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BGC0001792NRPS

Surugamide A;Surugamide D

Producing organism
Streptomyces albidoflavus
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces›Streptomyces albidoflavus group
Biosynthetic class
NRPS (Type I)
Total steps
14
DOI
MIBiG entry
View on MIBiG ↗
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C48H81N9O8911.62 Da

Gene Cluster Map21 genes · 82,464 bp

AAAAAAAAA20 kb82.5 kb visible · 82,464 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Unknown
Domains
CCondensation (C)
AAdenylation (A)
PCPPeptidyl carrier (PCP)
EEpimerization (E)
TgrTIGR01720

Pathway Graphsteps arranged in biosynthetic order

14 steps · 13 edges
Step 1M1
XNR_3449
+Valine/Isoleucine
Step 2M2
XNR_3449
+Alanine
Step 3M3
XNR_3449
+(Valine/Isoleucin…
Step 4M4
XNR_3449
+(Valine/Isoleucin…
Step 5M5
XNR_3449
+Lysine
Step 6M6
XNR_3446
+(Valine/Isoleucin…
Step 7M7
XNR_3446
+Phenylalanine
Step 8M8
XNR_3446
+Leucine
Step 9TE
XNR_3450
Step 10TE
XNR_3450
Step 11TE
XNR_3450
Step 12TE
XNR_3450
Step 13TE
XNR_3450
Step 14TE
XNR_3450
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions14 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11792-1XNR_3449M1
Valine/Isoleucine
N[C@H](C(O)=O)[C@H]([R1])C—
21792-2XNR_3449M2
1792-1;Alanine
from: 1792-1
N[C@H](C(N[C@H](C)C(O)=O)=O)[C@H]([R1])C—
31792-3XNR_3449M3
1792-2;(Valine/Isoleucine)
from: 1792-2
N[C@H](C(N[C@H](C)C(N[C@@H]([C@H]([R2])C)C(O)=O)=O)=O)[C@H]([R1])C—
41792-4XNR_3449M4
1792-3;(Valine/Isoleucine)
from: 1792-3
N[C@H](C(N[C@H](C)C(N[C@@H]([C@H]([R2])C)C(N[C@@H]([C@H](C)[R3])C(O)=O)=O)=O)=O)[C@H]([R1])C—
51792-5XNR_3449M5
1792-4;Lysine
from: 1792-4
N[C@H](C(N[C@H](C)C(N[C@@H]([C@H]([R2])C)C(N[C@@H]([C@H](C)[R3])C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)[C@H]([R1])C—
61792-6XNR_3446M6
1792-5;(Valine/Isoleucine)
from: 1792-5
N[C@H](C(N[C@H](C)C(N[C@@H]([C@H]([R2])C)C(N[C@@H]([C@H](C)[R3])C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)[R4])C(O)=O)=O)=O)=O)=O)=O)[C@H]([R1])C—
71792-7XNR_3446M7
1792-6;Phenylalanine
from: 1792-6
N[C@H](C(N[C@H](C)C(N[C@@H]([C@H]([R2])C)C(N[C@@H]([C@H](C)[R3])C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)[R4])C(N[C@H](CC1=CC=CC=C1)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H]([R1])C—
81792-8XNR_3446M8
1792-7;Leucine
from: 1792-7
N[C@H](C(N[C@H](C)C(N[C@@H]([C@H]([R2])C)C(N[C@@H]([C@H](C)[R3])C(N[C@@H](CCCCN)C(N[C@@H]([C@@H](C)[R4])C(N[C@H](CC1=CC=CC=C1)C(N[C@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([R1])C—
91792-9XNR_3450TE
1792-8
from: 1792-8
O=C([C@H](CCCCN)CC([C@@H]([C@H]([R3])C)NC([C@H]([C@@H](C)[R2])NC([C@@H](C)N1)=O)=O)=O)N[C@@H]([C@@H](C)[R4])C(N[C@H](CC2=CC=CC=C2)C(N[C@@H](C(N[C@@H]([C@@H](C)[R1])C1=O)=O)CC(C)C)=O)=O—
101792(1)XNR_3450TE
1792-8
from: 1792-8
O=C([C@H](CCCCN)CC([C@@H]([C@H](CC)C)NC([C@H]([C@@H](C)CC)NC([C@@H](C)N1)=O)=O)=O)N[C@@H]([C@@H](C)CC)C(N[C@H](CC2=CC=CC=C2)C(N[C@@H](C(N[C@@H]([C@@H](C)CC)C1=O)=O)CC(C)C)=O)=O—
111792(2)XNR_3450TE
1792-8
from: 1792-8
O=C([C@H](CCCCN)CC([C@@H](C(C)C)NC([C@H]([C@@H](C)CC)NC([C@@H](C)N1)=O)=O)=O)N[C@@H]([C@@H](C)CC)C(N[C@H](CC2=CC=CC=C2)C(N[C@@H](C(N[C@@H]([C@@H](C)CC)C1=O)=O)CC(C)C)=O)=O—
121792(3)XNR_3450TE
1792-8
from: 1792-8
O=C([C@H](CCCCN)CC([C@@H]([C@H](CC)C)NC([C@H]([C@@H](C)CC)NC([C@@H](C)N1)=O)=O)=O)N[C@@H](C(C)C)C(N[C@H](CC2=CC=CC=C2)C(N[C@@H](C(N[C@@H]([C@@H](C)CC)C1=O)=O)CC(C)C)=O)=O—
131792(4)XNR_3450TE
1792-8
from: 1792-8
O=C([C@H](CCCCN)CC([C@@H]([C@H](CC)C)NC([C@H](C(C)C)NC([C@@H](C)N1)=O)=O)=O)N[C@@H]([C@@H](C)CC)C(N[C@H](CC2=CC=CC=C2)C(N[C@@H](C(N[C@@H]([C@@H](C)CC)C1=O)=O)CC(C)C)=O)=O—
141792(5)XNR_3450TE
1792-8
from: 1792-8
O=C([C@H](CCCCN)CC([C@@H]([C@H](CC)C)NC([C@H]([C@@H](C)CC)NC([C@@H](C)N1)=O)=O)=O)N[C@@H]([C@@H](C)CC)C(N[C@H](CC2=CC=CC=C2)C(N[C@@H](C(N[C@@H](C(C)C)C1=O)=O)CC(C)C)=O)=O—
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