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BGC0001785PKS

Streptovaricin

Producing organism
Streptomyces spectabilis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
15
DOI
MIBiG entry
View on MIBiG ↗
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streptovaricin
C40H51NO14769.33 Da

Gene Cluster Map41 genes · 95,304 bp

20 kb95.3 kb visible · 95,304 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
CCondensation (C)
DnDocking N-term
DcDocking C-term
MTMethyltransferase
CALCoA-ligase (CAL)
AmTAminotransferase I/II

Pathway Graphsteps arranged in biosynthetic order

15 steps · 14 edges
Step 1Load
stvA
+AHBA
Step 2M1
stvA
+Methylmalonyl-CoA
Inactive: DH
Step 3M2
stvA
+Malonyl-CoA
Inactive: DH
Step 4M3
stvA
+Methylmalonyl-CoA
Inactive: KR
Step 5
stvP3?
Step 6M4
stvB
+Methylmalonyl-CoA
Step 7M5
stvB
+Methylmalonyl-CoA
Inactive: DH
Step 8M6
stvC
+Methylmalonyl-CoA
Inactive: DH
Step 9M7
stvC
+Methylmalonyl-CoA
Inactive: DH
Step 10M8
stvD
+Methylmalonyl-CoA
Inactive: DH
Step 11M9
stvE
+Malonyl-CoA
Step 12M10
stvE
+Methylmalonyl-CoA
Step 13
?
Step 14
?
Step 15
stvP1, stvP2?, stvP4, s…
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions15 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11785-1stvALoading
AHBA
NC1=CC(C(O)=O)=CC(O)=C1—
21785-2stvAM1
1785-1;Methylmalonyl-CoA
from: 1785-1
NC1=CC(C(O)C(C)C(O)=O)=CC(O)=C1{'Inactive': ['DH']}
31785-3stvAM2
1785-2;Malonyl-CoA
from: 1785-2
NC1=CC(C(O)C(C)C(CC(O)=O)=O)=CC(O)=C1{'Inactive': ['DH']}
41785-4stvAM3
1785-3;Methylmalonyl-CoA
from: 1785-3
NC1=CC(C(O)C(C)C(CC(C(C(O)=O)C)=O)=O)=CC(C)=C1{'Inactive': ['KR']}
51785-5stvP3?—
1785-4
from: 1785-4
NC(C(C(C(O)C(C)C(CC(C(C(O)=O)C)=O)=O)=C1)=O)=CC1=O—
61785-6stvBM4
1785-5;Methylmalonyl-CoA
from: 1785-5
NC(C(C1=C2C(O)C(C)C(O)=C1C(/C(C)=C/C(C)C(O)=O)=O)=O)=CC2=O—
71785-7stvBM5
1785-6;Methylmalonyl-CoA
from: 1785-6
NC(C(C1=C2C(O)C(C)C(O)=C1C(/C(C)=C/C(C)C(O)C(C)C(O)=O)=O)=O)=CC2=O{'Inactive': ['DH']}
81785-8stvCM6
1785-7;Methylmalonyl-CoA
from: 1785-7
NC(C(C1=C2C(O)C(C)C(O)=C1C(/C(C)=C/C(C)C(O)C(C)C(O)C(C)C(O)=O)=O)=O)=CC2=O{'Inactive': ['DH']}
91785-9stvCM7
1785-8;Methylmalonyl-CoA
from: 1785-8
NC(C(C1=C2C(O)C(C)C(O)=C1C(/C(C)=C/C(C)C(O)C(C)C(O)C(C)C(O)C(C)C(O)=O)=O)=O)=CC2=O{'Inactive': ['DH']}
101785-10stvDM8
1785-9;Methylmalonyl-CoA
from: 1785-9
NC(C(C1=C2C(O)C(C)C(O)=C1C(/C(C)=C/C(C)C(O)C(C)C(O)C(C)C(O)C(C)C(O)C(C)C(O)=O)=O)=O)=CC2=O{'Inactive': ['DH']}
111785-11stvEM9
1785-10;Malonyl-CoA
from: 1785-10
NC(C(C1=C2C(O)C(C)C(O)=C1C(/C(C)=C/C(C)C(O)C(C)C(O)C(C)C(O)C(C)C(O)C(C)/C=C/C(O)=O)=O)=O)=CC2=O—
121785-12stvEM10
1785-11;Methylmalonyl-CoA
from: 1785-11
NC(C(C1=C2C(O)C(C)C(O)=C1C(/C(C)=C/C(C)C(O)C(C)C(O)C(C)C(O)C(C)C(O)C(C)/C=C/C=C(C)/C(O)=O)=O)=O)=CC2=O—
131785-13?—
1785-12
from: 1785-12
CC1=C(NC(/C(C)=C/C=C\[C@@H](C)[C@@H]([C@@H](C)[C@H]2O)O)=O)C(C3=C(C1=O)C(C(/C(C)=C/[C@@H](C)[C@H]([C@H]([C@@H](O)[C@@H]2C)C)O)=O)=C(O)C(C)C3O)=O—
141785-14?—
1785-13
from: 1785-13
CC1=C(NC(/C(C)=C/C=C\[C@@H](C)[C@@H]([C@@H](C)[C@H]2O)O)=O)C(C3=C(C1=O)C(C(/C(C)=C/[C@@H](C)[C@H]([C@H]([C@@H](O)[C@@H]2C)C)O)=O)=C(O)C(C)=C3O)=O—
151785stvP1, stvP2?, stvP4, stvP5, ?—
1785-14
from: 1785-14
CC(C(NC(/C(C)=C/C=C\[C@@H](C)[C@@H]([C@@H](C)[C@H]1O)O)=O)=C2O)=C(OC(C)=O)C3=C2C(C(C)=C4OCOC(/C(C)=C/[C@](C)(O)[C@H]([C@H]([C@@H](O)[C@@H]1C(OC)=O)C)O)=C34)=O—
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