NPdia

BGC0001801NRPS

Thiazostatin;Watasemycin A;Watasemycin B;2-hydroxyphenylthiazoline enantiopyochelin;Isopyochelin

Producing organism: Streptomyces venezuelae ATCC 10712
Taxonomy: Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class: NRPS (Type I)
Total steps: 11
DOI: 10.1039/C6SC03533G
MIBiG entry: View on MIBiG ↗

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C₁₆H₂₀N₂O₃S₂352.09 Da

Biosynthetic (core)

Biosynthetic (additional)

Regulatory

Transport

Unknown

Domains

Adenylation (A)

Peptidyl carrier (PCP)

Acyl carrier (ACP)

Thioesterase (TE)

Heterocyclization (Cy)

Methyltransferase

11 steps · 10 edges

Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions11 steps

Step	Product ID	Enzyme	Module	Substrate	Product SMILES	Notes
1	`1801-1`	Start	—		`OC(C1=CC(OC(C(O)=O)=C)[C@H](O)C=C1)=O`	—
2	`1801-2`	SVEN_0516	—	1801-1 from: 1801-1	`OC(C1=CC=CC=C1O)=O`	—
3	`1801-3`	SVEN_0510;SVEN_0512	—	1801-2 from: 1801-2	`OC(C1=CC=CC=C1O)=O`	—
4	`1801-4`	SVEN_0512	—	1801-3;Cysteine from: 1801-3	`OC([C@@]1([H])N=C(C2=C(O)C=CC=C2)SC1)=O`	—
5	`1801-5`	SVEN_0517	—	1801-4;Cysteine from: 1801-4	`[H][C@]1(C2=N[C@](C(O)=O)(C)CS2)N=C(C3=C(O)C=CC=C3)SC1`	—
6	`1801-6`	SVEN_0516	—	1801-5 from: 1801-5	`[H][C@]1(C2([H])SC[C@@](C(O)=O)(C)N2)N=C(C3=C(O)C=CC=C3)SC1`	—
7	`1801-7`	SVEN_0517	—	1801-6 from: 1801-6	`[H][C@]1(C2([H])SC[C@@](C(O)=O)(C)N2C)N=C(C3=C(O)C=CC=C3)SC1`	—
8	`1801(1)`	SVEN_0517	TE	1801-7 from: 1801-7	`[H][C@]1(C2([H])SC[C@@](C(O)=O)(C)N2C)N=C(C3=C(O)C=CC=C3)SC1`	—
9	`1801(2)`	SVEN_0515	—	1801(1)	`OC(C=CC=C1)=C1C2=N[C@]([C@]3([H])SC[C@](C)(C(O)=O)N3C)([H])[C@@](C)([H])S2`	—
10	`1801(3)`	SVEN_0515	—	1801(1)	`OC(C=CC=C1)=C1C2=N[C@@]([C@@]3([H])SC[C@](C)(C(O)=O)N3C)([H])[C@@](C)([H])S2`	—
11	`1801(4)`	SVEN_0517	TE	1801-6 from: 1801-6	`[H][C@]1(C2([H])SC[C@@](C(O)=O)(C)N2)N=C(C3=C(O)C=CC=C3)SC1`	—

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