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BGC0001784PKS

Streptoseomycin

Producing organism
Streptomyces seoulensis
Taxonomy
Bacteria›Actinomycetota›Actinomycetes›Kitasatosporales›Streptomycetaceae›Streptomyces
Biosynthetic class
PKS (Unknown)
Total steps
18
DOI
MIBiG entry
View on MIBiG ↗

Gene Cluster Map41 genes · 95,952 bp

20 kb96.0 kb visible · 95,952 bp total
Biosynthetic (core)
Biosynthetic (additional)
Regulatory
Transport
Other
Unknown
Domains
KSKetosynthase (KS)
ATAcyltransferase (AT)
DHDehydratase (DH)
EREnoylreductase (ER)
KRKetoreductase (KR)
ACPAcyl carrier protein (ACP)
ACPAcyl carrier (ACP)
TEThioesterase (TE)
DnDocking N-term
DcDocking C-term
MTMethyltransferase
TauDTauD oxygenase

Pathway Graphsteps arranged in biosynthetic order

18 steps · 17 edges
Step 1Load
AWH12936.1
+Methylmalonyl-CoA
Step 13
Start
Step 14
Start
Step 2M1
AWH12936.1
+Methylmalonyl-CoA
Step 15
AWH12923.1, AWH12926.1
Step 3M2
AWH12936.1
+Methylmalonyl-CoA
Step 16
AWH12910.1
Step 4M3
AWH12936.1
+Malonyl-CoA
Step 17
AWH12927.1, ?
Step 5M4
AWH12937.1
+Malonyl-CoA
Step 6M5
AWH12937.1
+Malonyl-CoA
Step 7M6
AWH12937.1
+Malonyl-CoA
Step 8M7
AWH12938.1
+Malonyl-CoA
Step 9M8
AWH12938.1
+Malonyl-CoA
Step 10TE
AWH12938.1
Step 11
?
Step 12
?
Step 18
?
Starting stepIntermediateFinal product│ModuleLoadingTENo module│PKS stepNRPS stepTailoring/otherScroll to pan · Wheel to zoom

Biosynthetic Reactions18 steps

StepProduct IDEnzymeModuleSubstrateProduct SMILESNotes
11784-1AWH12936.1Loading
Methylmalonyl-CoA
CCC(O)=O—
21784-2AWH12936.1M1
1784-1;Methylmalonyl-CoA
from: 1784-1
CC[C@@H](O)C(C)C(O)=O—
31784-3AWH12936.1M2
1784-2;Methylmalonyl-CoA
from: 1784-2
CC[C@@H](O)C(C)/C=C(C(O)=O)\C—
41784-4AWH12936.1M3
1784-3;Malonyl-CoA
from: 1784-3
CC[C@@H](O)C(C)/C=C(/C=C/C(O)=O)C—
51784-5AWH12937.1M4
1784-4;Malonyl-CoA
from: 1784-4
CC[C@@H](O)C(C)/C=C(/C=C/[C@@H](O)CC(O)=O)C—
61784-6AWH12937.1M5
1784-5;Malonyl-CoA
from: 1784-5
CC[C@@H](O)C(C)/C=C(/C=C/[C@@H](O)C[C@@H](O)CC(O)=O)C—
71784-7AWH12937.1M6
1784-6;Malonyl-CoA
from: 1784-6
CC[C@@H](O)C(C)/C=C(/C=C/[C@@H](O)C[C@@H](O)C/C=C/C(O)=O)C—
81784-8AWH12938.1M7
1784-7;Malonyl-CoA
from: 1784-7
CC[C@@H](O)C(C)/C=C(/C=C/[C@@H](O)C[C@@H](O)C/C=C/C=C/C(O)=O)C—
91784-9AWH12938.1M8
1784-8;Malonyl-CoA
from: 1784-8
CC[C@@H](O)C(C)/C=C(/C=C/[C@@H](O)C[C@@H](O)C/C=C/C=C/C=C/C(O)=O)C—
101784-10AWH12938.1TE
1784-9
from: 1784-9
O=C1/C=C/C=C/C=C/C[C@@H](O)C[C@@H](O)/C=C\C(C)=C\[C@](C)([H])[C@](CC)([H])O1—
111784-11?—
1784-10
from: 1784-10
O=C1/C=C/[C@]2([H])[C@@]([C@]3([H])[C@H](O)C[C@H](O)C[C@]3([H])C=C2)([H])/C(C)=C/[C@](C)([H])[C@](CC)([H])O1—
121784-12?—
1784-11
from: 1784-11
O=C1[C@@H](OC)C[C@]2([H])[C@@]([C@]3([H])[C@H](O)C[C@H]4C[C@]3([H])C=C2)(O4)/C(C)=C/[C@](CO)([H])[C@]([C@H](O)CO)([H])O1—
131784-13Start—
O=C([R])C(C([O-])=O)CC[R*]—
141784-14Start—
O=C(C(CCC(O)=O)=O)O—
151784-15AWH12923.1, AWH12926.1—
1784-13;1784-14
from: 1784-13, 1784-14
O=C([R])C(C(CCC(O)=O)(O)C(O)=O)CC[R*]—
161784-16AWH12910.1—
1784-15
from: 1784-15
[R*]CCC(C(OC1=O)=O)C1(O)CCC(O)=O—
171784-17AWH12927.1, ?—
1784-16
from: 1784-16
[R*]CCC(C(NC1=O)=O)=C1CCC(O)=O—
181784?—
1784-12;1784-17
from: 1784-12, 1784-17
O=C1[C@@H](OC)C[C@]2([H])[C@@]([C@]3([H])[C@H](O)C[C@H]4C[C@]3([H])C=C2)(O4)/C(C)=C/[C@](CO5)([H])[C@]([C@H](O)CO/C=C/C(C(NC6=O)=O)=C6CCC5=O)([H])O1—
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