)CC—
71812-7juvEIVM6
1812-6;Methylmalonyl-CoA
from: 1812-6
O[C@@H]([C@@H](C)/C=C(C)/C=C/C([C@H](C)C[C@H](CC)[C@H](O)[C@@H](C)C(O)=O)=O)CC—
81812-8juvEVM7
1812-7;Malonyl-CoA
from: 1812-7
O[C@@H]([C@@H](C)/C=C(C)/C=C/C([C@H](C)C[C@H](CC)[C@H](O)[C@@H](C)[C@H](O)CC(O)=O)=O)CC—
91812juvEVTE
1812-8
from: 1812-8
O=C1O[C@H](CC)[C@@H](C)/C=C(C)/C=C/C([C@H](C)C[C@H](CC)[C@H](O)[C@@H](C)[C@H](O)C1)=O—
Click any row to view the chemical structure · Click a module badge (M1, TE…) to view domain architecture